Abstract：
:Impaired insulin secretion contributes to the pathogenesis of type 2 diabetes mellitus (T2DM). Treatment with the incretin hormone glucagon-like peptide-1 (GLP-1) potentiates insulin secretion and improves metabolic control in humans with T2DM. GLP-1 receptor-mediated signaling leading to insulin secretion occurs via cyclic AMP stimulated protein kinase A (PKA)- as well as guanine nucleotide exchange factor-mediated pathways. However, how these two pathways integrate and coordinate insulin secretion remains poorly understood. Here we show that these incretin-stimulated pathways converge at the level of snapin, and that PKA-dependent phosphorylation of snapin increases interaction among insulin secretory vesicle-associated proteins, thereby potentiating glucose-stimulated insulin secretion (GSIS). In diabetic islets with impaired GSIS, snapin phosphorylation is reduced, and expression of a snapin mutant, which mimics site-specific phosphorylation, restores GSIS. Thus, snapin is a critical node in GSIS regulation and provides a potential therapeutic target to improve β cell function in T2DM.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Song WJ,Seshadri M,Ashraf U,Mdluli T,Mondal P,Keil M,Azevedo M,Kirschner LS,Stratakis CA,Hussain MAdoi
10.1016/j.cmet.2011.02.002subject
Has Abstractpub_date
2011-03-02 00:00:00pages
308-19issue
3eissn
1550-4131issn
1932-7420pii
S1550-4131(11)00046-5journal_volume
13pub_type
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