Abstract：
:Aerobic glycolysis (the Warburg effect) is a core hallmark of cancer, but the molecular mechanisms underlying it remain unclear. Here, we identify an unexpected central role for mTORC2 in cancer metabolic reprogramming where it controls glycolytic metabolism by ultimately regulating the cellular level of c-Myc. We show that mTORC2 promotes inactivating phosphorylation of class IIa histone deacetylases, which leads to the acetylation of FoxO1 and FoxO3, and this in turn releases c-Myc from a suppressive miR-34c-dependent network. These central features of activated mTORC2 signaling, acetylated FoxO, and c-Myc levels are highly intercorrelated in clinical samples and with shorter survival of GBM patients. These results identify a specific, Akt-independent role for mTORC2 in regulating glycolytic metabolism in cancer.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Masui K,Tanaka K,Akhavan D,Babic I,Gini B,Matsutani T,Iwanami A,Liu F,Villa GR,Gu Y,Campos C,Zhu S,Yang H,Yong WH,Cloughesy TF,Mellinghoff IK,Cavenee WK,Shaw RJ,Mischel PSdoi
10.1016/j.cmet.2013.09.013subject
Has Abstractpub_date
2013-11-05 00:00:00pages
726-39issue
5eissn
1550-4131issn
1932-7420pii
S1550-4131(13)00382-3journal_volume
18pub_type
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