Abstract:
:What are the pathways that underlie the coordinated responses of an organism to well-fed and food-deprived states? A report in this issue of Cell Metabolism suggests that starvation functions via a muscarinic acetylcholine receptor to activate MAP kinase signaling in the pharyngeal muscle of C. elegans (You et al., 2006).
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Ashrafi Kdoi
10.1016/j.cmet.2006.03.002keywords:
subject
Has Abstractpub_date
2006-04-01 00:00:00pages
235-6issue
4eissn
1550-4131issn
1932-7420pii
S1550-4131(06)00095-7journal_volume
3pub_type
评论,杂志文章相关文献
Cell Metabolism文献大全abstract::The symbiotic gut microbiota modulate health and disease of the host through a series of transgenomic metabolic and immune regulatory axes. We explore connections between microbiome composition and function related to individual metabolic phenotypes and consider these interactions as possible targets for developing ne...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2012.10.007
更新日期:2012-11-07 00:00:00
abstract::The essential role of the brain in maintaining energy homeostasis has motivated the drive to define the neural circuitry that integrates external and internal stimuli to enact appropriate and consequential metabolic and behavioral responses. The hypothalamus has received significant attention in this regard given its ...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2015.09.026
更新日期:2015-12-01 00:00:00
abstract::The circadian clock is a ubiquitous timekeeping system that organizes the behavior and physiology of organisms over the day and night. Current models rely on transcriptional networks that coordinate circadian gene expression of thousands of transcripts. However, recent studies have uncovered phylogenetically conserved...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2016.07.024
更新日期:2016-09-13 00:00:00
abstract::Peroxisome proliferator-activated receptor δ (PPARδ) is a critical regulator of energy metabolism in the heart. Here, we propose a mechanism that integrates two deleterious characteristics of heart failure, hypoxia and a metabolic shift toward glycolysis, involving the microRNA cluster miR-199a∼214 and PPARδ. We demon...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2013.08.009
更新日期:2013-09-03 00:00:00
abstract::Intestinal sugar sensing has an appetite-stimulating action that enhances preferences for sweets. Han et al. (2016) report that duodenal-jejunal bypass surgery reduces sweet appetite by reducing sugar-induced dopamine release in the dorsal striatum. ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2015.12.013
更新日期:2016-01-12 00:00:00
abstract::Long non-coding RNAs (lncRNAs) constitute a significant portion of mammalian genome, yet the physiological importance of lncRNAs is largely unknown. Here, we identify a liver-enriched lncRNA in mouse that we term liver-specific triglyceride regulator (lncLSTR). Mice with a liver-specific depletion of lncLSTR exhibit a...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.02.004
更新日期:2015-03-03 00:00:00
abstract::The discovery that their neonatal diabetes is caused by gain-of-function mutations in the K(ATP) channel has enabled many patients to switch from insulin to oral sulphonylurea drugs. Here, I review molecular, physiological, and clinical features of this change in therapy. ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2010.02.004
更新日期:2010-03-03 00:00:00
abstract::Obesity and atherosclerosis-related diseases account for over one-third of deaths in the western world. Controlling these conditions remains a major challenge due to an incomplete understanding of the molecular pathways involved. Here, we show that Wip1 phosphatase, a known negative regulator of Atm-dependent signalin...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2012.06.003
更新日期:2012-07-03 00:00:00
abstract::In flies, ecdysone integrates growth with developmental transitions by antagonizing insulin signaling, which links growth with nutritional status. Work in Developmental Cell (Delanoue et. al, 2010) finds that ecdysone represses the transcription factor Myc in the larval fat body to inhibit systemic growth, revealing a...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2010.06.003
更新日期:2010-07-07 00:00:00
abstract::Circulating levels of insulin and glucagon reflect the nutritional state of animals and elicit regulatory responses in the liver that maintain glucose and lipid homeostasis. The transcription factor Foxa2 activates lipid metabolism and ketogenesis during fasting and is inhibited via insulin-PI3K-Akt signaling-mediated...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2013.01.014
更新日期:2013-03-05 00:00:00
abstract::Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lip...
