Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals.

Abstract:

:"Beige" adipocytes reside in white adipose tissue (WAT) and dissipate energy as heat. Several studies have shown that cold temperature can activate pro-opiomelanocortin-expressing (POMC) neurons and increase sympathetic neuronal tone to regulate WAT beiging. WAT, however, is traditionally known to be sparsely innervated. Details regarding the neuronal innervation and, more importantly, the propagation of the signal within the population of "beige" adipocytes are sparse. Here, we demonstrate that beige adipocytes display an increased cell-to-cell coupling via connexin 43 (Cx43) gap junction channels. Blocking of Cx43 channels by 18α-glycyrrhetinic acid decreases POMC-activation-induced adipose tissue beiging. Adipocyte-specific deletion of Cx43 reduces WAT beiging to a level similar to that observed in denervated fat pads. In contrast, overexpression of Cx43 is sufficient to promote beiging even with mild cold stimuli. These data reveal the importance of cell-to-cell communication, effective in cold-induced WAT beiging, for the propagation of limited neuronal inputs in adipose tissue.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Zhu Y,Gao Y,Tao C,Shao M,Zhao S,Huang W,Yao T,Johnson JA,Liu T,Cypess AM,Gupta O,Holland WL,Gupta RK,Spray DC,Tanowitz HB,Cao L,Lynes MD,Tseng YH,Elmquist JK,Williams KW,Lin HV,Scherer PE

doi

10.1016/j.cmet.2016.08.005

subject

Has Abstract

pub_date

2016-09-13 00:00:00

pages

420-433

issue

3

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(16)30421-1

journal_volume

24

pub_type

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