Abstract：
:Mitochondrial dysfunction is a hallmark of multiple metabolic complications. Physical activity is known to increase mitochondrial content in skeletal muscle, counteracting age-related decline in muscle function and protecting against metabolic and cardiovascular complications. Here, we investigated the effect of 4 months of exercise training on skeletal muscle mitochondria electron transport chain complexes and supercomplexes in 26 healthy, sedentary older adults. Exercise differentially modulated respiratory complexes. Complex I was the most upregulated complex and not stoichiometrically associated to the other complexes. In contrast to the other complexes, complex I was almost exclusively found assembled in supercomplexes in muscle mitochondria. Overall, supercomplex content was increased after exercise. In particular, complexes I, III, and IV were redistributed to supercomplexes in the form of I+III2+IV. Taken together, our results provide the first evidence that exercise affects the stoichiometry of supercomplex formation in humans and thus reveal a novel adaptive mechanism for increased energy demand.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Greggio C,Jha P,Kulkarni SS,Lagarrigue S,Broskey NT,Boutant M,Wang X,Conde Alonso S,Ofori E,Auwerx J,Cantó C,Amati Fdoi
10.1016/j.cmet.2016.11.004subject
Has Abstractpub_date
2017-02-07 00:00:00pages
301-311issue
2eissn
1550-4131issn
1932-7420pii
S1550-4131(16)30582-4journal_volume
25pub_type
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