Reversible Age-Related Phenotypes Induced during Larval Quiescence in C. elegans.

Abstract:

:Cells can enter quiescent states in which cell cycling and growth are suspended. We find that during a long developmental arrest (quiescence) induced by starvation, newly hatched C. elegans acquire features associated with impaired proteostasis and aging: mitochondrial fission, ROS production, protein aggregation, decreased proteotoxic-stress resistance, and at the organismal level, decline of mobility and high mortality. All signs of aging but one, the presence of protein aggregates, were reversed upon return to development induced by feeding. The endoplasmic reticulum receptor IRE-1 is completely required for recovery, and the downstream transcription factor XBP-1, as well as a protein kinase, KGB-1, are partially required. Interestingly, kgb-1(-) mutants that do recover fail to reverse aging-like mitochondrial phenotypes and have a short adult lifespan. Our study describes the first pathway that reverses phenotypes of aging at the exit of prolonged quiescence.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Roux AE,Langhans K,Huynh W,Kenyon C

doi

10.1016/j.cmet.2016.05.024

subject

Has Abstract

pub_date

2016-06-14 00:00:00

pages

1113-1126

issue

6

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(16)30246-7

journal_volume

23

pub_type

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