Abstract:
:Oxidants are thought to damage cells, and stem cells are viewed as particularly vulnerable to oxidative stress. Now, a new study (Morimoto et al., 2013) suggests that the self-renewal of certain stem cells may actually require reactive oxygen species (ROS).
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Liu J,Finkel Tdoi
10.1016/j.cmet.2013.06.007subject
Has Abstractpub_date
2013-07-02 00:00:00pages
1-2issue
1eissn
1550-4131issn
1932-7420pii
S1550-4131(13)00251-9journal_volume
18pub_type
评论,杂志文章相关文献
Cell Metabolism文献大全abstract::GCN2 is a sensor of amino acid deprivation that triggers a repression of global protein synthesis while simultaneously inducing translation of specific proteins. In this issue of Cell Metabolism, Guo and Cavener (2007) present a much broader role for GCN2 in controlling lipid homeostasis in response to amino acid depr...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2007.01.010
更新日期:2007-02-01 00:00:00
abstract::Reporting in Cell Metabolism, Pflimlin et al. recently found no beneficial effect of PAHSAs on glucose control in mice on several high-fat diets. Kuda cautions that due to methodological differences, the data must be carefully reinterpreted, emphasizing that olive oil contains high amounts of FAHFAs, potentially maski...
journal_title:Cell metabolism
pub_type: 评论,信件
doi:10.1016/j.cmet.2018.09.006
更新日期:2018-10-02 00:00:00
abstract::In normal physiology, end-products of metabolism are excreted from the body. In tumors, these metabolic wastes accumulate due to deregulated metabolism and vascular insufficiency. Spinelli et al. (2017) show that breast cancer cells adapt to ammonia buildup by recycling it for amino acid synthesis, which can support c...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2017.11.008
更新日期:2017-12-05 00:00:00
abstract::Plasticity in growth and reproductive behavior is found in many vertebrate species, but is common in male teleost fish. Typically, "bourgeois" males are considerably larger and defend breeding territories while "parasitic" variants are small and use opportunistic breeding strategies. The P locus mediates this phenotyp...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2011.12.014
更新日期:2012-02-08 00:00:00
abstract::Evolution favored individuals with superior cognitive and physical abilities under conditions of limited food sources, and brain function can therefore be optimized by intermittent dietary energy restriction (ER) and exercise. Such energetic challenges engage adaptive cellular stress-response signaling pathways in neu...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2012.08.012
更新日期:2012-12-05 00:00:00
abstract::As a preview of the upcoming Cell Symposium on Exercise Metabolism in Gothenburg, Sweden, May 21-23 (http://cell-symposia.com/exercisemetabolism-2017/), several of our speakers and other Cell Press exercise enthusiasts share a wide range of experiences from bench pressing goals to bench research insights. ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2017.04.024
更新日期:2017-05-02 00:00:00
abstract::Glucagon drives hepatic gluconeogenesis and maintains blood glucose levels during fasting. The mechanism that attenuates glucagon action following refeeding is not understood. The present study demonstrates an increase in perivenous liver hypoxia immediately after feeding, which stabilizes hypoxia-inducible factor 2α ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2016.01.004
更新日期:2016-03-08 00:00:00
abstract::Common variants in WNT pathway genes have been associated with bone mass and fat distribution, the latter predicting diabetes and cardiovascular disease risk. Rare mutations in the WNT co-receptors LRP5 and LRP6 are similarly associated with bone and cardiometabolic disorders. We investigated the role of LRP5 in human...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.01.009
更新日期:2015-02-03 00:00:00
abstract::The molecular mechanisms of angiogenesis in relation to adipose tissue metabolism remain poorly understood. Here, we show that exposure of mice to cold led to activation of angiogenesis in both white and brown adipose tissues. In the inguinal depot, cold exposure resulted in elevated expression levels of brown-fat-ass...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.11.009
更新日期:2009-01-07 00:00:00
abstract::In flies, ecdysone integrates growth with developmental transitions by antagonizing insulin signaling, which links growth with nutritional status. Work in Developmental Cell (Delanoue et. al, 2010) finds that ecdysone represses the transcription factor Myc in the larval fat body to inhibit systemic growth, revealing a...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2010.06.003
更新日期:2010-07-07 00:00:00
abstract::Using molecular, biochemical, and untargeted stable isotope tracing approaches, we identify a previously unappreciated glutamine-derived α-ketoglutarate (αKG) energy-generating anaplerotic flux to be critical in mitochondrial DNA (mtDNA) mutant cells that harbor human disease-associated oxidative phosphorylation defec...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2018.03.002
更新日期:2018-05-01 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in Western societies, affecting one in four adults in the USA, and is strongly associated with hepatic insulin resistance, a major risk factor in the pathogenesis of type 2 diabetes. Although the cellular mechanisms underlying this...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2012.03.005
更新日期:2012-05-02 00:00:00
abstract::The endocannabinoid system (ECS) plays a critical role in obesity development. The pharmacological blockade of cannabinoid receptor type 1 (CB(1)) has been shown to reduce body weight and to alleviate obesity-related metabolic disorders. An unsolved question is at which anatomical level CB(1) modulates energy balance ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2010.02.015
更新日期:2010-04-07 00:00:00
abstract::In this issue of Cell Metabolism, Macdougall et al. (2018) identify two subsets of conventional dendritic cells in visceral adipose tissue and demonstrate that these subsets engage distinct adipocyte-associated signaling pathways to drive their tolerogenic phenotypes in the lean state. ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2018.02.014
更新日期:2018-03-06 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Liver samples from morbidly obese patients (n = 45) with all stages of NAFLD and controls (n = 18) were analyzed by array-based DNA methylation and mRNA expression profiling. NAFLD-specific expression and me...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2013.07.004
更新日期:2013-08-06 00:00:00
abstract::Advances in neuro-technology for mapping, manipulating, and monitoring molecularly defined cell types are rapidly advancing insight into neural circuits that regulate appetite. Here, we review these important tools and their applications in circuits that control food seeking and consumption. Technical capabilities pro...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2015.12.002
更新日期:2016-02-09 00:00:00
abstract::Conservation of the rapamycin-sensitive TOR signaling network among eukaryotes has been instrumental to the rapid progress made in this field in recent years. A recent report in Molecular Cell (Urban et al., 2007) now extends this conservation to include Sch9, an AGC protein kinase family member from S. cerevisiae, wh...
