Abstract：
:Dietary restriction (DR) was shown to impact on tumor growth with very variable effects depending on the cancer type. However, how DR limits cancer progression remains largely unknown. Here, we demonstrate that feeding mice a low-protein (Low PROT) isocaloric diet but not a low-carbohydrate (Low CHO) diet reduced tumor growth in three independent mouse cancer models. Surprisingly, this effect relies on anticancer immunosurveillance, as depleting CD8+ T cells, antigen-presenting cells (APCs), or using immunodeficient mice prevented the beneficial effect of the diet. Mechanistically, we established that a Low PROT diet induces the unfolded protein response (UPR) in tumor cells through the activation of IRE1α and RIG1 signaling, thereby resulting in cytokine production and mounting an efficient anticancer immune response. Collectively, our data suggest that a Low PROT diet induces an IRE1α-dependent UPR in cancer cells, enhancing a CD8-mediated T cell response against tumors.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Rubio-Patiño C,Bossowski JP,De Donatis GM,Mondragón L,Villa E,Aira LE,Chiche J,Mhaidly R,Lebeaupin C,Marchetti S,Voutetakis K,Chatziioannou A,Castelli FA,Lamourette P,Chu-Van E,Fenaille F,Avril T,Passeron T,Pattersondoi
10.1016/j.cmet.2018.02.009subject
Has Abstractpub_date
2018-04-03 00:00:00pages
828-842.e7issue
4eissn
1550-4131issn
1932-7420pii
S1550-4131(18)30120-7journal_volume
27pub_type
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