Abstract：
:Nuclear receptor signaling plays an important role in energy metabolism. In this study we demonstrate that the nuclear receptor corepressor RIP140 is a key regulator of metabolism in skeletal muscle. RIP140 is expressed in a fiber type-specific manner, and manipulation of its levels in null, heterozygous, and transgenic mice demonstrate that low levels promote while increased expression suppresses the formation of oxidative fibers. Expression profiling reveals global changes in the expression of genes implicated in both myofiber phenotype and metabolic functions. Genes involved in fatty-acid oxidation, oxidative phosphorylation, and mitochondrial biogenesis are upregulated in the absence of RIP140. Analysis of cultured myofibers demonstrates that the changes in expression are intrinsic to muscle cells and that nuclear receptor-regulated genes are direct targets for repression by RIP140. Therefore RIP140 is an important signaling factor in the regulation of skeletal muscle function and physiology.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Seth A,Steel JH,Nichol D,Pocock V,Kumaran MK,Fritah A,Mobberley M,Ryder TA,Rowlerson A,Scott J,Poutanen M,White R,Parker Mdoi
10.1016/j.cmet.2007.08.004subject
Has Abstractpub_date
2007-09-01 00:00:00pages
236-45issue
3eissn
1550-4131issn
1932-7420pii
S1550-4131(07)00226-4journal_volume
6pub_type
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