Exercise Metabolism.


:As a preview of the upcoming Cell Symposium on Exercise Metabolism in Gothenburg, Sweden, May 21-23 (http://cell-symposia.com/exercisemetabolism-2017/), several of our speakers and other Cell Press exercise enthusiasts share a wide range of experiences from bench pressing goals to bench research insights.


Cell Metab


Cell metabolism





Has Abstract


2017-05-02 00:00:00














  • Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia.

    abstract::Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lip...

    journal_title:Cell metabolism

    pub_type: 信件


    authors: Bekkering S,Stiekema LCA,Bernelot Moens S,Verweij SL,Novakovic B,Prange K,Versloot M,Roeters van Lennep JE,Stunnenberg H,de Winther M,Stroes ESG,Joosten LAB,Netea MG,Riksen NP

    更新日期:2019-07-02 00:00:00

  • A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer.

    abstract::We investigated relationships among immune, metabolic, and sleep abnormalities in mice with non-metastatic mammary cancer. Tumor-bearing mice displayed interleukin-6 (IL-6)-mediated peripheral inflammation, coincident with altered hepatic glucose processing and sleep. Tumor-bearing mice were hyperphagic, had reduced s...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Borniger JC,Walker Ii WH,Surbhi,Emmer KM,Zhang N,Zalenski AA,Muscarella SL,Fitzgerald JA,Smith AN,Braam CJ,TinKai T,Magalang UJ,Lustberg MB,Nelson RJ,DeVries AC

    更新日期:2018-07-03 00:00:00

  • BBS-induced ciliary defect enhances adipogenesis, causing paradoxical higher-insulin sensitivity, glucose usage, and decreased inflammatory response.

    abstract::Studying ciliopathies, like the Bardet-Biedl syndrome (BBS), allow the identification of signaling pathways potentially involved in common diseases, sharing phenotypic features like obesity or type 2 diabetes. Given the close association between obesity and insulin resistance, obese BBS patients would be expected to b...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Marion V,Mockel A,De Melo C,Obringer C,Claussmann A,Simon A,Messaddeq N,Durand M,Dupuis L,Loeffler JP,King P,Mutter-Schmidt C,Petrovsky N,Stoetzel C,Dollfus H

    更新日期:2012-09-05 00:00:00

  • Fibrosis and adipose tissue dysfunction.

    abstract::Fibrosis is increasingly appreciated as a major player in adipose tissue dysfunction. In rapidly expanding adipose tissue, pervasive hypoxia leads to an induction of HIF1α that in turn leads to a potent profibrotic transcriptional program. The pathophysiological impact of adipose tissue fibrosis is likely to play an e...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审


    authors: Sun K,Tordjman J,Clément K,Scherer PE

    更新日期:2013-10-01 00:00:00

  • Increased internal and external bacterial load during Drosophila aging without life-span trade-off.

    abstract::The role of microbial load during aging of the adult fruit fly Drosophila melanogaster is incompletely understood. Here we show dramatic increases in aerobic and anaerobic bacterial load during aging, both inside the body and on the surface. Scanning electron microscopy and cell staining analyses of the surface of age...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Ren C,Webster P,Finkel SE,Tower J

    更新日期:2007-08-01 00:00:00

  • Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.

    abstract::Current evidence suggests that hypothalamic fatty acid metabolism may play a role in regulating food intake; however, confirmation that it is a physiologically relevant regulatory system of feeding is still incomplete. Here, we use pharmacological and genetic approaches to demonstrate that the physiological orexigenic...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: López M,Lage R,Saha AK,Pérez-Tilve D,Vázquez MJ,Varela L,Sangiao-Alvarellos S,Tovar S,Raghay K,Rodríguez-Cuenca S,Deoliveira RM,Castañeda T,Datta R,Dong JZ,Culler M,Sleeman MW,Alvarez CV,Gallego R,Lelliott CJ,Carlin

    更新日期:2008-05-01 00:00:00

  • The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity.

    abstract::Type 2 cytokines are important signals triggering biogenesis of thermogenic beige adipocytes in white adipose tissue (WAT) during cold acclimation. However, how cold activates type 2 immunity in WAT remains obscure. Here we show that cold-induced type 2 immune responses and beiging in subcutaneous WAT (scWAT) are abro...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Huang Z,Zhong L,Lee JTH,Zhang J,Wu D,Geng L,Wang Y,Wong CM,Xu A

