Abstract：
:Peroxisomes play a central role in lipid metabolism, and their function depends on molecular oxygen. Low oxygen tension or von Hippel-Lindau (Vhl) tumor suppressor loss is known to stabilize hypoxia-inducible factors alpha (Hif-1α and Hif-2α) to mediate adaptive responses, but it remains unknown if peroxisome homeostasis and metabolism are interconnected with Hif-α signaling. By studying liver-specific Vhl, Vhl/Hif1α, and Vhl/Hif2α knockout mice, we demonstrate a regulatory function of Hif-2α signaling on peroxisomes. Hif-2α activation augments peroxisome turnover by selective autophagy (pexophagy) and thereby changes lipid composition reminiscent of peroxisomal disorders. The autophagy receptor Nbr1 localizes to peroxisomes and is likewise degraded by Hif-2α-mediated pexophagy. Furthermore, we demonstrate that peroxisome abundance is reduced in VHL-deficient human clear cell renal cell carcinomas with high HIF-2α levels. These results establish Hif-2α as a negative regulator of peroxisome abundance and metabolism and suggest a mechanism by which cells attune peroxisomal function with oxygen availability.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Walter KM,Schönenberger MJ,Trötzmüller M,Horn M,Elsässer HP,Moser AB,Lucas MS,Schwarz T,Gerber PA,Faust PL,Moch H,Köfeler HC,Krek W,Kovacs WJdoi
10.1016/j.cmet.2014.09.017subject
Has Abstractpub_date
2014-11-04 00:00:00pages
882-897issue
5eissn
1550-4131issn
1932-7420pii
S1550-4131(14)00440-9journal_volume
20pub_type
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