Microbial determinants of biochemical individuality and their impact on toxicology and pharmacology.

Abstract:

:Humans exhibit remarkable interindividual variations in the concentration of small molecules found throughout the body, due in part to concurrent variations in each person's associated microbial communities. Recent studies have begun to uncover how microbes interface with their host during exposure to drugs, dietary compounds, and environmental toxicants, with broader implications regarding the causes and consequences of biochemical individuality. Progress in this area will likely be an essential component of personalized medicine and might be accelerated through the implementation of experimental designs and theoretical principles honed through decades of work in the fields of toxicology and pharmacology.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Patterson AD,Turnbaugh PJ

doi

10.1016/j.cmet.2014.07.002

subject

Has Abstract

pub_date

2014-11-04 00:00:00

pages

761-768

issue

5

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(14)00310-6

journal_volume

20

pub_type

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