Abstract：
:The importance of neuropeptides in the hypothalamus has been experimentally established. Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters glutamate and GABA are largely unknown. Synaptic vesicular transporters (VGLUTs for glutamate and VGAT for GABA) are required for vesicular uptake and, consequently, synaptic release of neurotransmitters. Ventromedial hypothalamic (VMH) neurons are predominantly glutamatergic and express VGLUT2. To evaluate the role of glutamate release from VMH neurons, we generated mice lacking VGLUT2 selectively in SF1 neurons (a major subset of VMH neurons). These mice have hypoglycemia during fasting secondary to impaired fasting-induced increases in the glucose-raising pancreatic hormone glucagon and impaired induction in liver of mRNAs encoding PGC-1alpha and the gluconeogenic enzymes PEPCK and G6Pase. Similarly, these mice have defective counterregulatory responses to insulin-induced hypoglycemia and 2-deoxyglucose (an antimetabolite). Thus, glutamate release from VMH neurons is an important component of the neurocircuitry that functions to prevent hypoglycemia.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Tong Q,Ye C,McCrimmon RJ,Dhillon H,Choi B,Kramer MD,Yu J,Yang Z,Christiansen LM,Lee CE,Choi CS,Zigman JM,Shulman GI,Sherwin RS,Elmquist JK,Lowell BBdoi
10.1016/j.cmet.2007.04.001subject
Has Abstractpub_date
2007-05-01 00:00:00pages
383-93issue
5eissn
1550-4131issn
1932-7420pii
S1550-4131(07)00096-4journal_volume
5pub_type
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