Abstract：
:Peroxisome proliferator-activated receptor δ (PPARδ) is a critical regulator of energy metabolism in the heart. Here, we propose a mechanism that integrates two deleterious characteristics of heart failure, hypoxia and a metabolic shift toward glycolysis, involving the microRNA cluster miR-199a∼214 and PPARδ. We demonstrate that under hemodynamic stress, cardiac hypoxia activates DNM3os, a noncoding transcript that harbors the microRNA cluster miR-199a∼214, which shares PPARδ as common target. To address the significance of miR-199a∼214 induction and concomitant PPARδ repression, we performed antagomir-based silencing of both microRNAs and subjected mice to biomechanical stress to induce heart failure. Remarkably, antagomir-treated animals displayed improved cardiac function and restored mitochondrial fatty acid oxidation. Taken together, our data suggest a mechanism whereby miR-199a∼214 actively represses cardiac PPARδ expression, facilitating a metabolic shift from predominant reliance on fatty acid utilization in the healthy myocardium toward increased reliance on glucose metabolism at the onset of heart failure.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
el Azzouzi H,Leptidis S,Dirkx E,Hoeks J,van Bree B,Brand K,McClellan EA,Poels E,Sluimer JC,van den Hoogenhof MM,Armand AS,Yin X,Langley S,Bourajjaj M,Olieslagers S,Krishnan J,Vooijs M,Kurihara H,Stubbs A,Pinto YM,doi
10.1016/j.cmet.2013.08.009subject
Has Abstractpub_date
2013-09-03 00:00:00pages
341-54issue
3eissn
1550-4131issn
1932-7420pii
S1550-4131(13)00335-5journal_volume
18pub_type
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