Abstract:
:In this issue of Cell Metabolism, Macdougall et al. (2018) identify two subsets of conventional dendritic cells in visceral adipose tissue and demonstrate that these subsets engage distinct adipocyte-associated signaling pathways to drive their tolerogenic phenotypes in the lean state.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
LaMarche NM,Lynch Ldoi
10.1016/j.cmet.2018.02.014subject
Has Abstractpub_date
2018-03-06 00:00:00pages
485-486issue
3eissn
1550-4131issn
1932-7420pii
S1550-4131(18)30125-6journal_volume
27pub_type
评论,杂志文章相关文献
Cell Metabolism文献大全abstract::Bile acid metabolism is tightly controlled due to the toxic effects of bile acid overload. In this issue, research from the Feng lab reports Shp2 as a novel integrator of hepatic bile acid and FGF15/FGF19 signaling, adding another layer of complexity to the control of bile acid biosynthesis. ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2014.07.019
更新日期:2014-08-05 00:00:00
abstract::The fat mass and obesity-associated (FTO) gene was placed center stage when common intronic variants within the gene were robustly associated with human obesity. Murine models of perturbed Fto expression have shown effects on body weight and composition. However, a clear understanding of the link between FTO intronic ...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2014.09.010
更新日期:2014-11-04 00:00:00
abstract::Cyclic AMP (cAMP) and Ca(2+) are key regulators of exocytosis in many cells, including insulin-secreting beta cells. Glucose-stimulated insulin secretion from beta cells is pulsatile and involves oscillations of the cytoplasmic Ca(2+) concentration ([Ca(2+)](i)), but little is known about the detailed kinetics of cAMP...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.06.003
更新日期:2008-07-01 00:00:00
abstract::Cells can enter quiescent states in which cell cycling and growth are suspended. We find that during a long developmental arrest (quiescence) induced by starvation, newly hatched C. elegans acquire features associated with impaired proteostasis and aging: mitochondrial fission, ROS production, protein aggregation, dec...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2016.05.024
更新日期:2016-06-14 00:00:00
abstract::Type 1 diabetes is an autoimmune disease that manifests as impaired insulin secretion, with compounding complications over time. Bhatt et al. (2015) investigate protective mechanisms in survivors of type 1 diabetes by using induced pluripotent stem cells as genetic models, uncovering novel interactions between microRN...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2015.07.018
更新日期:2015-08-04 00:00:00
abstract::Regulatory T cells maintain tolerance and prevent autoimmunity, but their suppressive effects can hinder immune responses against cancer. In Nature Immunology, Maj et al., 2017 report that regulatory T cells can execute these actions through the nucleoside adenosine even after cell death. ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2017.12.013
更新日期:2018-01-09 00:00:00
abstract::BAD, a proapoptotic member of the Bcl-2 family of proteins, is regulated by phosphorylation. A recent study (Danial et al., 2008) suggests a phosphorylation-state-dependent bifunctional role of BAD in the regulation of glucose-stimulated insulin secretion and beta cell mass. ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.03.009
更新日期:2008-04-01 00:00:00
abstract::Reductionist in vitro T cell assays have identified metabolic pathways critical for T cell function within the tumor microenvironment. We discuss the challenges of testing these concepts using in vivo tumor models. ...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2018.07.009
更新日期:2018-08-07 00:00:00
abstract::Mammalian organs are nourished by nutrients carried by the blood circulation. These nutrients originate from diet and internal stores, and can undergo various interconversions before their eventual use as tissue fuel. Here we develop isotope tracing, mass spectrometry, and mathematical analysis methods to determine th...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.07.013
更新日期:2020-10-06 00:00:00
abstract::In the past 3 years, we have seen a flurry of publications on single-cell RNA sequencing (RNA-seq) analyses of pancreatic islets from mouse and human. This technology holds the promise to refine cell-type signatures and discover cellular heterogeneity among the canonical endocrine cell types such as the glucagon-produ...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2018.11.016
更新日期:2019-03-05 00:00:00
abstract::Long non-coding RNAs (lncRNAs) constitute a significant portion of mammalian genome, yet the physiological importance of lncRNAs is largely unknown. Here, we identify a liver-enriched lncRNA in mouse that we term liver-specific triglyceride regulator (lncLSTR). Mice with a liver-specific depletion of lncLSTR exhibit a...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.02.004
更新日期:2015-03-03 00:00:00
abstract::Signaling cascades during adipogenesis culminate in the expression of two essential adipogenic factors, PPARgamma and C/EBPalpha. Here we demonstrate that the IRE1alpha-XBP1 pathway, the most conserved branch of the unfolded protein response (UPR), is indispensable for adipogenesis. Indeed, XBP1-deficient mouse embryo...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2009.04.009
更新日期:2009-06-01 00:00:00
abstract::Glia-neuron interactions underlie a number of homeostatic processes in the brain. In this issue of Cell Metabolism, Li et al. (2020) demonstrate that the regeneration of central nervous system axons is accelerated through modulation of neuronal GABA-B receptor activity by metabolic energy intermediaries released from ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.10.009
更新日期:2020-11-03 00:00:00
abstract::Cutting down calories prolongs life, but how this works remains largely unknown. A recent study in Nature (Mair et al., 2011) shows that life span extension triggered by the energy-sensing protein kinase AMPK is mediated by an evolutionarily conserved transcriptional circuit involving CRTC-1 and CREB. ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2011.03.012
更新日期:2011-04-06 00:00:00
