Abstract：
:Adipose tissue in the mammary gland undergoes dramatic remodeling during reproduction. Adipocytes are replaced by mammary alveolar structures during pregnancy and lactation, then reappear upon weaning. The fate of the original adipocytes during lactation and the developmental origin of the re-appearing adipocyte post involution are unclear. Here, we reveal that adipocytes in the mammary gland de-differentiate into Pdgfrα+ preadipocyte- and fibroblast-like cells during pregnancy and remain de-differentiated during lactation. Upon weaning, de-differentiated fibroblasts proliferate and re-differentiate into adipocytes. This cycle occurs over multiple pregnancies. These observations reveal the potential of terminally differentiated adipocytes to undergo repeated cycles of de-differentiation and re-differentiation in a physiological setting.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Wang QA,Song A,Chen W,Schwalie PC,Zhang F,Vishvanath L,Jiang L,Ye R,Shao M,Tao C,Gupta RK,Deplancke B,Scherer PEdoi
10.1016/j.cmet.2018.05.022subject
Has Abstractpub_date
2018-08-07 00:00:00pages
282-288.e3issue
2eissn
1550-4131issn
1932-7420pii
S1550-4131(18)30329-2journal_volume
28pub_type
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