Abstract：
:Metabolomics is the systematic identification and quantitation of all metabolites in a given organism or biological sample. The enhanced resolution provided by nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS), along with powerful chemometric software, allows the simultaneous determination and comparison of thousands of chemical entities, which has lead to an expansion of small molecule biochemistry studies in bacteria, plants, and mammals. Continued development of these analytical platforms will accelerate the widespread use of metabolomics and allow further integration of small molecules into systems biology. Here, recent studies using metabolomics in xenobiotic metabolism and genetically modified mice are highlighted.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Idle JR,Gonzalez FJdoi
10.1016/j.cmet.2007.10.005subject
Has Abstractpub_date
2007-11-01 00:00:00pages
348-51issue
5eissn
1550-4131issn
1932-7420pii
S1550-4131(07)00298-7journal_volume
6pub_type
杂志文章相关文献
Cell Metabolism文献大全abstract：:Repression of mitochondrial respiration represents an evolutionarily ancient cellular adaptation to hypoxia and profoundly influences cell survival and function; however, the underlying molecular mechanisms are incompletely understood. Primarily utilizing pulmonary arterial endothelial cells as a representative hypoxi...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2009.08.015
更新日期：2009-10-01 00:00:00
abstract：:Dietary lipid digestion is critical for body fat storage control, but little is known about the regulation of genes involved in fat breakdown and absorption in the gastrointestinal tract. A Drosophila study (Sieber and Thummel, 2009 [this issue of Cell Metabolism]) now demonstrates that the orphan nuclear receptor DHR...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2009.11.004
更新日期：2009-12-01 00:00:00
abstract：:Glia-neuron interactions underlie a number of homeostatic processes in the brain. In this issue of Cell Metabolism, Li et al. (2020) demonstrate that the regeneration of central nervous system axons is accelerated through modulation of neuronal GABA-B receptor activity by metabolic energy intermediaries released from ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2020.10.009
更新日期：2020-11-03 00:00:00
abstract：:Circadian clocks regulate most aspects of physiology and metabolism. Genome-wide approaches have uncovered widespread circadian rhythms in the transcriptome, cistrome, and epigenome of mice, and now two proteomics studies in this issue (Robles et al., 2016; Wang et al., 2016) reveal extensive circadian regulation of t...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2016.12.014
更新日期：2017-01-10 00:00:00
abstract：:Leptin secreted by adipocytes acts on the brain to reduce food intake by regulating neuronal activity in the mediobasal hypothalamus (MBH). Obesity is associated with resistance to high circulating leptin levels. Here, we demonstrate that peripherally administered leptin activates its receptor (LepR) in median eminenc...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2013.12.015
更新日期：2014-02-04 00:00:00
abstract：:The molecular transducers of benefits from different exercise modalities remain incompletely defined. Here we report that 12 weeks of high-intensity aerobic interval (HIIT), resistance (RT), and combined exercise training enhanced insulin sensitivity and lean mass, but only HIIT and combined training improved aerobic ...
journal_title：Cell metabolism
pub_type： 临床试验,杂志文章
doi：10.1016/j.cmet.2017.02.009
更新日期：2017-03-07 00:00:00
abstract：:Defects in insulin secretion play a central role in the pathogenesis of type 2 diabetes, yet the mechanisms driving beta-cell dysfunction remain poorly understood, and therapies to preserve glucose-dependent insulin release are inadequate. We report a luminescent insulin secretion assay that enables large-scale invest...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2014.12.010
更新日期：2015-01-06 00:00:00
abstract：:In the past 3 years, we have seen a flurry of publications on single-cell RNA sequencing (RNA-seq) analyses of pancreatic islets from mouse and human. This technology holds the promise to refine cell-type signatures and discover cellular heterogeneity among the canonical endocrine cell types such as the glucagon-produ...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2018.11.016
更新日期：2019-03-05 00:00:00
abstract：:Mitochondrial dysfunction is a hallmark of multiple metabolic complications. Physical activity is known to increase mitochondrial content in skeletal muscle, counteracting age-related decline in muscle function and protecting against metabolic and cardiovascular complications. Here, we investigated the effect of 4 mon...
