Moving beyond GWAS and eQTL Analysis to Validated Hits in Chronic Kidney Disease.

Abstract:

:Genome-wide association studies (GWAS) have identified multiple chronic kidney disease (CKD)-associated single-nucleotide polymorphisms (SNPs) mainly localized to non-coding genomic regions. To understand which genes and which cell types are affected by these genetic variants, compartment-specific transcriptome, genome, and epigenome data were analyzed in an integrative manner in a recent study by Qiu et al. (Qiu et al., 2018).

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Müller-Deile J,Jobst-Schwan T,Schiffer M

doi

10.1016/j.cmet.2018.12.009

subject

Has Abstract

pub_date

2019-01-08 00:00:00

pages

9-10

issue

1

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(18)30746-0

journal_volume

29

pub_type

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