Abstract：
:Exercise leads to changes in muscle phenotype with important implications for exercise performance and health. A recent paper in Cell by Narkar et al. (2008) shows that many of the adaptations in muscle phenotype elicited by exercise can be mimicked by genetic manipulation and drug treatment in mice.
journal_name
Cell Metabjournal_title
Cell metabolismauthors
Richter EA,Kiens B,Wojtaszewski JFdoi
10.1016/j.cmet.2008.07.004subject
Has Abstractpub_date
2008-08-01 00:00:00pages
96-8issue
2eissn
1550-4131issn
1932-7420pii
S1550-4131(08)00211-8journal_volume
8pub_type
杂志文章相关文献
Cell Metabolism文献大全abstract：:While mesenchymal stem cells (MSCs) are rapidly cleared from the body following systemic transplantation, their therapeutic benefits typically persist. In this issue, Liu et al. (2015) reveal that the ability of transplanted MSCs to alleviate osteoporosis in systemic lupus erythematosus is maintained through epigeneti...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2015.09.019
更新日期：2015-10-06 00:00:00
abstract：:C. difficile infection is a deadly disease that is influenced by the microbiome. In a recent article in Nature, Buffie et al. (2014) demonstrate that the ability of C. scindens to synthesize secondary bile acids is crucial to providing resistance to C. difficile infection. ...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2014.12.016
更新日期：2015-01-06 00:00:00
abstract：:Cancer cells frequently hijack normal metabolic pathways to promote their growth and metastasis. Two recent papers by Knott et al. (2018) and Pavlova et al. (2018) demonstrate that asparagine and glutamine work in concert to drive tumor growth and metastasis through modulation of cell survival, growth, and EMT regulat...
journal_title：Cell metabolism
pub_type： 评论
doi：10.1016/j.cmet.2018.04.012
更新日期：2018-05-01 00:00:00
abstract：:Current understanding of microRNA (miRNA) biology is limited, and antisense oligonucleotide (ASO) inhibition of miRNAs is a powerful technique for their functionalization. To uncover the role of the liver-specific miR-122 in the adult liver, we inhibited it in mice with a 2'-O-methoxyethyl phosphorothioate ASO. miR-12...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2006.01.005
更新日期：2006-02-01 00:00:00
abstract：:Circadian clocks regulate most aspects of physiology and metabolism. Genome-wide approaches have uncovered widespread circadian rhythms in the transcriptome, cistrome, and epigenome of mice, and now two proteomics studies in this issue (Robles et al., 2016; Wang et al., 2016) reveal extensive circadian regulation of t...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2016.12.014
更新日期：2017-01-10 00:00:00
abstract：:Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are major phospholipids in mammalian membranes. In liver, PC is synthesized via the choline pathway or by methylation of PE via phosphatidylethanolamine N-methyltransferase (PEMT). Pemt(-/-) mice fed a choline-deficient (CD) diet develop rapid steatohepatitis ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2006.03.007
更新日期：2006-05-01 00:00:00
abstract：:Nutritional and pharmacological stimuli can dramatically alter the cellular phenotypes in white adipose tissue (WAT). Utilizing genetic lineage tracing techniques, we demonstrate that brown adipocytes (BA) that are induced by β3-adrenergic receptor activation in abdominal WAT arise from the proliferation and different...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2012.03.009
更新日期：2012-04-04 00:00:00
abstract：:In mice, interleukin-6 (IL-6) improves glucose tolerance via stimulation of glucagon-like peptide 1 (GLP-1) secretion. In this issue of Cell Metabolism, Lang Lehrskov et al. (2018) demonstrate that IL-6 infusion has GLP-1-dependent and -independent actions with opposing effects on glucose tolerance, resulting in an ov...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2018.05.013
更新日期：2018-06-05 00:00:00
abstract：:High-density lipoproteins (HDLs) can inhibit inflammatory cytokine expression on innate immune cells, but sometimes they promote cytokine production as suggested in a recent article in Cell Metabolism by van der Vorst et al. (2017). Kopecky et al. point out that the origin, handling, and storage conditions of HDL prep...
