Abstract：
:Most mitochondrial proteins are imported by the translocase of the outer mitochondrial membrane (TOM). Tom22 functions as central receptor and transfers preproteins to the import pore. Casein kinase 2 (CK2) constitutively phosphorylates the cytosolic precursor of Tom22 at Ser44 and Ser46 and, thus, promotes its import. It is unknown whether Tom22 is regulated under different metabolic conditions. We report that CK1, which is involved in glucose-induced signal transduction, is bound to mitochondria. CK1 phosphorylates Tom22 at Thr57 and stimulates the assembly of Tom22 and Tom20. In contrast, protein kinase A (PKA), which is also activated by the addition of glucose, phosphorylates the precursor of Tom22 at Thr76 and impairs its import. Thus, PKA functions in an opposite manner to CK1 and CK2. Our results reveal that three kinases regulate the import and assembly of Tom22, demonstrating that the central receptor is a major target for the posttranslational regulation of mitochondrial protein import.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Gerbeth C,Schmidt O,Rao S,Harbauer AB,Mikropoulou D,Opalińska M,Guiard B,Pfanner N,Meisinger Cdoi
10.1016/j.cmet.2013.09.006subject
Has Abstractpub_date
2013-10-01 00:00:00pages
578-87issue
4eissn
1550-4131issn
1932-7420pii
S1550-4131(13)00374-4journal_volume
18pub_type
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