    更新日期:2017-09-05 00:00:00

  • The cancer-associated FGFR4-G388R polymorphism enhances pancreatic insulin secretion and modifies the risk of diabetes.

    abstract::The fibroblast growth factor receptor 4 (FGFR4)-R388 single-nucleotide polymorphism has been associated with cancer risk and prognosis. Here we show that the FGFR4-R388 allele yields a receptor variant that preferentially promotes STAT3/5 signaling. This STAT activation transcriptionally induces Grb14 in pancreatic en...

    journal_title:Cell metabolism

    pub_type: 杂志文章,收录出版


    authors: Ezzat S,Zheng L,Florez JC,Stefan N,Mayr T,Hliang MM,Jablonski K,Harden M,Stančáková A,Laakso M,Haring HU,Ullrich A,Asa SL

    更新日期:2013-06-04 00:00:00

  • Resistance to high-fat diet-induced obesity and insulin resistance in mice with very long-chain acyl-CoA dehydrogenase deficiency.

    abstract::Mitochondrial fatty acid oxidation provides an important energy source for cellular metabolism, and decreased mitochondrial fatty acid oxidation has been implicated in the pathogenesis of type 2 diabetes. Paradoxically, mice with an inherited deficiency of the mitochondrial fatty acid oxidation enzyme, very long-chain...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Zhang D,Christianson J,Liu ZX,Tian L,Choi CS,Neschen S,Dong J,Wood PA,Shulman GI

    更新日期:2010-05-05 00:00:00

  • Mitochondrial GTP regulates glucose-stimulated insulin secretion.

    abstract::Nucleotide-specific isoforms of the tricarboxylic acid (TCA) cycle enzyme succinyl-CoA synthetase (SCS) catalyze substrate-level synthesis of mitochondrial GTP (mtGTP) and ATP (mtATP). While mtATP yield from glucose metabolism is coupled with oxidative phosphorylation and can vary, each molecule of glucose metabolized...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Kibbey RG,Pongratz RL,Romanelli AJ,Wollheim CB,Cline GW,Shulman GI

    更新日期:2007-04-01 00:00:00

  • Reproduction, fat metabolism, and life span: what is the connection?

    abstract::Reduced reproduction is associated with increased fat storage and prolonged life span in multiple organisms, but the underlying regulatory mechanisms remain poorly understood. Recent studies in several species provide evidence that reproduction, fat metabolism, and longevity are directly coupled. For instance, germlin...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审


    authors: Hansen M,Flatt T,Aguilaniu H

    更新日期:2013-01-08 00:00:00

  • Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes.

    abstract::The interaction between the immune system and endocrine cells in the pancreas is crucial for the initiation and progression of type 1 diabetes (T1D). Imaging mass cytometry (IMC) enables multiplexed assessment of the abundance and localization of more than 30 proteins on the same tissue section at 1-μm resolution. Her...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Wang YJ,Traum D,Schug J,Gao L,Liu C,HPAP Consortium.,Atkinson MA,Powers AC,Feldman MD,Naji A,Chang KM,Kaestner KH

    更新日期:2019-03-05 00:00:00

  • SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.

    abstract::Resveratrol induces mitochondrial biogenesis and protects against metabolic decline, but whether SIRT1 mediates these benefits is the subject of debate. To circumvent the developmental defects of germline SIRT1 knockouts, we have developed an inducible system that permits whole-body deletion of SIRT1 in adult mice. Mi...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Price NL,Gomes AP,Ling AJ,Duarte FV,Martin-Montalvo A,North BJ,Agarwal B,Ye L,Ramadori G,Teodoro JS,Hubbard BP,Varela AT,Davis JG,Varamini B,Hafner A,Moaddel R,Rolo AP,Coppari R,Palmeira CM,de Cabo R,Baur JA,Sin

    更新日期:2012-05-02 00:00:00

  • Designing β Cells.

    abstract::Diabetes is a growing epidemic, and many patients depend on insulin injections to control the disease and minimize long-term complications. In a recent manuscript published in Science, Xie et al. (2016) generate insulin-producing cells from a somatic embryonic kidney cell line through minimal genetic modification capa...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章


    authors: Hebrok M

    更新日期:2017-02-07 00:00:00

  • Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans.

