Abstract:
:How circulating signals of hunger and satiety enter the brain to reach neurons that govern energy balance has long remained a matter of controversy and speculation. Balland et al. (2014) now elucidate molecular mechanisms by which a highly specialized hypothalamic glial cell regulates transport of leptin across the blood-brain barrier.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Gao Y,Tschöp MH,Luquet Sdoi
10.1016/j.cmet.2014.01.008subject
Has Abstractpub_date
2014-02-04 00:00:00pages
173-5issue
2eissn
1550-4131issn
1932-7420pii
S1550-4131(14)00014-Xjournal_volume
19pub_type
评论,杂志文章相关文献
Cell Metabolism文献大全abstract::Diabetes is a growing epidemic, and many patients depend on insulin injections to control the disease and minimize long-term complications. In a recent manuscript published in Science, Xie et al. (2016) generate insulin-producing cells from a somatic embryonic kidney cell line through minimal genetic modification capa...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2017.01.018
更新日期:2017-02-07 00:00:00
abstract::AS160 has emerged as a key player in insulin-mediated glucose transport through controlling GLUT4 trafficking, which is thought to be regulated by insulin-stimulated phosphorylation of sites including the 14-3-3 binding phospho-Thr649 (equivalent to Thr642 in human AS160). To define physiological roles of AS160-Thr649...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2010.12.005
更新日期:2011-01-05 00:00:00
abstract::Lipoprotein cholesterol is mobilized from lysosomes by actions of the NPC1 and NPC2 proteins. In this issue of Cell Metabolism, Harrison et al. report on identification of an NPC2-interacting protein, the Nogo-B receptor, that regulates NPC2 protein levels. NPC2 stabilization may represent a novel mechanism through wh...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2009.08.006
更新日期:2009-09-01 00:00:00
abstract::Type 1 diabetes is an autoimmune disease that manifests as impaired insulin secretion, with compounding complications over time. Bhatt et al. (2015) investigate protective mechanisms in survivors of type 1 diabetes by using induced pluripotent stem cells as genetic models, uncovering novel interactions between microRN...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2015.07.018
更新日期:2015-08-04 00:00:00
abstract::The role of microbial load during aging of the adult fruit fly Drosophila melanogaster is incompletely understood. Here we show dramatic increases in aerobic and anaerobic bacterial load during aging, both inside the body and on the surface. Scanning electron microscopy and cell staining analyses of the surface of age...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2007.06.006
更新日期:2007-08-01 00:00:00
abstract::Despite the prevalence of obesity and its related diseases, the signaling pathways for appetite control and satiety are not clearly understood. Here we report C. elegans quiescence behavior, a cessation of food intake and movement that is possibly a result of satiety. C. elegans quiescence shares several characteristi...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.01.005
更新日期:2008-03-01 00:00:00
abstract::The contribution of interleukin (IL)-6 signaling in obesity-induced inflammation remains controversial. To specifically define the role of hepatic IL-6 signaling in insulin action and resistance, we have generated mice with hepatocyte-specific IL-6 receptor (IL-6R) alpha deficiency (IL-6Ralpha(L-KO) mice). These anima...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2010.06.011
更新日期:2010-09-08 00:00:00
abstract::Most animal models of obesity and hyperinsulinemia are associated with increased vagal cholinergic activity. The M3 muscarinic acetylcholine receptor subtype is widely expressed in the brain and peripheral tissues and plays a key role in mediating the physiological effects of vagal activation. Here, we tested the hypo...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2006.09.008
更新日期:2006-11-01 00:00:00
abstract::Nutritional and pharmacological stimuli can dramatically alter the cellular phenotypes in white adipose tissue (WAT). Utilizing genetic lineage tracing techniques, we demonstrate that brown adipocytes (BA) that are induced by β3-adrenergic receptor activation in abdominal WAT arise from the proliferation and different...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2012.03.009
更新日期:2012-04-04 00:00:00
abstract::Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleus (Arc) is critical for the contr...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2013.01.006
更新日期:2013-02-05 00:00:00
abstract::Current evidence suggests that hypothalamic fatty acid metabolism may play a role in regulating food intake; however, confirmation that it is a physiologically relevant regulatory system of feeding is still incomplete. Here, we use pharmacological and genetic approaches to demonstrate that the physiological orexigenic...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.03.006
更新日期:2008-05-01 00:00:00
abstract::The interaction between the immune system and endocrine cells in the pancreas is crucial for the initiation and progression of type 1 diabetes (T1D). Imaging mass cytometry (IMC) enables multiplexed assessment of the abundance and localization of more than 30 proteins on the same tissue section at 1-μm resolution. Her...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2019.01.003
更新日期:2019-03-05 00:00:00
abstract::RNA-targeted therapies represent a platform for drug discovery involving chemically modified oligonucleotides, a wide range of cellular RNAs, and a novel target-binding motif, Watson-Crick base pairing. Numerous hurdles considered by many to be impassable have been overcome. Today, four RNA-targeted therapies are appr...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2018.03.004
更新日期:2018-04-03 00:00:00
abstract::Global reduction in insulin signaling has been linked to extended life span in a range of organisms. New work on mice with brain-specific or whole-body reductions in insulin receptor substrate 2 (IRS2) (Taguchi et al., 2007) points to a role for insulin/IGF-1 signaling in the central control of mammalian aging. ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2007.08.007
更新日期:2007-09-01 00:00:00
abstract::Fat and muscle lipolysis involves functional interactions of adipose triglyceride lipase (ATGL), α-β hydrolase domain-containing protein 5 (ABHD5), and tissue-specific perilipins 1 and 5 (PLIN1 and PLIN5). ABHD5 potently activates ATGL, but this lipase-promoting activity is suppressed when ABHD5 is bound to PLIN prote...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.08.023
更新日期:2015-11-03 00:00:00
abstract::Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are major phospholipids in mammalian membranes. In liver, PC is synthesized via the choline pathway or by methylation of PE via phosphatidylethanolamine N-methyltransferase (PEMT). Pemt(-/-) mice fed a choline-deficient (CD) diet develop rapid steatohepatitis ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2006.03.007
更新日期:2006-05-01 00:00:00
abstract::Reporting in Cell Metabolism, Pflimlin et al. recently found no beneficial effect of PAHSAs on glucose control in mice on several high-fat diets. Kuda cautions that due to methodological differences, the data must be carefully reinterpreted, emphasizing that olive oil contains high amounts of FAHFAs, potentially maski...