abstract::Serotonin (5-HT) and leptin play important roles in the modulation of energy balance. Here we investigated mechanisms by which leptin might interact with CNS 5-HT pathways to influence appetite. Although some leptin receptor (LepRb) neurons lie close to 5-HT neurons in the dorsal raphe (DR), 5-HT neurons do not expres...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2011.03.016
更新日期:2011-05-04 00:00:00
abstract::The diurnally active fruit flies prefer a major meal in the morning. Feeding the flies in the evening uncouples their metabolic cycle from circadian activity rhythms. A paper by Xu et al. in this issue of Cell Metabolism found that such uncoupled rhythms reduce egg laying. ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2011.05.003
更新日期:2011-06-08 00:00:00
abstract::Exercise produces many beneficial effects on brain health, in part by increasing hippocampal BDNF levels; however, the mechanism underlying BDNF gene regulation remains unknown. In this issue of Cell Metabolism, Wrann et al. (2013) show that exercise induces hippocampal Bdnf expression by stimulating expression of FND...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2013.10.008
更新日期:2013-11-05 00:00:00
abstract::Age-related loss of muscle mass and force (sarcopenia) contributes to disability and increased mortality. Ryanodine receptor 1 (RyR1) is the skeletal muscle sarcoplasmic reticulum calcium release channel required for muscle contraction. RyR1 from aged (24 months) rodents was oxidized, cysteine-nitrosylated, and deplet...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2011.05.014
更新日期:2011-08-03 00:00:00
abstract::The biogenesis and function of the mitochondrial respiratory chain (RC) involve the organization of RC enzyme complexes in supercomplexes or respirasomes through an unknown biosynthetic process. This leads to structural interdependences between RC complexes, which are highly relevant from biological and biomedical per...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2012.01.015
更新日期:2012-03-07 00:00:00
abstract::Altered metabolic function is common in stressed immune cells, but alteration in brain microglia during neurodegeneration is not understood. In this issue, Baik et al. (2019) provide insight into microglial metabolism. They demonstrate a switch from oxidative phosphorylation to glycolysis following interaction with am...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2019.08.017
更新日期:2019-09-03 00:00:00
abstract::The isolation and biochemical characterization of lipid droplet (LD)-associated mitochondria revealed the capacity of the cell to produce and maintain distinct mitochondrial populations carrying disparate proteome and dissimilar capacities to oxidize fatty acids and pyruvate. With mitochondrial motility being a centra...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2019.02.011
更新日期:2019-04-02 00:00:00
abstract::Current understanding of microRNA (miRNA) biology is limited, and antisense oligonucleotide (ASO) inhibition of miRNAs is a powerful technique for their functionalization. To uncover the role of the liver-specific miR-122 in the adult liver, we inhibited it in mice with a 2'-O-methoxyethyl phosphorothioate ASO. miR-12...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2006.01.005
更新日期:2006-02-01 00:00:00
abstract::A hypothesis that accounts for most of the available literature on insulin-stimulated GLUT4 translocation is that insulin action controls the access of GLUT4 vesicles to a constitutively active plasma-membrane fusion process. However, using an in vitro fusion assay, we show here that fusion is not constitutively activ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2005.08.007
更新日期:2005-09-01 00:00:00
abstract::Intense noise exposure causes hearing loss by inducing degeneration of spiral ganglia neurites that innervate cochlear hair cells. Nicotinamide adenine dinucleotide (NAD(+)) exhibits axon-protective effects in cultured neurons; however, its ability to block degeneration in vivo has been difficult to establish due to i...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2014.11.003
更新日期:2014-12-02 00:00:00
abstract::Skin aging is of considerable interest from various perspectives, ranging from aesthetics to cancer development. Zhang et al. (2019) elucidate an immunological consequence of aging in the adipose layer of skin. Age-dependent increases in TGF-β signaling impair fibroblast adipogenic potential that results in impaired a...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2019.02.006
更新日期:2019-03-05 00:00:00
abstract::The importance of neuropeptides in the hypothalamus has been experimentally established. Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters glutamate and GABA are largely unknown. Synaptic vesicular transporters (VGLUTs for glutamate and VGAT for GABA) are required for ve...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2007.04.001
更新日期:2007-05-01 00:00:00
abstract::Type 2 diabetes is an epidemic disease worldwide, but it is difficult to predict its appearance in the general population. A recent study demonstrates that circulating concentrations of a small group of essential amino acids predict risk for diabetes, contributing to a recent resurgence of interest in these common ana...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2011.04.003
更新日期:2011-05-04 00:00:00
abstract::Pancreatic islet beta cell mass expands in response to certain physiological conditions such as pregnancy and obesity, but the signaling pathways involved are not well understood. Possible insights come from a newly described regulatory circuit through which obesity-enhanced kinase signaling in the liver triggers expa...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.12.009
更新日期:2009-01-07 00:00:00
abstract::High-fat diets cause peripheral leptin resistance, and dietary lipid composition affects sensitivity to leptin. We examined the role of n-3 polyunsaturated fatty acid (PUFA) in peripheral leptin resistance. Dietary PUFAs (0.4% wt/wt) caused insensitivity to peripherally but not intracerebroventricularly administered l...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2005.04.004
更新日期:2005-05-01 00:00:00
abstract::Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases/mono-ADP-ribosyltransferases found in organisms ranging from bacteria to humans. Their dependence on nicotinamide adenine dinucleotide (NAD+) links their activity to cellular metabolic status. In bacteria, the sirtuin CobB regulates ...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2007.11.006
更新日期:2008-02-01 00:00:00