A radical signal activates the epigenetic regulation of longevity.

Abstract:

:Hormesis is an adaptive stress response implicated in longevity regulation. Schroeder et al. (2013) have now connected stress, epigenetic changes, and aging in yeast by showing that mitochondria-derived reactive oxygen species modulate the chromatin binding capacity of the histone demethylase Rph1p at subtelomeres, resulting in lifespan extension.

journal_name

Cell Metab

journal_title

Cell metabolism

authors

Mirisola MG,Longo VD

doi

10.1016/j.cmet.2013.05.015

subject

Has Abstract

pub_date

2013-06-04 00:00:00

pages

812-813

issue

6

eissn

1550-4131

issn

1932-7420

pii

S1550-4131(13)00205-2

journal_volume

17

pub_type

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