Comparison of gadobenate dimeglumine with gadopentetate dimeglumine for magnetic resonance imaging of liver tumors.

Abstract:

RATIONALE AND OBJECTIVES:To compare gadobenate dimeglumine (Gd-BOPTA) with gadopentetate dimeglumine (Gd-DTPA) for magnetic resonance imaging of the liver. METHODS:The contrast agent Gd-BOPTA or Gd-DTPA was administered at a dose of 0.1 mmol/kg to 257 patients suspected of having malignant liver tumors. Dynamic phase images, spin-echo images obtained within 10 minutes of injection, and delayed images obtained 40 to 120 minutes after injection were acquired. All postcontrast images were compared with unenhanced T1-weighted and T2-weighted images obtained immediately before injection. A full safety assessment was performed. RESULTS:The contrast efficacy for dynamic phase imaging was moderately or markedly improved in 90.9% (110/121) and 87.9% (109/124) of patients for Gd-BOPTA and Gd-DTPA, respectively. At 40 to 120 minutes after injection, the cor- responding improvements were 21.7% (26/120) and 11.6% (14/121) for spin-echo sequences and 44.5% (53/119) and 19.0% (23/121) for breath-hold gradient-echo sequences, respectively. The differences at 40 to 120 minutes after injection were statistically significant (P < 0.02). Increased information at 40 to 120 minutes after injection compared with information acquired within 10 minutes of injection was available for 24.0% (29/121) of patients with Gd-BOPTA and for 14.5% (18/124) of patients with Gd-DTPA (P < 0.03). Adverse events were seen in 4.7% (6/128) and 1.6% (2/127) of patients receiving Gd-BOPTA and Gd-DTPA, respectively. The difference was not statistically significant. CONCLUSIONS:The efficacy of Gd-BOPTA is equivalent to that of Gd-DTPA for liver imaging during the dynamic phase and superior during the delayed (40-120 minutes) phase of contrast enhancement. Both agents are safe for use in magnetic resonance imaging of the liver.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Kuwatsuru R,Kadoya M,Ohtomo K,Tanimoto A,Hirohashi S,Murakami T,Tanaka Y,Yoshikawa K,Katayama H

doi

10.1097/00004424-200111000-00002

keywords:

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

632-41

issue

11

eissn

0020-9996

issn

1536-0210

journal_volume

36

pub_type

临床试验,杂志文章,随机对照试验
  • Experimental arterial stent placement. Comparison of a new Nitinol stent and Wallstent.

    abstract:RATIONALE AND OBJECTIVES:To compare technical aspects and neointima formation of a new Nitinol stent and a Wallstent. METHODS:A Nitinol sten and a Wallstent were placed into the iliac arteries of 14 sheep (total of 28 stents) and followed angiographically. Seven sheep were killed after 1 month and 7 after 4.5 months. ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199507000-00004

    authors: Schürmann K,Vorwerk D,Kulisch A,Stroehmer-Kulisch E,Biesterfeld S,Stopinski T,Günther RW

    更新日期:1995-07-01 00:00:00

  • Pulmonary density distribution in experimental noncardiac canine pulmonary edema evaluated by computed transmission tomography.

    abstract::We evaluated the density distribution (anterior-posterior) of the right lung in 19 acutely anesthetized supine dogs using computed transmission tomography (CTT). Eleven dogs served as controls, and eight received 0.12 cc/kg of intravenously administered oleic acid. The latter were sequentially imaged over 1 hour. Nine...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:

    authors: Slutsky RA,Long S,Peck WW,Higgins CB,Mattrey R

    更新日期:1984-05-01 00:00:00

  • Noninvasive quantification of hepatic fat content using three-echo dixon magnetic resonance imaging with correction for T2* relaxation effects.

    abstract:OBJECTIVE:To investigate three-echo T2*-corrected Dixon magnetic resonance imaging (MRI) for noninvasively estimating hepatic fat content (HFC) compared with biopsy. MATERIALS AND METHODS:One hundred patients (50 men, 50 women; mean age, 57.7±14.2 years) underwent clinically indicated liver core biopsy (102 valid tiss...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e31822b124c

    authors: Kühn JP,Evert M,Friedrich N,Kannengiesser S,Mayerle J,Thiel R,Lerch MM,Dombrowski F,Mensel B,Hosten N,Puls R

