Abstract:
:The delivery of blood-borne molecules conveying metabolic information to neural networks that regulate energy homeostasis is restricted by brain barriers. The fenestrated endothelium of median eminence microvessels and tight junctions between tanycytes together compose one of these. Here, we show that the decrease in blood glucose levels during fasting alters the structural organization of this blood-hypothalamus barrier, resulting in the improved access of metabolic substrates to the arcuate nucleus. These changes are mimicked by 2-deoxyglucose-induced glucoprivation and reversed by raising blood glucose levels after fasting. Furthermore, we show that VEGF-A expression in tanycytes modulates these barrier properties. The neutralization of VEGF signaling blocks fasting-induced barrier remodeling and significantly impairs the physiological response to refeeding. These results implicate glucose in the control of blood-hypothalamus exchanges through a VEGF-dependent mechanism and demonstrate a hitherto unappreciated role for tanycytes and the permeable microvessels associated with them in the adaptive metabolic response to fasting.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Langlet F,Levin BE,Luquet S,Mazzone M,Messina A,Dunn-Meynell AA,Balland E,Lacombe A,Mazur D,Carmeliet P,Bouret SG,Prevot V,Dehouck Bdoi
10.1016/j.cmet.2013.03.004subject
Has Abstractpub_date
2013-04-02 00:00:00pages
607-17issue
4eissn
1550-4131issn
1932-7420pii
S1550-4131(13)00107-1journal_volume
17pub_type
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