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The emerging genetic architecture of type 2 diabetes.

Abstract：

:Type 2 diabetes is a genetically heterogeneous disease, with several relatively rare monogenic forms and a number of more common forms resulting from a complex interaction of genetic and environmental factors. Previous studies using a candidate gene approach, family linkage studies, and gene expression profiling uncovered a number of type 2 genes, but the genetic basis of common type 2 diabetes remained unknown. Recently, a new window has opened on defining potential type 2 diabetes genes through genome-wide SNP association studies of very large populations of individuals with diabetes. This review explores the pathway leading to discovery of these genetic effects, the impact of these genetic loci on diabetes risk, the potential mechanisms of action of the genes to alter glucose homeostasis, and the limitations of these studies in defining the role of genetics in this important disease.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Doria A,Patti ME,Kahn CR

doi

10.1016/j.cmet.2008.08.006

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

186-200

issue

3

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(08)00247-7

journal_volume

8

pub_type

杂志文章,评审

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