    更新日期:2011-12-01 00:00:00

  • Developments in X-Ray Contrast Media and the Potential Impact on Computed Tomography.

    abstract::Over the past 120 years, continuous developments in medical imaging has improved diagnosis and treatment for many diseases and has thereby improved treatment outcome and quality of life of many patients. The number of computed tomography (CT) examinations is today increasing by 4% per year worldwide, for a total of ap...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000696

    authors: Schöckel L,Jost G,Seidensticker P,Lengsfeld P,Palkowitsch P,Pietsch H

    更新日期:2020-09-01 00:00:00

  • Interventional atrioseptostomy by application of monopolar high-frequency alternating current. In vitro evaluation of a new device.

    abstract:RATIONALE AND OBJECTIVES:The authors evaluate the use of a new device for interventional creation of atrial septal defects (ASD) working with high-frequency alternating current in an in vitro study with porcine atria. METHODS:The device consists of a symmetrical cage of six superelastic monofile wires, including a mic...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199702000-00003

    authors: Grabitz RG,Handt S,Vanopbroeke HJ,Seghaye MC,Franke A,Osypka P,von Bernuth G

    更新日期:1997-02-01 00:00:00

  • Reduction of Metal Artifacts and Improvement in Dose Efficiency Using Photon-Counting Detector Computed Tomography and Tin Filtration.

    abstract:OBJECTIVES:The aim of this study was to investigate the impact on metal artifacts and dose efficiency of using a tin filter in combination with high-energy threshold (TH) images of a photon-counting detector (PCD) computed tomography (CT) system. MATERIALS AND METHODS:A 3D-printed spine with pedicle screws was scanned...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000535

    authors: Zhou W,Bartlett DJ,Diehn FE,Glazebrook KN,Kotsenas AL,Carter RE,Fletcher JG,McCollough CH,Leng S

    更新日期:2019-04-01 00:00:00

  • Targeted-microbubble binding selectively to GPIIb IIIa receptors of platelet thrombi.

    abstract:RATIONALE AND OBJECTIVES:New targeted microbubbles directed to the GPIIb IIIa receptor have been developed. The objective was to determine whether targeting microbubbles to clots would enhance ultrasound imaging. Systematic studies were designed to determine whether in vitro methodology is an acceptable predictor of in...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200211000-00001

    authors: Schumann PA,Christiansen JP,Quigley RM,McCreery TP,Sweitzer RH,Unger EC,Lindner JR,Matsunaga TO

    更新日期:2002-11-01 00:00:00

  • Hardcopy recording technologies for digitally formatted image data.

    abstract::The hardcopy recording technologies of video cameras, slow-scan (digital spot) recorders, and laser film printers are presented and compared. Slow-scan (digital spot) recorders offer a few advantages when compared with multiformat video cameras. But only laser film printers provide the high-quality hardcopy recordings...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199102000-00017

    authors: Siegel EL,Bishop MD,Wetzel LH,Anderson WF,McMillan JH

    更新日期:1991-02-01 00:00:00

  • Role of red blood cell deformation in toxicity of contrast media in cerebral angiography.

    abstract::The authors investigated the effect on the brain of red blood cells that had been modified by contrast media. Rat blood was mixed with an equivolume of contrast media, and up to 200 microL of the mixture was infused to the internal carotid artery of the rat. Evans blue was administered intravenously to assess the inte...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198905000-00009

    authors: Miyazawa T,Nakagawa H,Oshino N

    更新日期:1989-05-01 00:00:00

  • Contrast gradient and the detection of lung nodules.

    abstract::The effects of edge gradient and blur on the detection pulmonary nodules were studied, using a test series of 175 artificial nodules on 30 chest films. The nodules were of homogeneous texture, about 1 cm in diameter and had a mean contrast of .12. Six observers viewed the film set, scoring both location and confidence...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197901000-00004

    authors: Kundel HL,Revesz G,Toto L

    更新日期:1979-01-01 00:00:00

  • Peripheral magnetic resonance angiography with continuous table movement in combination with high spatial and temporal resolution time-resolved MRA With a total single dose (0.1 mmol/kg) of gadobutrol at 3.0 T.

