Abstract:
:In normal physiology, end-products of metabolism are excreted from the body. In tumors, these metabolic wastes accumulate due to deregulated metabolism and vascular insufficiency. Spinelli et al. (2017) show that breast cancer cells adapt to ammonia buildup by recycling it for amino acid synthesis, which can support cancer cell growth.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Shan M,Lyssiotis CAdoi
10.1016/j.cmet.2017.11.008subject
Has Abstractpub_date
2017-12-05 00:00:00pages
811-813issue
6eissn
1550-4131issn
1932-7420pii
S1550-4131(17)30676-9journal_volume
26pub_type
评论,杂志文章相关文献
Cell Metabolism文献大全abstract::Global reduction in insulin signaling has been linked to extended life span in a range of organisms. New work on mice with brain-specific or whole-body reductions in insulin receptor substrate 2 (IRS2) (Taguchi et al., 2007) points to a role for insulin/IGF-1 signaling in the central control of mammalian aging. ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2007.08.007
更新日期:2007-09-01 00:00:00
abstract::In mice, interleukin-6 (IL-6) improves glucose tolerance via stimulation of glucagon-like peptide 1 (GLP-1) secretion. In this issue of Cell Metabolism, Lang Lehrskov et al. (2018) demonstrate that IL-6 infusion has GLP-1-dependent and -independent actions with opposing effects on glucose tolerance, resulting in an ov...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2018.05.013
更新日期:2018-06-05 00:00:00
abstract::Obesity-related morbidity and mortality are related to fat accumulation and fat distribution in humans. Two large-scale meta-analyses recently published in Nature by Shungin et al. (2015) and Locke et al. (2015) report novel genetic associations for central and overall obesity; these greatly advance our understanding ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2015.03.016
更新日期:2015-04-07 00:00:00
abstract::Glucose and hormone responsiveness of pancreatic β cells is acquired during postnatal maturation and is critical for appropriate insulin secretion. In a recent issue of Cell Metabolism, Yoshihara et al. (2016) report that estrogen-related receptor γ (ERRγ) promotes functional maturation of both mouse neonatal β cells ...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2016.04.026
更新日期:2016-05-10 00:00:00
abstract::Cyclic AMP (cAMP) and Ca(2+) are key regulators of exocytosis in many cells, including insulin-secreting beta cells. Glucose-stimulated insulin secretion from beta cells is pulsatile and involves oscillations of the cytoplasmic Ca(2+) concentration ([Ca(2+)](i)), but little is known about the detailed kinetics of cAMP...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.06.003
更新日期:2008-07-01 00:00:00
abstract::Mitochondrial dysfunction is a hallmark of multiple metabolic complications. Physical activity is known to increase mitochondrial content in skeletal muscle, counteracting age-related decline in muscle function and protecting against metabolic and cardiovascular complications. Here, we investigated the effect of 4 mon...
