Abstract：
:Cholesterol levels in mammalian cells are controlled by an intricate mechanism in which the transcription factor SREBP plays a key role. Work in this issue (Radhakrishnan et al., 2008) employing direct measurement of endoplasmic reticulum cholesterol levels offers insights into the "switch" that controls this system with surprising precision.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Hampton RYdoi
10.1016/j.cmet.2008.11.006subject
Has Abstractpub_date
2008-12-01 00:00:00pages
451-3issue
6eissn
1550-4131issn
1932-7420pii
S1550-4131(08)00358-6journal_volume
8pub_type
评论,杂志文章相关文献
Cell Metabolism文献大全abstract：:Adipocyte mobilization of fatty acids (lipolysis) is instrumental for energy expenditure. Lipolysis displays both spontaneous (basal) and hormone-stimulated activity. It is unknown if lipolysis is important for future body weight gain and associated disturbed glucose metabolism, and this was presently investigated in ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2018.05.004
更新日期：2018-07-03 00:00:00
abstract：:Age-related loss of muscle mass and force (sarcopenia) contributes to disability and increased mortality. Ryanodine receptor 1 (RyR1) is the skeletal muscle sarcoplasmic reticulum calcium release channel required for muscle contraction. RyR1 from aged (24 months) rodents was oxidized, cysteine-nitrosylated, and deplet...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2011.05.014
更新日期：2011-08-03 00:00:00
abstract：:Components involved in vesicle trafficking processes such as secretion, endocytosis, and autophagy are gaining recognition as important regulators and effectors of target of rapamycin (TOR) signaling. A recent report by now implicates Pmr1, a secretory pathway Ca(2+)/Mn(2+) ATPase located in the Golgi apparatus, as a ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2006.12.008
更新日期：2007-01-01 00:00:00
abstract：:Studying ciliopathies, like the Bardet-Biedl syndrome (BBS), allow the identification of signaling pathways potentially involved in common diseases, sharing phenotypic features like obesity or type 2 diabetes. Given the close association between obesity and insulin resistance, obese BBS patients would be expected to b...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2012.08.005
更新日期：2012-09-05 00:00:00
abstract：:How circulating signals of hunger and satiety enter the brain to reach neurons that govern energy balance has long remained a matter of controversy and speculation. Balland et al. (2014) now elucidate molecular mechanisms by which a highly specialized hypothalamic glial cell regulates transport of leptin across the bl...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2014.01.008
更新日期：2014-02-04 00:00:00
abstract：:Zika virus is a pathogen that poses serious consequences, including congenital microcephaly. Although many viruses reprogram host cell metabolism, whether Zika virus alters cellular metabolism and the functional consequences of Zika-induced metabolic changes remain unknown. Here, we show that Zika virus infection diff...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2019.01.024
更新日期：2019-05-07 00:00:00
abstract：:As a preview of the upcoming Cell Symposium on Exercise Metabolism in Gothenburg, Sweden, May 21-23 (http://cell-symposia.com/exercisemetabolism-2017/), several of our speakers and other Cell Press exercise enthusiasts share a wide range of experiences from bench pressing goals to bench research insights. ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2017.04.024
更新日期：2017-05-02 00:00:00
abstract：:The importance of neuropeptides in the hypothalamus has been experimentally established. Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters glutamate and GABA are largely unknown. Synaptic vesicular transporters (VGLUTs for glutamate and VGAT for GABA) are required for ve...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2007.04.001
更新日期：2007-05-01 00:00:00
abstract：:Suppressor of cytokine signaling-3 (Socs-3) negatively regulates the action of various cytokines, as well as the metabolic hormones leptin and insulin. Mice with haploinsufficiency of Socs-3, or those with neuronal deletion of Socs-3, are lean and more leptin and insulin sensitive. To examine the role of Socs-3 within...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2006.06.010
更新日期：2006-08-01 00:00:00
abstract：:Feeding behavior is exquisitely regulated by homeostatic and hedonic neural substrates that integrate energy demand as well as the reinforcing and rewarding aspects of food. Understanding the net contribution of homeostatic and reward-driven feeding has become critical because of the ubiquitous source of energy-dense ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2015.07.011
更新日期：2015-10-06 00:00:00
abstract：:Nuclear receptors (NRs) are key regulators of gene expression and physiology. Nearly half of all human NRs lack endogenous ligands including estrogen-related receptor α (ERRα). ERRα has important roles in cancer, metabolism, and skeletal homeostasis. Affinity chromatography of tissue lipidomes with the ERRα ligand-bin...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2015.12.010
更新日期：2016-03-08 00:00:00
abstract：:Mitochondria undergo architectural/functional changes in response to metabolic inputs. How this process is regulated in physiological feeding/fasting states remains unclear. Here we show that mitochondrial dynamics (notably fission and mitophagy) and biogenesis are transcriptional targets of the circadian regulator Bm...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2015.08.006
更新日期：2015-10-06 00:00:00
abstract：:Incretin hormones exert pleiotropic metabolic actions beyond the pancreas. Although the heart expresses both incretin receptors, the cardiac biology of GIP receptor (GIPR) action remains incompletely understood. Here we show that GIPR agonism did not impair the response to cardiac ischemia. In contrast, genetic elimin...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2017.11.003
更新日期：2018-02-06 00:00:00
abstract：:AMPK is a kinase involved in cell energy homeostasis. In this issue of Cell Metabolism, Chopra and colleagues (2011) reveal a new function of AMPK in stimulating fat absorption. AMPK enhances the expression of the bile acid transporter, BSEP, by activating the coactivator SRC-2, thus promoting bile acid secretion. ...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2010.12.009
更新日期：2011-01-05 00:00:00