    abstract:PURPOSE:To prove the concept of peripheral continuous table movement (CTM) MR-angiography (MRA) in combination with high spatial and temporal resolution time-resolved TWIST-MRA in a single MR-examination at 3.0 T with a single dose (0.1 mmol/kg) of gadobutrol in total. MATERIALS AND METHODS:We included 22 consecutive ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3181b4c26c

    authors: Voth M,Haneder S,Huck K,Gutfleisch A,Schönberg SO,Michaely HJ

    更新日期:2009-09-01 00:00:00

  • Biodistribution and excretion of 125I ioversol in conscious dogs.

    abstract::Radiolabeled ioversol was injected intravenously into two male and two female beagle dogs (6.7 to 10.4 kg) at two dose levels each (0.2 and 1.0 g I/kg). Blood levels of radioactivity were monitored at 2, 5, 10, 20, 40, 60, 90, and 120 minutes and at one and two days. Urine and feces were collected in metabolism cages ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198906001-00005

    authors: Coveney JR,Robbins MS

    更新日期:1989-06-01 00:00:00

  • Searching for lung nodules. A comparison of human performance with random and systematic scanning models.

    abstract::The contrast sensitivity of the retina is greatest in the center and decreases rapidly toward the periphery. Therefore, the detection of low-contrast lung nodules depends upon the manner in which the image is sampled by retinal receptors as eye fixations jump across the image during scanning. The scanning performance ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198705000-00010

    authors: Kundel HL,Nodine CF,Thickman D,Toto L

    更新日期:1987-05-01 00:00:00

  • Incompatibility of water-soluble contrast media and intravascular pharmacologic agents. An in vitro study.

    abstract::In vitro incompatibilities between nine water-soluble contrast media and 21 intravascular pharmacologic agents were investigated using naked-eye observation and a centrifuge. Most of the previously reported incompatibilities were verified, and a few new incompatibilities were discovered: phentolamine mesylate with dia...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199201000-00008

    authors: Kim SH,Lee HK,Han MC

    更新日期:1992-01-01 00:00:00

  • Spontaneous acute dissection of the internal carotid artery: high-resolution magnetic resonance imaging at 3.0 tesla with a dedicated surface coil.

    abstract:PURPOSE:Magnetic Resonance Imaging (MRI) has become the method of choice in the evaluation of patients with suspected cervical artery dissection (CAD). However, reliable identification of acute CAD might be impaired by the limited spatial resolution of standard 1.5 T MRI. In this preliminary study, we implemented a mul...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000195836.57778.1f

    authors: Bachmann R,Nassenstein I,Kooijman H,Dittrich R,Kugel H,Niederstadt T,Kuhlenbäumer G,Ringelstein EB,Krämer S,Heindel W

    更新日期:2006-02-01 00:00:00

  • Acquired cystic disease of the kidneys. Computed tomography and ultrasonography appraisal in patients on peritoneal and hemodialysis.

    abstract::Screening chronic hemodialysis patients (CHD) for acquired cystic disease of the kidneys (ACDK) and its complications (hemorrhage and neoplasm) has become accepted management. We evaluated patients on CHD as well as patients on chronic peritoneal dialysis (CPD) for ACDK. The kidneys of 80 chronic dialysis patients wer...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:

    authors: Jabour BA,Ralls PW,Tang WW,Boswell WD Jr,Colletti PM,Feinstein EI,Massry SG

    更新日期:1987-09-01 00:00:00

  • Detection of pulmonary nodules with move-during-scan magnetic resonance imaging using a free-breathing turbo inversion recovery magnitude sequence.