    abstract::The molecular transducers of benefits from different exercise modalities remain incompletely defined. Here we report that 12 weeks of high-intensity aerobic interval (HIIT), resistance (RT), and combined exercise training enhanced insulin sensitivity and lean mass, but only HIIT and combined training improved aerobic ...

    journal_title:Cell metabolism

    pub_type: 临床试验,杂志文章


    authors: Robinson MM,Dasari S,Konopka AR,Johnson ML,Manjunatha S,Esponda RR,Carter RE,Lanza IR,Nair KS

    更新日期:2017-03-07 00:00:00

  • Central role of Mic10 in the mitochondrial contact site and cristae organizing system.

    abstract::The mitochondrial contact site and cristae organizing system (MICOS) is a conserved multi-subunit complex crucial for maintaining the characteristic architecture of mitochondria. Studies with deletion mutants identified Mic10 and Mic60 as core subunits of MICOS. Mic60 has been studied in detail; however, topogenesis a...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Bohnert M,Zerbes RM,Davies KM,Mühleip AW,Rampelt H,Horvath SE,Boenke T,Kram A,Perschil I,Veenhuis M,Kühlbrandt W,van der Klei IJ,Pfanner N,van der Laan M

    更新日期:2015-05-05 00:00:00

  • Insulin, cGMP, and TGF-beta signals regulate food intake and quiescence in C. elegans: a model for satiety.

    abstract::Despite the prevalence of obesity and its related diseases, the signaling pathways for appetite control and satiety are not clearly understood. Here we report C. elegans quiescence behavior, a cessation of food intake and movement that is possibly a result of satiety. C. elegans quiescence shares several characteristi...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: You YJ,Kim J,Raizen DM,Avery L

    更新日期:2008-03-01 00:00:00

  • Mitochondrial medicine: a metabolic perspective on the pathology of oxidative phosphorylation disorders.

    abstract::The final steps in the production of adenosine triphosphate (ATP) in mitochondria are executed by a series of multisubunit complexes and electron carriers, which together constitute the oxidative phosphorylation (OXPHOS) system. OXPHOS is under dual genetic control, with communication between the nuclear and mitochond...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审


    authors: Smeitink JA,Zeviani M,Turnbull DM,Jacobs HT

    更新日期:2006-01-01 00:00:00

  • Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults.

    abstract::Neuropeptide Y (NPY) is a potent orexigenic neuropeptide, and antagonism of NPY Y1 and NPY Y5 receptors (NPYxR) is considered a potentially important anti-obesity drug target. We tested the hypothesis that blockade of the NPY5R will lead to weight loss in humans using MK-0557, a potent, highly selective, orally active...

    journal_title:Cell metabolism

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Erondu N,Gantz I,Musser B,Suryawanshi S,Mallick M,Addy C,Cote J,Bray G,Fujioka K,Bays H,Hollander P,Sanabria-Bohórquez SM,Eng W,Långström B,Hargreaves RJ,Burns HD,Kanatani A,Fukami T,MacNeil DJ,Gottesdiener KM,Ama

    更新日期:2006-10-01 00:00:00

  • The liver--a potential new player in islet regeneration?

    abstract::Pancreatic islet beta cell mass expands in response to certain physiological conditions such as pregnancy and obesity, but the signaling pathways involved are not well understood. Possible insights come from a newly described regulatory circuit through which obesity-enhanced kinase signaling in the liver triggers expa...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Moss LG,Newgard CB

    更新日期:2009-01-07 00:00:00

  • Stem cells and oxidants: too little of a bad thing.

    abstract::Oxidants are thought to damage cells, and stem cells are viewed as particularly vulnerable to oxidative stress. Now, a new study (Morimoto et al., 2013) suggests that the self-renewal of certain stem cells may actually require reactive oxygen species (ROS). ...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章


    authors: Liu J,Finkel T

    更新日期:2013-07-02 00:00:00

  • Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis.

    abstract::PTPMT1 was the first protein tyrosine phosphatase found localized to the mitochondria, but its biological function was unknown. Herein, we demonstrate that whole body deletion of Ptpmt1 in mice leads to embryonic lethality, suggesting an indispensable role for PTPMT1 during development. Ptpmt1 deficiency in mouse embr...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Zhang J,Guan Z,Murphy AN,Wiley SE,Perkins GA,Worby CA,Engel JL,Heacock P,Nguyen OK,Wang JH,Raetz CR,Dowhan W,Dixon JE

