Abstract：
:Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here, we investigate the effect of alpha-ketoglutarate (delivered in the form of a calcium salt, CaAKG) on healthspan and lifespan in C57BL/6 mice. To probe the relationship between healthspan and lifespan extension in mammals, we performed a series of longitudinal, clinically relevant measurements. We find that CaAKG promotes a longer, healthier life associated with a decrease in levels of systemic inflammatory cytokines. We propose that induction of IL-10 by dietary AKG suppresses chronic inflammation, leading to health benefits. By simultaneously reducing frailty and enhancing longevity, AKG, at least in the murine model, results in a compression of morbidity.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Asadi Shahmirzadi A,Edgar D,Liao CY,Hsu YM,Lucanic M,Asadi Shahmirzadi A,Wiley CD,Gan G,Kim DE,Kasler HG,Kuehnemann C,Kaplowitz B,Bhaumik D,Riley RR,Kennedy BK,Lithgow GJdoi
10.1016/j.cmet.2020.08.004subject
Has Abstractpub_date
2020-09-01 00:00:00pages
447-456.e6issue
3eissn
1550-4131issn
1932-7420pii
S1550-4131(20)30417-4journal_volume
32pub_type
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