Abstract：
:Obesity is a heritable disorder, with children of obese fathers at higher risk of developing obesity. Environmental factors epigenetically influence somatic tissues, but the contribution of these factors to the establishment of epigenetic patterns in human gametes is unknown. Here, we hypothesized that weight loss remodels the epigenetic signature of spermatozoa in human obesity. Comprehensive profiling of the epigenome of sperm from lean and obese men showed similar histone positioning, but small non-coding RNA expression and DNA methylation patterns were markedly different. In a separate cohort of morbidly obese men, surgery-induced weight loss was associated with a dramatic remodeling of sperm DNA methylation, notably at genetic locations implicated in the central control of appetite. Our data provide evidence that the epigenome of human spermatozoa dynamically changes under environmental pressure and offers insight into how obesity may propagate metabolic dysfunction to the next generation.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Donkin I,Versteyhe S,Ingerslev LR,Qian K,Mechta M,Nordkap L,Mortensen B,Appel EV,Jørgensen N,Kristiansen VB,Hansen T,Workman CT,Zierath JR,Barrès Rdoi
10.1016/j.cmet.2015.11.004subject
Has Abstractpub_date
2016-02-09 00:00:00pages
369-78issue
2eissn
1550-4131issn
1932-7420pii
S1550-4131(15)00571-9journal_volume
23pub_type
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