journal_title:Cell metabolism
pub_type: 临床试验,杂志文章
doi:10.1016/j.cmet.2016.11.004
更新日期:2017-02-07 00:00:00
abstract::Human brown adipose tissue (BAT) presence, metabolic activity, and estimated mass are typically measured by imaging [18F]fluorodeoxyglucose (FDG) uptake in response to cold exposure in regions of the body expected to contain BAT, using positron emission tomography combined with X-ray computed tomography (FDG-PET/CT). ...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2016.07.014
更新日期:2016-08-09 00:00:00
abstract::The discovery that their neonatal diabetes is caused by gain-of-function mutations in the K(ATP) channel has enabled many patients to switch from insulin to oral sulphonylurea drugs. Here, I review molecular, physiological, and clinical features of this change in therapy. ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2010.02.004
更新日期:2010-03-03 00:00:00
abstract::Genetic conservation allows ancient features of fat storage endocrine pathways to be explored in C. elegans. Multiple studies have used Nile red or BODIPY-labeled fatty acids to identify regulators of fat mass. When mixed with their food, E. coli bacteria, Nile red, and BODIPY-labeled fatty acids stain multiple spheri...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2009.10.002
更新日期:2009-11-01 00:00:00
abstract::Obesity is a heritable disorder, with children of obese fathers at higher risk of developing obesity. Environmental factors epigenetically influence somatic tissues, but the contribution of these factors to the establishment of epigenetic patterns in human gametes is unknown. Here, we hypothesized that weight loss rem...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.11.004
更新日期:2016-02-09 00:00:00
abstract::In the face of the current obesity epidemic, the nature of the relationship between overnutrition and type 2 diabetes is of great importance. Obesity can be considered a state of excessive insulin action that elicits a series of cellular homeostatic responses, producing systemic insulin resistance. These responses occ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2012.03.001
更新日期:2012-06-06 00:00:00
abstract::Type 2 cytokines are important signals triggering biogenesis of thermogenic beige adipocytes in white adipose tissue (WAT) during cold acclimation. However, how cold activates type 2 immunity in WAT remains obscure. Here we show that cold-induced type 2 immune responses and beiging in subcutaneous WAT (scWAT) are abro...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2017.08.003
更新日期:2017-09-05 00:00:00
abstract::The trace element copper (Cu) is a cofactor for biochemical functions ranging from energy generation to iron (Fe) acquisition, angiogenesis, and free radical detoxification. While Cu is essential for life, the molecules that mediate dietary Cu uptake have not been identified. Ctr1 is a homotrimeric protein, conserved ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2006.08.009
更新日期:2006-09-01 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Liver samples from morbidly obese patients (n = 45) with all stages of NAFLD and controls (n = 18) were analyzed by array-based DNA methylation and mRNA expression profiling. NAFLD-specific expression and me...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2013.07.004
更新日期:2013-08-06 00:00:00
abstract::Nuclear receptors (NRs) are key regulators of gene expression and physiology. Nearly half of all human NRs lack endogenous ligands including estrogen-related receptor α (ERRα). ERRα has important roles in cancer, metabolism, and skeletal homeostasis. Affinity chromatography of tissue lipidomes with the ERRα ligand-bin...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.12.010
更新日期:2016-03-08 00:00:00
abstract::Adipocyte mobilization of fatty acids (lipolysis) is instrumental for energy expenditure. Lipolysis displays both spontaneous (basal) and hormone-stimulated activity. It is unknown if lipolysis is important for future body weight gain and associated disturbed glucose metabolism, and this was presently investigated in ...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2018.05.004
更新日期:2018-07-03 00:00:00
abstract::Heme biosynthesis consists of a series of eight enzymatic reactions that originate in mitochondria and continue in the cytosol before returning to mitochondria. Although these core enzymes are well studied, additional mitochondrial transporters and regulatory factors are predicted to be required. To discover such unkn...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2009.06.012
更新日期:2009-08-01 00:00:00
abstract::Altered metabolic function is common in stressed immune cells, but alteration in brain microglia during neurodegeneration is not understood. In this issue, Baik et al. (2019) provide insight into microglial metabolism. They demonstrate a switch from oxidative phosphorylation to glycolysis following interaction with am...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2019.08.017
更新日期:2019-09-03 00:00:00