    abstract:PURPOSE:Detection of pulmonary metastases is still a challenging task for magnetic resonance imaging (MRI). It was the aim of this study to evaluate the potential of a free-breathing move-during-scan turbo inversion recovery magnitude sequence for the detection of pulmonary nodules. MATERIALS AND METHODS:The sensitivi...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e31816901fa

    authors: Baumann T,Ludwig U,Pache G,Gall C,Saueressig U,Fisch D,Stankovic Z,Bartholomae JP,Honal M,Bley TA,Langer M,Schaefer O

    更新日期:2008-06-01 00:00:00

  • The effect of radiographic contrast media on leukocyte motility.

    abstract:RATIONALE AND OBJECTIVES:Studies describing the effects of radiographic contrast media (RCM) in leukocyte chemotaxis have been contradictory. No studies have been performed after in-vivo exposure. The authors assess the effect of RCM on leukocytes following in-vivo exposure. METHODS:Seventeen patients were studied aft...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199401000-00012

    authors: Roobottom CA,Farrow R,Wells IP,Hurlock-Fimls N

    更新日期:1994-01-01 00:00:00

  • Arterial blood flow measurement: assessment of velocity estimation methods.

    abstract::Three methods are presented which provide statistically acceptable estimates of mean transit time of opacified blood during angiography. While the methods vary in precision, the selection of the method appropriate for any particular experimental model depends on the degree of precision required to demonstrate the effe...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197707000-00004

    authors: Silverman NR,Rosen L

    更新日期:1977-07-01 00:00:00

  • Temporal changes in the oxidation state in in vitro blood.

    abstract::The rates at which the paramagnetic compounds deoxyhemoglobin (Hb) and methemoglobin (MHb) form in vivo within an area of hemorrhage are unknown. The present experiment establishes the baseline concentrations and rates of change in paramagnetic hemoglobin concentrations, as well as the pH in normal heparinized and clo...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199003000-00006

    authors: Taber KH,Migliore PJ,Pagani JJ,Ford JJ,McLauren T,Hayman LA

    更新日期:1990-03-01 00:00:00

  • Analysis of radiocontrast-induced nephropathy by dual-labeled radionuclide clearance.

    abstract:RATIONALE AND OBJECTIVES:This study was devised to develop a method of measuring the acute effects of radiocontrast media on renal function and assessing the relationship of the dose of radiocontrast media infused with the incidence of radiocontrast-induced renal failure. In addition, the drug adenosine phosphate-magne...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004424-199406000-00004

    authors: Albert SG,Shapiro MJ,Brown WW,Goodgold H,Zuckerman D,Durham R,Kern M,Fletcher J,Wolverson M,Plummer ES

    更新日期:1994-06-01 00:00:00

  • Relative carotid blood flow measurements in dogs by high-speed CT. A preliminary study.

    abstract::A high-speed computed tomography (CT) scanner was used for measuring flow in a phantom and in the common carotid arteries of six dogs. The general ability of the scanner to assess flow using contrast media boluses was tested with the phantom. The validated simple concept was then used in the animals. The carotid blood...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198712000-00008

    authors: Ringertz HG,Jaschke W,Sievers R,Lipton MJ

    更新日期:1987-12-01 00:00:00

  • Intracranial arteriovenous malformations. Current imaging and treatment.

    abstract::Patients with intracranial arteriovenous malformations (AVM) can expect significant mortality (15% to 20%) and morbidity (20% to 30%) over a 15-year to 20-year period. Recent advances in interventional neuroradiology, neurosurgery, neuroanesthesia, and stereotactic radiotherapy provide the opportunity to obliterate ma...

    journal_title:Investigative radiology

    pub_type: 杂志文章,评审

    doi:10.1097/00004424-199008000-00014

    authors: Graves VB,Duff TA

    更新日期:1990-08-01 00:00:00

  • Applications of voxel shifting in magnetic resonance imaging.

    abstract::Due to the nature of three-dimensional Fourier transform (3-DFT) data acquisition in magnetic resonance imaging (MRI), the spatial relation between a resolved volume element (a voxel) and the object can be manipulated easily. Those manipulations have practical consequences in terms of registering slice positions with ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199012000-00006

    authors: Kramer D,Li A,Simovsky I,Hawryszko C,Hale J,Kaufman L

    更新日期:1990-12-01 00:00:00

  • T2-Weighted 4D Magnetic Resonance Imaging for Application in Magnetic Resonance-Guided Radiotherapy Treatment Planning.

