Abstract：
:The importance of circadian biology has rarely been considered in pre-clinical studies, and even more when translating to the bedside. Circadian biology is becoming a critical factor for improving drug efficacy and diminishing drug toxicity. Indeed, there is emerging evidence showing that some drugs are more effective at nighttime than daytime, whereas for others it is the opposite. This suggests that the biology of the target cell will determine how an organ will respond to a drug at a specific time of the day, thus modulating pharmacodynamics. Thus, it is now time that circadian factors become an integral part of translational research.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Cederroth CR,Albrecht U,Bass J,Brown SA,Dyhrfjeld-Johnsen J,Gachon F,Green CB,Hastings MH,Helfrich-Förster C,Hogenesch JB,Lévi F,Loudon A,Lundkvist GB,Meijer JH,Rosbash M,Takahashi JS,Young M,Canlon Bdoi
10.1016/j.cmet.2019.06.019subject
Has Abstractpub_date
2019-08-06 00:00:00pages
238-250issue
2eissn
1550-4131issn
1932-7420pii
S1550-4131(19)30373-0journal_volume
30pub_type
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