journal_title：Cell metabolism
pub_type： 信件
doi：10.1016/j.cmet.2017.04.007
更新日期：2017-07-05 00:00:00
abstract：:Accumulating evidence suggests that changes in the metabolic signature of astrocytes underlie their response to neuroinflammation, but how proinflammatory stimuli induce these changes is poorly understood. By monitoring astrocytes following acute cortical injury, we identified a differential and region-specific remode...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2013.11.005
更新日期：2013-12-03 00:00:00
abstract：:Mitochondrial fatty acid oxidation provides an important energy source for cellular metabolism, and decreased mitochondrial fatty acid oxidation has been implicated in the pathogenesis of type 2 diabetes. Paradoxically, mice with an inherited deficiency of the mitochondrial fatty acid oxidation enzyme, very long-chain...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2010.03.012
更新日期：2010-05-05 00:00:00
abstract：:Metabolic reprogramming plays an important role in supporting tumor growth. However, little is known about the metabolic alterations that promote cancer metastasis. In this study, we identify acyl-CoA thioesterase 12 (ACOT12) as a key player in hepatocellular carcinoma (HCC) metastasis. The expression of ACOT12 is sig...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2018.12.019
更新日期：2019-04-02 00:00:00
abstract：:Food intake and activity-induced thermogenesis are important components of energy balance regulation. The molecular mechanism underlying the coordination of food intake with locomotory behavior to maintain energy homeostasis is unclear. We report that the brain-specific homeobox transcription factor Bsx is required fo...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2007.05.007
更新日期：2007-06-01 00:00:00
abstract：:How circulating signals of hunger and satiety enter the brain to reach neurons that govern energy balance has long remained a matter of controversy and speculation. Balland et al. (2014) now elucidate molecular mechanisms by which a highly specialized hypothalamic glial cell regulates transport of leptin across the bl...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2014.01.008
更新日期：2014-02-04 00:00:00
abstract：:The genetic mechanisms mediating longevity and maximum lifespan of the human species are likely different than those explaining differences in life expectancy and healthspan across individuals. Both of these perspectives are important and can be separated and explored using genomic data. ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2016.06.002
更新日期：2016-06-14 00:00:00
abstract：:SIRT1 regulates energy homeostasis by controlling the acetylation status and activity of a number of enzymes and transcriptional regulators. The fact that NAD(+) levels control SIRT1 activity confers a hypothetical basis for the design of new strategies to activate SIRT1 by increasing NAD(+) availability. Here we show...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2011.03.004
更新日期：2011-04-06 00:00:00
abstract：:What are the pathways that underlie the coordinated responses of an organism to well-fed and food-deprived states? A report in this issue of Cell Metabolism suggests that starvation functions via a muscarinic acetylcholine receptor to activate MAP kinase signaling in the pharyngeal muscle of C. elegans (You et al., 20...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2006.03.002
更新日期：2006-04-01 00:00:00
abstract：:AMPK is a kinase involved in cell energy homeostasis. In this issue of Cell Metabolism, Chopra and colleagues (2011) reveal a new function of AMPK in stimulating fat absorption. AMPK enhances the expression of the bile acid transporter, BSEP, by activating the coactivator SRC-2, thus promoting bile acid secretion. ...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2010.12.009
更新日期：2011-01-05 00:00:00
abstract：:Mitochondrial fission is sustained through contact with several organelles, including the endoplasmic reticulum, lysosomes, and the actin cytoskeleton. Nagashima et al. (2020) now demonstrate that PI(4)P-containing Golgi-derived vesicles also modulate mitochondrial fission, driven by Arf1 and PI(4)KIIIβ activity, iden...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2020.05.010
更新日期：2020-06-02 00:00:00
