Abstract：
:Injection of the peptide hormone ghrelin stimulates food intake in mice and humans. However, mice born without ghrelin demonstrate no significant loss of appetite. This paradox suggests either that compensation develops in mice born without ghrelin or that ghrelin is not essential for appetite control. To distinguish these possibilities, we generated transgenic mice (Ghrl-DTR) that express the diphtheria toxin receptor in ghrelin-secreting cells. Injection of diphtheria toxin in adulthood ablated ghrelin cells and reduced plasma ghrelin by 80%-95%. Ghrelin cell-ablated mice exhibited no loss of appetite or body weight and no resistance to a high-fat diet. To stimulate food intake in mice by ghrelin injection, we had to raise plasma levels many-fold above normal. Like germline ghrelin-deficient mice, the ghrelin cell-ablated mice developed profound hypoglycemia when subjected to prolonged calorie restriction, confirming that ghrelin acts to maintain blood glucose under famine conditions.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
McFarlane MR,Brown MS,Goldstein JL,Zhao TJdoi
10.1016/j.cmet.2014.04.007subject
Has Abstractpub_date
2014-07-01 00:00:00pages
54-60issue
1eissn
1550-4131issn
1932-7420pii
S1550-4131(14)00171-5journal_volume
20pub_type
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