Abstract：
:The isolation and biochemical characterization of lipid droplet (LD)-associated mitochondria revealed the capacity of the cell to produce and maintain distinct mitochondrial populations carrying disparate proteome and dissimilar capacities to oxidize fatty acids and pyruvate. With mitochondrial motility being a central parameter determining mitochondrial fusion, adherence to LDs provides a mechanism by which peridroplet mitochondria (PDM) remain segregated from cytoplasmic mitochondria (CM). The existence of metabolically distinct subpopulations provides an explanation for the capacity of mitochondria within the individual cell to be involved simultaneously in fatty acid oxidation and LD formation. The mechanisms that deploy mitochondria to the LD and the dysfunctions that result from unbalanced proportions of PDM and CM remain to be explored. Understanding the roles and regulation of mitochondrial tethering to LDs offers new points of intervention in metabolic diseases.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Benador IY,Veliova M,Liesa M,Shirihai OSdoi
10.1016/j.cmet.2019.02.011subject
Has Abstractpub_date
2019-04-02 00:00:00pages
827-835issue
4eissn
1550-4131issn
1932-7420pii
S1550-4131(19)30075-0journal_volume
29pub_type
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