journal_title:Cell metabolism
pub_type: 评论,杂志文章,评审
doi:10.1016/j.cmet.2007.06.009
更新日期:2007-07-01 00:00:00
abstract::Peroxisomes play a central role in lipid metabolism, and their function depends on molecular oxygen. Low oxygen tension or von Hippel-Lindau (Vhl) tumor suppressor loss is known to stabilize hypoxia-inducible factors alpha (Hif-1α and Hif-2α) to mediate adaptive responses, but it remains unknown if peroxisome homeosta...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2014.09.017
更新日期:2014-11-04 00:00:00
abstract::By locally infecting epididymal adipocytes of obese diabetic mice with the uncoupling protein-1 transgene, Yamada et al. (2006[this issue of Cell Metabolism]) unexpectedly induce leptin sensitivity with hypophagia and improvement in abnormal glucose and lipid abnormalities. ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2006.02.005
更新日期:2006-03-01 00:00:00
abstract::Elevated levels of tumor necrosis factor (TNFalpha) are implicated in the development of insulin resistance, but the mechanisms mediating these chronic effects are not completely understood. We demonstrate that TNFalpha signaling through TNF receptor (TNFR) 1 suppresses AMPK activity via transcriptional upregulation o...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2006.11.005
更新日期:2006-12-01 00:00:00
abstract::Serotonin (5-HT) and leptin play important roles in the modulation of energy balance. Here we investigated mechanisms by which leptin might interact with CNS 5-HT pathways to influence appetite. Although some leptin receptor (LepRb) neurons lie close to 5-HT neurons in the dorsal raphe (DR), 5-HT neurons do not expres...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2011.03.016
更新日期:2011-05-04 00:00:00
abstract::Skeletal and cardiac muscle depend on high turnover of ATP made by mitochondria in order to contract efficiently. The transcriptional coactivator PGC-1alpha has been shown to function as a major regulator of mitochondrial biogenesis and respiration in both skeletal and cardiac muscle, but this has been based only on g...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2005.03.002
更新日期:2005-04-01 00:00:00
abstract::The conversion of lipolysis-derived fatty acids into ketone bodies (ketogenesis) is a crucial metabolic adaptation to prolonged periods of food scarcity. The process occurs primarily in liver mitochondria and is initiated by fatty-acid-mediated stimulation of the ligand-operated transcription factor, peroxisome prolif...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2018.09.014
更新日期:2019-01-08 00:00:00
abstract::Genetic conservation allows ancient features of fat storage endocrine pathways to be explored in C. elegans. Multiple studies have used Nile red or BODIPY-labeled fatty acids to identify regulators of fat mass. When mixed with their food, E. coli bacteria, Nile red, and BODIPY-labeled fatty acids stain multiple spheri...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2009.10.002
更新日期:2009-11-01 00:00:00
abstract::Physical performance relies on the concerted action of myriad responses, many of which are under circadian clock control. Little is known, however, regarding the time-dependent effect on exercise performance at the molecular level. We found that both mice and humans exhibit daytime variance in exercise capacity betwee...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2019.03.012
更新日期:2019-07-02 00:00:00
abstract::Macrophages infiltrate adipose tissue in obesity and are involved in the induction of inflammation, thereby contributing to the development of obesity-associated metabolic disorders. Here, we show that the macrophage-derived soluble protein AIM is endocytosed into adipocytes via CD36. Within adipocytes, AIM associates...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2010.04.013
更新日期:2010-06-09 00:00:00
abstract::Global reduction in insulin signaling has been linked to extended life span in a range of organisms. New work on mice with brain-specific or whole-body reductions in insulin receptor substrate 2 (IRS2) (Taguchi et al., 2007) points to a role for insulin/IGF-1 signaling in the central control of mammalian aging. ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2007.08.007
更新日期:2007-09-01 00:00:00
abstract::How circulating signals of hunger and satiety enter the brain to reach neurons that govern energy balance has long remained a matter of controversy and speculation. Balland et al. (2014) now elucidate molecular mechanisms by which a highly specialized hypothalamic glial cell regulates transport of leptin across the bl...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2014.01.008
更新日期:2014-02-04 00:00:00
abstract::Glucose and hormone responsiveness of pancreatic β cells is acquired during postnatal maturation and is critical for appropriate insulin secretion. In a recent issue of Cell Metabolism, Yoshihara et al. (2016) report that estrogen-related receptor γ (ERRγ) promotes functional maturation of both mouse neonatal β cells ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2016.04.026
更新日期:2016-05-10 00:00:00
abstract::Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases/mono-ADP-ribosyltransferases found in organisms ranging from bacteria to humans. Their dependence on nicotinamide adenine dinucleotide (NAD+) links their activity to cellular metabolic status. In bacteria, the sirtuin CobB regulates ...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2007.11.006
更新日期:2008-02-01 00:00:00