    更新日期:2011-06-08 00:00:00

  • Toward a Molecular Definition of Leucine-Dependent mTORC1 Activation.

    abstract::The mechanistic target of rapamycin complex 1 (mTORC1) coordinates nutrient availability with cell growth. Recent reports by Sabatini and coworkers (Saxton et al., 2016; Wolfson et al., 2016) characterize a cytoplasmic amino acid receptor that couples the binding of leucine to the activation of mTORC1. ...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Abraham RT

    更新日期:2016-03-08 00:00:00

  • The emerging genetic architecture of type 2 diabetes.

    abstract::Type 2 diabetes is a genetically heterogeneous disease, with several relatively rare monogenic forms and a number of more common forms resulting from a complex interaction of genetic and environmental factors. Previous studies using a candidate gene approach, family linkage studies, and gene expression profiling uncov...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审


    authors: Doria A,Patti ME,Kahn CR

    更新日期:2008-09-01 00:00:00

  • Adult stem-like cells exclude "older" mitochondria.

    abstract::Asymmetric distribution of damaged cellular constituents may occur during mitosis, resulting in more and less pristine daughter cell pairs. In Science, Katajisto et al., (2015) report that mammary stem-like cells (SLCs) unequally apportion older mitochondria to post-division daughter cells, with the daughter containin...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章


    authors: Teitell MA

    更新日期:2015-05-05 00:00:00

  • Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling.

    abstract::Elevated levels of tumor necrosis factor (TNFalpha) are implicated in the development of insulin resistance, but the mechanisms mediating these chronic effects are not completely understood. We demonstrate that TNFalpha signaling through TNF receptor (TNFR) 1 suppresses AMPK activity via transcriptional upregulation o...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Steinberg GR,Michell BJ,van Denderen BJ,Watt MJ,Carey AL,Fam BC,Andrikopoulos S,Proietto J,Görgün CZ,Carling D,Hotamisligil GS,Febbraio MA,Kay TW,Kemp BE

    更新日期:2006-12-01 00:00:00

  • TOR signaling and S6 kinase 1: Yeast catches up.

    abstract::Conservation of the rapamycin-sensitive TOR signaling network among eukaryotes has been instrumental to the rapid progress made in this field in recent years. A recent report in Molecular Cell (Urban et al., 2007) now extends this conservation to include Sch9, an AGC protein kinase family member from S. cerevisiae, wh...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章,评审


    authors: Powers T

    更新日期:2007-07-01 00:00:00

  • Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver.

    abstract::Diurnal oscillations of gene expression controlled by the circadian clock and its connected feeding rhythm enable organisms to coordinate their physiologies with daily environmental cycles. While available techniques yielded crucial insights into regulation at the transcriptional level, much less is known about tempor...

    journal_title:Cell metabolism

    pub_type: 杂志文章


    authors: Wang J,Mauvoisin D,Martin E,Atger F,Galindo AN,Dayon L,Sizzano F,Palini A,Kussmann M,Waridel P,Quadroni M,Dulić V,Naef F,Gachon F

    更新日期:2017-01-10 00:00:00

  • Knock, knock to reset the clock: mechanosensation and circadian rhythms.

    abstract::Circadian clocks, which underlie the daily rhythms in virtually all organisms, are entrained by diurnal changes in light, temperature, nutrients, and even sound. Simoni et al. (2014) demonstrate that diurnal variation in mechanical vibrations can reset circadian clock phase, providing a potential mechanism for integra...

    journal_title:Cell metabolism

    pub_type: 评论,杂志文章


    authors: van Alphen B,Allada R

    更新日期:2014-05-06 00:00:00

  • Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding.

    abstract::The essential role of the brain in maintaining energy homeostasis has motivated the drive to define the neural circuitry that integrates external and internal stimuli to enact appropriate and consequential metabolic and behavioral responses. The hypothalamus has received significant attention in this regard given its ...

    journal_title:Cell metabolism

    pub_type: 杂志文章,评审


    authors: Waterson MJ,Horvath TL

    更新日期:2015-12-01 00:00:00