abstract::The importance of neuropeptides in the hypothalamus has been experimentally established. Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters glutamate and GABA are largely unknown. Synaptic vesicular transporters (VGLUTs for glutamate and VGAT for GABA) are required for ve...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2007.04.001
更新日期:2007-05-01 00:00:00
abstract::The contribution of interleukin (IL)-6 signaling in obesity-induced inflammation remains controversial. To specifically define the role of hepatic IL-6 signaling in insulin action and resistance, we have generated mice with hepatocyte-specific IL-6 receptor (IL-6R) alpha deficiency (IL-6Ralpha(L-KO) mice). These anima...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2010.06.011
更新日期:2010-09-08 00:00:00
abstract::Resveratrol induces mitochondrial biogenesis and protects against metabolic decline, but whether SIRT1 mediates these benefits is the subject of debate. To circumvent the developmental defects of germline SIRT1 knockouts, we have developed an inducible system that permits whole-body deletion of SIRT1 in adult mice. Mi...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2012.04.003
更新日期:2012-05-02 00:00:00
abstract::The biogenesis and function of the mitochondrial respiratory chain (RC) involve the organization of RC enzyme complexes in supercomplexes or respirasomes through an unknown biosynthetic process. This leads to structural interdependences between RC complexes, which are highly relevant from biological and biomedical per...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2012.01.015
更新日期:2012-03-07 00:00:00
abstract::Dietary lipid digestion is critical for body fat storage control, but little is known about the regulation of genes involved in fat breakdown and absorption in the gastrointestinal tract. A Drosophila study (Sieber and Thummel, 2009 [this issue of Cell Metabolism]) now demonstrates that the orphan nuclear receptor DHR...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2009.11.004
更新日期:2009-12-01 00:00:00
abstract::Reduced folate levels can cause developmental defects and megaloblastic anemia. Padmanabhan et al. (2013) show that mutation in mice of a folate metabolism gene, Mtrr, which encodes for methionine synthase reductase, causes developmental defects not only in the mutant progeny, but also in genetically wild-type descend...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2013.09.016
更新日期:2013-10-01 00:00:00
abstract::Pancreatic islet beta cell mass expands in response to certain physiological conditions such as pregnancy and obesity, but the signaling pathways involved are not well understood. Possible insights come from a newly described regulatory circuit through which obesity-enhanced kinase signaling in the liver triggers expa...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.12.009
更新日期:2009-01-07 00:00:00
abstract::While adipogenesis is known to be controlled by a complex network of transcription factors, less is known about the transcriptional cascade that initiates this process. We report here the characterization of Krüppel-like factor 4 (KLF4) as an essential early regulator of adipogenesis. Klf4 is expressed in 3T3-L1 cells...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2008.02.001
更新日期:2008-04-01 00:00:00
abstract::Many of the established positive health benefits of exercise have been documented by historical discoveries in the field of exercise physiology. These investigations often assess limits: the limits of performance, or the limits of exercise-induced health benefits. Indeed, several key findings have been informed by stu...
journal_title:Cell metabolism
pub_type: 杂志文章,评审
doi:10.1016/j.cmet.2017.04.018
更新日期:2017-05-02 00:00:00
abstract::Autophagy is a catabolic process that ensures homeostatic cell clearance and is deregulated in a growing number of myopathological conditions. Although FoxO3 was shown to promote the expression of autophagy-related genes in skeletal muscle, the mechanisms triggering autophagy are unclear. We show that TSC1-deficient m...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2013.03.015
更新日期:2013-05-07 00:00:00
abstract::T cells promote inflammation in obesity, but how metabolic stress associated with obesity alters T cell responses remains unclear. In this issue of Cell Metabolism,Mauro et al. (2017) demonstrate that saturated fatty acids directly increase effector-memory T cell formation by amplifying T cell antigen-receptor-induced...
journal_title:Cell metabolism
pub_type: 评论,杂志文章
doi:10.1016/j.cmet.2017.02.012
更新日期:2017-03-07 00:00:00
abstract::Long non-coding RNAs (lncRNAs) constitute a significant portion of mammalian genome, yet the physiological importance of lncRNAs is largely unknown. Here, we identify a liver-enriched lncRNA in mouse that we term liver-specific triglyceride regulator (lncLSTR). Mice with a liver-specific depletion of lncLSTR exhibit a...
journal_title:Cell metabolism
pub_type: 杂志文章
doi:10.1016/j.cmet.2015.02.004
更新日期:2015-03-03 00:00:00