journal_title:Cell metabolism
pub_type: 信件
doi:10.1016/j.cmet.2019.05.014
更新日期:2019-07-02 00:00:00
abstract::Nicotinamide phosphoribosyltransferase (NAMPT), the key NAD(+) biosynthetic enzyme, has two different forms, intra- and extracellular (iNAMPT and eNAMPT), in mammals. However, the significance of eNAMPT secretion remains unclear. Here we demonstrate that deacetylation of iNAMPT by the mammalian NAD(+)-dependent deacet...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.04.002
更新日期:2015-05-05 00:00:00
abstract::The brain is the most cholesterol-rich organ in the body, most of which comes from in situ synthesis. Here we demonstrate that in insulin-deficient diabetic mice, there is a reduction in expression of the major transcriptional regulator of cholesterol metabolism, SREBP-2, and its downstream genes in the hypothalamus a...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2010.11.006
更新日期:2010-12-01 00:00:00
abstract::Incretin hormones exert pleiotropic metabolic actions beyond the pancreas. Although the heart expresses both incretin receptors, the cardiac biology of GIP receptor (GIPR) action remains incompletely understood. Here we show that GIPR agonism did not impair the response to cardiac ischemia. In contrast, genetic elimin...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2017.11.003
更新日期:2018-02-06 00:00:00
abstract::Iron overload is a risk factor for diabetes. The link between iron and diabetes was first recognized in pathologic conditions-hereditary hemochromatosis and thalassemia-but high levels of dietary iron also impart diabetes risk. Iron plays a direct and causal role in diabetes pathogenesis mediated both by β cell failur...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2013.02.007
更新日期:2013-03-05 00:00:00
abstract::Autophagy is a catabolic process that ensures homeostatic cell clearance and is deregulated in a growing number of myopathological conditions. Although FoxO3 was shown to promote the expression of autophagy-related genes in skeletal muscle, the mechanisms triggering autophagy are unclear. We show that TSC1-deficient m...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2013.03.015
更新日期:2013-05-07 00:00:00
abstract::The polarization of adipose tissue-resident macrophages toward the alternatively activated, anti-inflammatory M2 phenotype is believed to improve insulin sensitivity. However, the mechanisms controlling tissue macrophage activation remain unclear. Here we show that adipocytes are a source of Th2 cytokines, including I...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.04.002
更新日期:2008-06-01 00:00:00
abstract::Mitochondrial fatty acid oxidation provides an important energy source for cellular metabolism, and decreased mitochondrial fatty acid oxidation has been implicated in the pathogenesis of type 2 diabetes. Paradoxically, mice with an inherited deficiency of the mitochondrial fatty acid oxidation enzyme, very long-chain...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2010.03.012
更新日期:2010-05-05 00:00:00
abstract::In type 2 diabetes, pancreatic beta cells fail to secrete sufficient insulin to overcome peripheral insulin resistance. Intracellular lipid accumulation contributes to beta cell failure through poorly defined mechanisms. Here we report a role for the lipid-regulated protein kinase C isoform PKCepsilon in beta cell dys...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2007.08.012
更新日期:2007-10-01 00:00:00
abstract::Virus infections trigger metabolic changes in host cells that support the bioenergetic and biosynthetic demands of viral replication. Although recent studies have characterized virus-induced changes in host cell metabolism (Munger et al., 2008; Terry et al., 2012), the molecular mechanisms by which viruses reprogram c...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2014.03.009
更新日期:2014-04-01 00:00:00
abstract::Precise control of the thyroid hormone (T3)-dependent transcriptional program is required by multiple cell systems, including muscle stem cells. Deciphering how this is achieved and how the T3 signal is controlled in stem cell niches is essentially unknown. We report that in response to proliferative stimuli such as a...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2014.10.009
更新日期:2014-12-02 00:00:00
abstract::GCN2 is a sensor of amino acid deprivation that triggers a repression of global protein synthesis while simultaneously inducing translation of specific proteins. In this issue of Cell Metabolism, Guo and Cavener (2007) present a much broader role for GCN2 in controlling lipid homeostasis in response to amino acid depr...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2007.01.010
更新日期:2007-02-01 00:00:00
abstract::Pancreatic islet beta cell mass expands in response to certain physiological conditions such as pregnancy and obesity, but the signaling pathways involved are not well understood. Possible insights come from a newly described regulatory circuit through which obesity-enhanced kinase signaling in the liver triggers expa...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.12.009
更新日期:2009-01-07 00:00:00
abstract::Feeding behavior is exquisitely regulated by homeostatic and hedonic neural substrates that integrate energy demand as well as the reinforcing and rewarding aspects of food. Understanding the net contribution of homeostatic and reward-driven feeding has become critical because of the ubiquitous source of energy-dense ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.07.011
更新日期:2015-10-06 00:00:00
abstract::Cholesterol levels in mammalian cells are controlled by an intricate mechanism in which the transcription factor SREBP plays a key role. Work in this issue (Radhakrishnan et al., 2008) employing direct measurement of endoplasmic reticulum cholesterol levels offers insights into the "switch" that controls this system w...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2008.11.006
更新日期:2008-12-01 00:00:00
abstract::Impaired insulin secretion contributes to the pathogenesis of type 2 diabetes mellitus (T2DM). Treatment with the incretin hormone glucagon-like peptide-1 (GLP-1) potentiates insulin secretion and improves metabolic control in humans with T2DM. GLP-1 receptor-mediated signaling leading to insulin secretion occurs via ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2011.02.002
更新日期:2011-03-02 00:00:00
abstract::The ability of hormones such as insulin, leptin, and cholecystokinin to alter food intake is influenced by intricate interactions between homeostatic and non-homeostatic factors. Consequently, when administered exogenously, the likelihood of these hormones influencing food intake is probabilistic, leading to difficult...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.08.017
更新日期:2015-09-01 00:00:00
abstract::Cellular metabolite balance and mitochondrial function are under circadian control, but the pathways connecting the molecular clock to these functions are unclear. Peroxisome proliferator-activated receptor delta (PPARδ) enables preferential utilization of lipids as fuel during exercise and is a major driver of exerci...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2017.06.002
更新日期:2017-07-05 00:00:00
abstract::Microglia play a crucial role in immune responses, including inflammation. Diet-induced obesity (DIO) triggers microglia activation and hypothalamic inflammation as early as 3 days after high-fat diet (HFD) exposure, before changes in body weight occur. The intracellular mechanism(s) responsible for HFD-induced microg...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2019.08.010
更新日期:2019-11-05 00:00:00
abstract::In animal models, the physiological systems involved in metabolic homeostasis exhibit a sex difference. Investigators often use male rodents because they show metabolic disease better than females. Thus, females are not used precisely because of an acknowledged sex difference that represents an opportunity to understa...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2017.04.033
更新日期:2017-06-06 00:00:00