Abstract：
:Metabolic imaging using hyperpolarized magnetic resonance can increase the sensitivity of MRI, though its ability to inform on relevant changes to biochemistry in humans remains unclear. In this work, we image pyruvate metabolism in patients, assessing the reproducibility of delivery and conversion in the setting of primary prostate cancer. We show that the time to max of pyruvate does not vary significantly within patients undergoing two separate injections or across patients. Furthermore, we show that lactate increases with Gleason grade. RNA sequencing data demonstrate a significant increase in the predominant pyruvate uptake transporter, monocarboxylate transporter 1. Increased protein expression was also observed in regions of high lactate signal, implicating it as the driver of lactate signal in vivo. Targeted DNA sequencing for actionable mutations revealed the highest lactate occurred in patients with PTEN loss. This work identifies a potential link between actionable genomic alterations and metabolic information derived from hyperpolarized pyruvate MRI.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Granlund KL,Tee SS,Vargas HA,Lyashchenko SK,Reznik E,Fine S,Laudone V,Eastham JA,Touijer KA,Reuter VE,Gonen M,Sosa RE,Nicholson D,Guo YW,Chen AP,Tropp J,Robb F,Hricak H,Keshari KRdoi
10.1016/j.cmet.2019.08.024subject
Has Abstractpub_date
2020-01-07 00:00:00pages
105-114.e3issue
1eissn
1550-4131issn
1932-7420pii
S1550-4131(19)30498-Xjournal_volume
31pub_type
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