Abstract：
:Feeding behavior is exquisitely regulated by homeostatic and hedonic neural substrates that integrate energy demand as well as the reinforcing and rewarding aspects of food. Understanding the net contribution of homeostatic and reward-driven feeding has become critical because of the ubiquitous source of energy-dense foods and the consequent obesity epidemic. Hypothalamic agouti-related peptide-secreting neurons (AgRP neurons) provide the primary orexigenic drive of homeostatic feeding. Using models of neuronal inhibition or ablation, we demonstrate that the feeding response to a fast ghrelin or serotonin receptor agonist relies on AgRP neurons. However, when palatable food is provided, AgRP neurons are dispensable for an appropriate feeding response. In addition, AgRP-ablated mice present exacerbated stress-induced anorexia and palatable food intake--a hallmark of comfort feeding. These results suggest that, when AgRP neuron activity is impaired, neural circuits sensitive to emotion and stress are engaged and modulated by food palatability and dopamine signaling.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Denis RG,Joly-Amado A,Webber E,Langlet F,Schaeffer M,Padilla SL,Cansell C,Dehouck B,Castel J,Delbès AS,Martinez S,Lacombe A,Rouch C,Kassis N,Fehrentz JA,Martinez J,Verdié P,Hnasko TS,Palmiter RD,Krashes MJ,Güler Adoi
10.1016/j.cmet.2015.07.011subject
Has Abstractpub_date
2015-10-06 00:00:00pages
646-57issue
4eissn
1550-4131issn
1932-7420pii
S1550-4131(15)00340-Xjournal_volume
22pub_type
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