Abstract：
:Current understanding of microRNA (miRNA) biology is limited, and antisense oligonucleotide (ASO) inhibition of miRNAs is a powerful technique for their functionalization. To uncover the role of the liver-specific miR-122 in the adult liver, we inhibited it in mice with a 2'-O-methoxyethyl phosphorothioate ASO. miR-122 inhibition in normal mice resulted in reduced plasma cholesterol levels, increased hepatic fatty-acid oxidation, and a decrease in hepatic fatty-acid and cholesterol synthesis rates. Activation of the central metabolic sensor AMPK was also increased. miR-122 inhibition in a diet-induced obesity mouse model resulted in decreased plasma cholesterol levels and a significant improvement in liver steatosis, accompanied by reductions in several lipogenic genes. These results implicate miR-122 as a key regulator of cholesterol and fatty-acid metabolism in the adult liver and suggest that miR-122 may be an attractive therapeutic target for metabolic disease.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Esau C,Davis S,Murray SF,Yu XX,Pandey SK,Pear M,Watts L,Booten SL,Graham M,McKay R,Subramaniam A,Propp S,Lollo BA,Freier S,Bennett CF,Bhanot S,Monia BPdoi
10.1016/j.cmet.2006.01.005keywords:
subject
Has Abstractpub_date
2006-02-01 00:00:00pages
87-98issue
2eissn
1550-4131issn
1932-7420pii
S1550-4131(06)00029-5journal_volume
3pub_type
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