    abstract:OBJECTIVES:The aim of this study was to develop and verify a method to obtain good temporal resolution T2-weighted 4-dimensional (4D-T2w) magnetic resonance imaging (MRI) by using motion information from T1-weighted 4D (4D-T1w) MRI, to support treatment planning in MR-guided radiotherapy. MATERIALS AND METHODS:Ten pat...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000381

    authors: Freedman JN,Collins DJ,Bainbridge H,Rank CM,Nill S,Kachelrieß M,Oelfke U,Leach MO,Wetscherek A

    更新日期:2017-10-01 00:00:00

  • Assessment and reproducibility of aortic atherosclerosis magnetic resonance imaging: impact of 3-Tesla field strength and parallel imaging.

    abstract:OBJECTIVES:To investigate image quality and interstudy reproducibility of aortic atherosclerosis imaging at 1.5 T, and to explore the impact of parallel imaging techniques at 3 T. MATERIALS AND METHODS:Institutional review board approval and informed consent were obtained. Thirty-two subjects (20 normal, 12 patients w...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e318181538a

    authors: Maroules CD,McColl R,Khera A,Peshock RM

    更新日期:2008-09-01 00:00:00

  • The uptake of manganese dipyridoxal-diphosphate by chemically induced hepatocellular carcinoma in rats. A correlation between contrast-media-enhanced magnetic resonance imaging, tumor differentiation, and vascularization.

    abstract:OBJECTIVES AND RATIONALE:Negative enhancement of implanted liver tumors has been achieved in preclinical studies on manganese dipyridoxal-diphosphate (Mn-DPDP), a new hepatobiliary specific contrast agent for magnetic resonance imaging (MRI). The authors investigated the effects of Mn-DPDP on primary liver cancer and i...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199306000-00011

    authors: Ni Y,Marchal G,Zhang X,Van Hecke P,Michiels J,Yu J,Rummeny E,Lodemann KP,Baert AL

    更新日期:1993-06-01 00:00:00

  • Evaluation of complex joint motion with computer-based analysis of fluoroscopic sequences.

    abstract:RATIONALE AND OBJECTIVES:To develop a computer-assisted analysis of complex joint motion based on standard fluoroscopic sequences. MATERIALS AND METHODS:Fluoroscopic sequences of 10 normal shoulders and 20 patients after total shoulder arthroplasty were recorded during abduction and adduction. The analysis of the shou...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200202000-00004

    authors: Pfirrmann CW,Huser M,Székely G,Hodler J,Gerber C

    更新日期:2002-02-01 00:00:00

  • Evaluation of normal prostate tissue, chronic prostatitis, and prostate cancer by quantitative perfusion analysis using a dynamic contrast-enhanced inversion-prepared dual-contrast gradient echo sequence.

    abstract:OBJECTIVE:To quantify independent pharmacokinetic parameters for differentiation of prostate pathology. MATERIAL AND METHODS:Twenty-seven patients with biopsy-proven prostate cancer (PSA: 1.4-16.1 ng/mL) underwent magnetic resonance imaging with a new dynamic contrast-enhanced, inversion-prepared dual-contrast gradien...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e31816b2f63

    authors: Franiel T,Lüdemann L,Rudolph B,Rehbein H,Staack A,Taupitz M,Prochnow D,Beyersdorff D

    更新日期:2008-07-01 00:00:00

  • Intravascular ultrasound imaging of vascular responsiveness in isolated perfused canine arteries.

    abstract::We investigated the feasibility of using intravascular ultrasound imaging to analyze vascular physiology in various arterial beds. Canine superficial femoral, external iliac, and common carotid arteries were harvested and suspended and perfused in a bath of oxygenated, heated, physiologic salt solution. A 6-Fr, 20-MHz...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199103000-00010

    authors: Wilson MW,Webb RC,Marx MV,Meyer CR,Gallagher MA,Haarer SL,Buda AJ,Williams DM

    更新日期:1991-03-01 00:00:00