journal_title：Cell metabolism
pub_type： 临床试验,杂志文章
doi：10.1016/j.cmet.2016.11.004
更新日期：2017-02-07 00:00:00
abstract：:RNA-targeted therapies represent a platform for drug discovery involving chemically modified oligonucleotides, a wide range of cellular RNAs, and a novel target-binding motif, Watson-Crick base pairing. Numerous hurdles considered by many to be impassable have been overcome. Today, four RNA-targeted therapies are appr...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2018.03.004
更新日期：2018-04-03 00:00:00
abstract：:TRPM channels have emerged as key mediators of diverse physiological functions. However, the ionic permeability relevant to physiological function in vivo remains unclear for most members. We report that the single Drosophila TRPM gene (dTRPM) generates a conductance permeable to divalent cations, especially Zn(2+) an...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2010.08.012
更新日期：2010-10-06 00:00:00
abstract：:Obesity and atherosclerosis-related diseases account for over one-third of deaths in the western world. Controlling these conditions remains a major challenge due to an incomplete understanding of the molecular pathways involved. Here, we show that Wip1 phosphatase, a known negative regulator of Atm-dependent signalin...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2012.06.003
更新日期：2012-07-03 00:00:00
abstract：:Resveratrol induces mitochondrial biogenesis and protects against metabolic decline, but whether SIRT1 mediates these benefits is the subject of debate. To circumvent the developmental defects of germline SIRT1 knockouts, we have developed an inducible system that permits whole-body deletion of SIRT1 in adult mice. Mi...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2012.04.003
更新日期：2012-05-02 00:00:00
abstract：:Oxidative stress causes mitochondrial dysfunction and metabolic complications through unknown mechanisms. Cardiolipin (CL) is a key mitochondrial phospholipid required for oxidative phosphorylation. Oxidative damage to CL from pathological remodeling is implicated in the etiology of mitochondrial dysfunction commonly ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2010.07.003
更新日期：2010-08-04 00:00:00
abstract：:Age-related loss of muscle mass and force (sarcopenia) contributes to disability and increased mortality. Ryanodine receptor 1 (RyR1) is the skeletal muscle sarcoplasmic reticulum calcium release channel required for muscle contraction. RyR1 from aged (24 months) rodents was oxidized, cysteine-nitrosylated, and deplet...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2011.05.014
更新日期：2011-08-03 00:00:00
abstract：:Peroxisomes play a central role in lipid metabolism, and their function depends on molecular oxygen. Low oxygen tension or von Hippel-Lindau (Vhl) tumor suppressor loss is known to stabilize hypoxia-inducible factors alpha (Hif-1α and Hif-2α) to mediate adaptive responses, but it remains unknown if peroxisome homeosta...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2014.09.017
更新日期：2014-11-04 00:00:00
abstract：:Mitochondrial fission is sustained through contact with several organelles, including the endoplasmic reticulum, lysosomes, and the actin cytoskeleton. Nagashima et al. (2020) now demonstrate that PI(4)P-containing Golgi-derived vesicles also modulate mitochondrial fission, driven by Arf1 and PI(4)KIIIβ activity, iden...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2020.05.010
更新日期：2020-06-02 00:00:00
abstract：:A BMI in the normal range associates with a decreased risk of cardiometabolic disease and all-cause mortality. However, not all subjects in this BMI range have this low risk. Compared to people who are of normal weight and metabolically healthy, subjects who are of normal weight but metabolically unhealthy (∼20% of th...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2017.07.008
更新日期：2017-08-01 00:00:00
abstract：:Intestinal microbial communities regulate a range of host physiological functions, from energy harvest and glucose homeostasis to immune development and regulation. Suez et al. (2014) recently demonstrated that artificial sweeteners alter gut microbial communities, leading to glucose intolerance in both mice and human...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2014.10.012
更新日期：2014-11-04 00:00:00