abstract：:The mechanism by which pharmacologic administration of the hormone FGF21 increases energy expenditure to cause weight loss in obese animals is unknown. Here we report that FGF21 acts centrally to exert its effects on energy expenditure and body weight in obese mice. Using tissue-specific knockout mice, we show that βK...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2014.07.012
更新日期：2014-10-07 00:00:00
abstract：:Nitric oxide (NO), generated from L-arginine and oxygen by NO synthases, is a pleiotropic signaling molecule involved in cardiovascular and metabolic regulation. More recently, an alternative pathway for the formation of this free radical has been explored. The inorganic anions nitrate (NO3-) and nitrite (NO2-), origi...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2018.06.007
更新日期：2018-07-03 00:00:00
abstract：:Intestinal sugar sensing has an appetite-stimulating action that enhances preferences for sweets. Han et al. (2016) report that duodenal-jejunal bypass surgery reduces sweet appetite by reducing sugar-induced dopamine release in the dorsal striatum. ...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2015.12.013
更新日期：2016-01-12 00:00:00
abstract：:Cells can enter quiescent states in which cell cycling and growth are suspended. We find that during a long developmental arrest (quiescence) induced by starvation, newly hatched C. elegans acquire features associated with impaired proteostasis and aging: mitochondrial fission, ROS production, protein aggregation, dec...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2016.05.024
更新日期：2016-06-14 00:00:00
abstract：:Leptin signals the repletion of fat stores, acting in the CNS to permit energy utilization by a host of autonomic and neuroendocrine processes and to decrease feeding. While much recent research has focused on the leptin-regulated circuitry of the hypothalamic arcuate nucleus (ARC), the majority of brain leptin recept...
journal_title：Cell metabolism
pub_type： 杂志文章,评审
doi：10.1016/j.cmet.2008.12.001
更新日期：2009-02-01 00:00:00
abstract：:CD4 T cell activation leads to proliferation and differentiation into effector (Teff) or regulatory (Treg) cells that mediate or control immunity. While each subset prefers distinct glycolytic or oxidative metabolic programs in vitro, requirements and mechanisms that control T cell glucose uptake and metabolism in viv...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2014.05.004
更新日期：2014-07-01 00:00:00
abstract：:Elevated levels of tumor necrosis factor (TNFalpha) are implicated in the development of insulin resistance, but the mechanisms mediating these chronic effects are not completely understood. We demonstrate that TNFalpha signaling through TNF receptor (TNFR) 1 suppresses AMPK activity via transcriptional upregulation o...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2006.11.005
更新日期：2006-12-01 00:00:00
abstract：:Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleus (Arc) is critical for the contr...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2013.01.006
更新日期：2013-02-05 00:00:00
abstract：:Oxidative stress causes mitochondrial dysfunction and metabolic complications through unknown mechanisms. Cardiolipin (CL) is a key mitochondrial phospholipid required for oxidative phosphorylation. Oxidative damage to CL from pathological remodeling is implicated in the etiology of mitochondrial dysfunction commonly ...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2010.07.003
更新日期：2010-08-04 00:00:00
abstract：:Type 2 diabetes is an epidemic disease worldwide, but it is difficult to predict its appearance in the general population. A recent study demonstrates that circulating concentrations of a small group of essential amino acids predict risk for diabetes, contributing to a recent resurgence of interest in these common ana...
journal_title：Cell metabolism
pub_type： 评论,杂志文章
doi：10.1016/j.cmet.2011.04.003
更新日期：2011-05-04 00:00:00
abstract：:The Saccharomyces cerevisiae chromatin silencing factor Sir2 suppresses genomic instability and extends replicative life span. In contrast, we find that mouse embryonic fibroblasts (MEFs) deficient for SIRT1, a mammalian Sir2 homolog, have dramatically increased resistance to replicative senescence. Extended replicati...
journal_title：Cell metabolism
pub_type： 杂志文章
doi：10.1016/j.cmet.2005.06.007
更新日期：2005-07-01 00:00:00
