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Osteoclasts pump iron.

Abstract：

:Osteoclasts are the primary cells that resorb bone; they require high energy levels to degrade bone matrix, releasing minerals to maintain calcium homeostasis. Recent work on osteoclast differentiation and activity highlights an important role for mitochondrial biogenesis and explores the role of iron transferrin in generating a positive osteoclastogenic feedback loop.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Roodman GD

doi

10.1016/j.cmet.2009.04.005

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

405-6

issue

5

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(09)00096-5

journal_volume

9

pub_type

杂志文章

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