abstract：:Peroxisome proliferator-activated receptor gamma coactivator-1 beta (PGC-1beta) is known to be a transcriptional coactivator for SREBP-1, the master regulator of hepatic lipogenesis. Here, we evaluated the role of PGC-1beta in the pathogenesis of fructose-induced insulin resistance by using an antisense oligonucletoid...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2009.01.011
更新日期：2009-03-01 00:00:00
abstract：:Cancer cells that leave their natural environment during metastatic spread must adapt to numerous stresses to survive. In this issue, Labuschagne et al. (2019) highlight one adaptive mechanism to overcome these stresses that involves cell clustering, which induces a hypoxic environment and metabolic rewiring to buffer...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2019.09.008
更新日期：2019-10-01 00:00:00
abstract：:Embryonic stem cells (ESCs) manifest a unique metabolism that is intimately linked to their pluripotent state. In this issue, Moussaieff et al. (2015) find that ESCs utilize glycolysis to fuel high rates of cytosolic acetyl-CoA synthesis to maintain the histone acetylation required for pluripotency. ...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2015.02.011
更新日期：2015-03-03 00:00:00
abstract：:Intense noise exposure causes hearing loss by inducing degeneration of spiral ganglia neurites that innervate cochlear hair cells. Nicotinamide adenine dinucleotide (NAD(+)) exhibits axon-protective effects in cultured neurons; however, its ability to block degeneration in vivo has been difficult to establish due to i...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2014.11.003
更新日期：2014-12-02 00:00:00
abstract：:Metabolic imaging using hyperpolarized magnetic resonance can increase the sensitivity of MRI, though its ability to inform on relevant changes to biochemistry in humans remains unclear. In this work, we image pyruvate metabolism in patients, assessing the reproducibility of delivery and conversion in the setting of p...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2019.08.024
更新日期：2020-01-07 00:00:00
abstract：:Mitochondrial dysfunction is associated with skeletal muscle pathology, including cachexia, sarcopenia, and the muscular dystrophies. ATP citrate lyase (ACL) is a cytosolic enzyme that catalyzes mitochondria-derived citrate into oxaloacetate and acetyl-CoA. Here we report that activation of ACL in skeletal muscle resu...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2015.05.006
更新日期：2015-06-02 00:00:00
abstract：:Over the past years, plenty of evidence has emerged illustrating how metabolism supports many aspects of cellular function and how metabolic reprogramming can drive cell differentiation and fate. Here, we present a method to assess the metabolic configuration of single cells within their native tissue microenvironment...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2017.08.014
更新日期：2017-11-07 00:00:00
abstract：:Insulin rapidly suppresses hepatic glucose production and slowly decreases expression of genes encoding gluconeogenic proteins. In this study, we show that an immediate effect of insulin is to redirect newly synthesized glucose-6-phosphate to glycogen without changing the rate of gluconeogenesis. This process requires...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2013.06.001
更新日期：2013-07-02 00:00:00
abstract：:Adipose tissue plays an important role in storing excess nutrients and preventing ectopic lipid accumulation in other organs. Obesity leads to excess lipid storage in adipocytes, resulting in the generation of stress signals and the derangement of metabolic functions. SIRT1 is an important regulatory sensor of nutrien...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2012.07.003
更新日期：2012-08-08 00:00:00
abstract：:Metformin is the first-line therapy for type 2 diabetes, but there are large inter-individual variations in responses to this drug. Its mechanism of action is not fully understood, but activation of AMP-activated protein kinase (AMPK) and changes in the gut microbiota appear to be important. The inhibitory role of mic...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2020.07.012
更新日期：2020-10-06 00:00:00
abstract：:Nonalcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in Western societies, affecting one in four adults in the USA, and is strongly associated with hepatic insulin resistance, a major risk factor in the pathogenesis of type 2 diabetes. Although the cellular mechanisms underlying this...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2012.03.005
更新日期：2012-05-02 00:00:00
abstract：:Microglia play a crucial role in immune responses, including inflammation. Diet-induced obesity (DIO) triggers microglia activation and hypothalamic inflammation as early as 3 days after high-fat diet (HFD) exposure, before changes in body weight occur. The intracellular mechanism(s) responsible for HFD-induced microg...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2019.08.010
更新日期：2019-11-05 00:00:00
abstract：:Mutations of mtDNA cause mitochondrial diseases and are implicated in age-associated diseases and aging. Pathogenic mtDNA mutations are often present in a fraction of all mtDNA copies, and it has been widely debated whether the proportion of mutant genomes or the absolute number of wild-type molecules determines if ox...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2017.07.003
更新日期：2017-08-01 00:00:00
abstract：:Dietary restriction (DR) was shown to impact on tumor growth with very variable effects depending on the cancer type. However, how DR limits cancer progression remains largely unknown. Here, we demonstrate that feeding mice a low-protein (Low PROT) isocaloric diet but not a low-carbohydrate (Low CHO) diet reduced tumo...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2018.02.009
更新日期：2018-04-03 00:00:00
abstract：:Food intake and activity-induced thermogenesis are important components of energy balance regulation. The molecular mechanism underlying the coordination of food intake with locomotory behavior to maintain energy homeostasis is unclear. We report that the brain-specific homeobox transcription factor Bsx is required fo...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2007.05.007
更新日期：2007-06-01 00:00:00
abstract：:Skin aging is of considerable interest from various perspectives, ranging from aesthetics to cancer development. Zhang et al. (2019) elucidate an immunological consequence of aging in the adipose layer of skin. Age-dependent increases in TGF-β signaling impair fibroblast adipogenic potential that results in impaired a...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2019.02.006
更新日期：2019-03-05 00:00:00