journal_title:Cell metabolism
pub_type: 评论,信件
doi:10.1016/j.cmet.2018.09.006
更新日期:2018-10-02 00:00:00
abstract::Cells can enter quiescent states in which cell cycling and growth are suspended. We find that during a long developmental arrest (quiescence) induced by starvation, newly hatched C. elegans acquire features associated with impaired proteostasis and aging: mitochondrial fission, ROS production, protein aggregation, dec...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2016.05.024
更新日期:2016-06-14 00:00:00
abstract::Studying ciliopathies, like the Bardet-Biedl syndrome (BBS), allow the identification of signaling pathways potentially involved in common diseases, sharing phenotypic features like obesity or type 2 diabetes. Given the close association between obesity and insulin resistance, obese BBS patients would be expected to b...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2012.08.005
更新日期:2012-09-05 00:00:00
abstract::Intestinal sugar sensing has an appetite-stimulating action that enhances preferences for sweets. Han et al. (2016) report that duodenal-jejunal bypass surgery reduces sweet appetite by reducing sugar-induced dopamine release in the dorsal striatum. ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2015.12.013
更新日期:2016-01-12 00:00:00
abstract::Small-molecule ligands of nuclear hormone receptors (NHRs) govern the transcriptional regulation of metazoan development, cell differentiation, and metabolism. However, the physiological ligands of many NHRs remain poorly characterized, primarily due to lack of robust analytical techniques. Using comparative metabolom...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2013.11.024
更新日期:2014-01-07 00:00:00
abstract::Cholesteryl ester accumulation by macrophages is a critical early event in atherogenesis. To test the hypothesis that sterol loading promotes foam cell formation and vascular disease by perturbing a network of interacting proteins, we used a global approach to identify proteins that are differentially expressed when m...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2010.01.003
更新日期:2010-02-03 00:00:00
abstract::Nucleotide-specific isoforms of the tricarboxylic acid (TCA) cycle enzyme succinyl-CoA synthetase (SCS) catalyze substrate-level synthesis of mitochondrial GTP (mtGTP) and ATP (mtATP). While mtATP yield from glucose metabolism is coupled with oxidative phosphorylation and can vary, each molecule of glucose metabolized...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2007.02.008
更新日期:2007-04-01 00:00:00
abstract::Obese adipose tissue is characterized by infiltration of macrophages. We and others recently showed that a specific subset of macrophages is recruited to obese adipose and muscle tissue. This subset expresses CD11c and produces high levels of proinflammatory cytokines that are linked to the development of obesity-asso...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.08.015
更新日期:2008-10-01 00:00:00
abstract::We investigated relationships among immune, metabolic, and sleep abnormalities in mice with non-metastatic mammary cancer. Tumor-bearing mice displayed interleukin-6 (IL-6)-mediated peripheral inflammation, coincident with altered hepatic glucose processing and sleep. Tumor-bearing mice were hyperphagic, had reduced s...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2018.04.021
更新日期:2018-07-03 00:00:00
abstract::It is still unclear if the ability of key regulators of actin cytoskeletal remodeling to influence lipid metabolism contributes to kidney injury. In this issue of Cell Metabolism, Fu et al. (2020) show that junctional adhesion molecule-like (JAML) is a novel mediator of glomerular disease progression while suggesting ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2020.11.002
更新日期:2020-12-01 00:00:00
abstract::VEGF (vascular endothelial growth factor) signaling inhibitors are widely used in different cancer types; however, patient selection remains a challenge. Analyses of samples from a phase III clinical trial in metastatic colorectal cancer testing chemotherapy versus chemotherapy with the small molecule VEGF receptors i...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.10.015
更新日期:2016-01-12 00:00:00
abstract::Gestational diabetes (GDM) is caused by failure of islet β cells to meet the increased insulin requirements of pregnancy. Recently, Prentice et al. (2014) discovered a 7-fold elevation of the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanopropanoic acid (CMPF) in plasma of women with GDM and showed th...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2014.03.020
更新日期:2014-04-01 00:00:00
abstract::Metabolic reprogramming plays an important role in supporting tumor growth. However, little is known about the metabolic alterations that promote cancer metastasis. In this study, we identify acyl-CoA thioesterase 12 (ACOT12) as a key player in hepatocellular carcinoma (HCC) metastasis. The expression of ACOT12 is sig...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2018.12.019
更新日期:2019-04-02 00:00:00
abstract::Mitochondria undergo architectural/functional changes in response to metabolic inputs. How this process is regulated in physiological feeding/fasting states remains unclear. Here we show that mitochondrial dynamics (notably fission and mitophagy) and biogenesis are transcriptional targets of the circadian regulator Bm...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.08.006
更新日期:2015-10-06 00:00:00