abstract：:Mutations of mtDNA cause mitochondrial diseases and are implicated in age-associated diseases and aging. Pathogenic mtDNA mutations are often present in a fraction of all mtDNA copies, and it has been widely debated whether the proportion of mutant genomes or the absolute number of wild-type molecules determines if ox...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2017.07.003
更新日期：2017-08-01 00:00:00
abstract：:Obese adipose tissue is characterized by infiltration of macrophages. We and others recently showed that a specific subset of macrophages is recruited to obese adipose and muscle tissue. This subset expresses CD11c and produces high levels of proinflammatory cytokines that are linked to the development of obesity-asso...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2008.08.015
更新日期：2008-10-01 00:00:00
abstract：:Cells can enter quiescent states in which cell cycling and growth are suspended. We find that during a long developmental arrest (quiescence) induced by starvation, newly hatched C. elegans acquire features associated with impaired proteostasis and aging: mitochondrial fission, ROS production, protein aggregation, dec...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2016.05.024
更新日期：2016-06-14 00:00:00
abstract：:Cellular metabolite balance and mitochondrial function are under circadian control, but the pathways connecting the molecular clock to these functions are unclear. Peroxisome proliferator-activated receptor delta (PPARδ) enables preferential utilization of lipids as fuel during exercise and is a major driver of exerci...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2017.06.002
更新日期：2017-07-05 00:00:00
abstract：:Using molecular, biochemical, and untargeted stable isotope tracing approaches, we identify a previously unappreciated glutamine-derived α-ketoglutarate (αKG) energy-generating anaplerotic flux to be critical in mitochondrial DNA (mtDNA) mutant cells that harbor human disease-associated oxidative phosphorylation defec...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2018.03.002
更新日期：2018-05-01 00:00:00
abstract：:Light is a powerful synchronizer of the circadian rhythms, and bright light therapy is known to improve metabolic and hormonal status of circadian rhythm sleep disorders, although its mechanism is poorly understood. In the present study, we revealed that light induces gene expression in the adrenal gland via the supra...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2005.09.009
更新日期：2005-11-01 00:00:00
abstract：:Type 1 diabetes is an autoimmune disease that manifests as impaired insulin secretion, with compounding complications over time. Bhatt et al. (2015) investigate protective mechanisms in survivors of type 1 diabetes by using induced pluripotent stem cells as genetic models, uncovering novel interactions between microRN...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2015.07.018
更新日期：2015-08-04 00:00:00
abstract：:The fat mass and obesity-associated (FTO) gene was placed center stage when common intronic variants within the gene were robustly associated with human obesity. Murine models of perturbed Fto expression have shown effects on body weight and composition. However, a clear understanding of the link between FTO intronic ...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2014.09.010
更新日期：2014-11-04 00:00:00
abstract：:Whether some hypothalamic neurons have direct access to circulating metabolic cues represents a crucial question that has been intensely debated. New findings reveal that fasting promotes "leakiness" of some hypothalamic blood vessels, increasing the access of circulating factors to certain hypothalamic neurons that c...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2013.03.007
更新日期：2013-04-02 00:00:00
abstract：:While adipogenesis is known to be controlled by a complex network of transcription factors, less is known about the transcriptional cascade that initiates this process. We report here the characterization of Krüppel-like factor 4 (KLF4) as an essential early regulator of adipogenesis. Klf4 is expressed in 3T3-L1 cells...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2008.02.001
更新日期：2008-04-01 00:00:00
abstract：:CD4 T cell activation leads to proliferation and differentiation into effector (Teff) or regulatory (Treg) cells that mediate or control immunity. While each subset prefers distinct glycolytic or oxidative metabolic programs in vitro, requirements and mechanisms that control T cell glucose uptake and metabolism in viv...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2014.05.004
更新日期：2014-07-01 00:00:00
