Analysis of radiocontrast-induced nephropathy by dual-labeled radionuclide clearance.

Abstract:

RATIONALE AND OBJECTIVES:This study was devised to develop a method of measuring the acute effects of radiocontrast media on renal function and assessing the relationship of the dose of radiocontrast media infused with the incidence of radiocontrast-induced renal failure. In addition, the drug adenosine phosphate-magnesium chloride (ATP-MgCl2) was evaluated as a renoprotective agent. METHODS:Eighteen patients with pre-existing renal impairment, (serum creatinine greater than 133 mumol/L) were randomized to receive a continuous infusion of ATP-MgCl2 or placebo before and during a radiocontrast procedure. Subjects were monitored with daily serum creatinine and with radionuclide renal clearance studies at baseline, during, and 24 hours after the radiocontrast procedure. RESULTS:There was an initial deterioration in renal clearance in the entire study group (from 44.2 +/- 4.6 to 32.6 +/- 3.9 mL/min, P = .001) which was independent of the dose of radiocontrast infused. There was a persistent deterioration in renal clearance only in those who received greater than 135 mL of contrast media (from 48.6 +/- 7.8 to 37.1 +/- 3.9 mL/min, P = .05). There also was an increase in serum creatinine that persisted only in those subjects who received greater than 135 mL of contrast media (230 +/- 27 to 283 +/- 44 mumol/L, P = .01). CONCLUSION:Persistent deterioration in renal function after radiocontrast administration appears to be dose-dependent and is not prevented by the use of ATP-MgCl2. Radionuclide techniques are useful in monitoring acute changes in renal function during radiocontrast procedures and may be of value in assessing renal impairment in future intervention studies.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Albert SG,Shapiro MJ,Brown WW,Goodgold H,Zuckerman D,Durham R,Kern M,Fletcher J,Wolverson M,Plummer ES

doi

10.1097/00004424-199406000-00004

subject

Has Abstract,Author List Incomplete

pub_date

1994-06-01 00:00:00

pages

618-23

issue

6

eissn

0020-9996

issn

1536-0210

journal_volume

29

pub_type

临床试验,杂志文章,随机对照试验
  • A preliminary study of MRI quantification of simulated calcified pulmonary nodules.

    abstract::The potential of magnetic resonance imaging (MRI) quantification of calcium for the evaluation of pulmonary nodules was investigated in simulated nodules. Calcium salts do not contain mobile protons and thus have no signal on MR proton images. To determine whether the absence of signal from partially calcified nodules...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198711000-00001

    authors: Gamsu G,de Geer G,Cann C,Müller N,Brito A

    更新日期:1987-11-01 00:00:00

  • Gadobutrol-enhanced, three-dimensional, dynamic MR imaging with MR cholangiography for the preoperative evaluation of bile duct cancer.

    abstract:PURPOSE:To evaluate the diagnostic performance of 1.0-M gadobutrol-enhanced, 3-dimensional (3D), dynamic MR images with 3D-MR cholangiography (MRC) in the preoperative evaluation of bile duct cancer staging and resectability. MATERIALS AND METHODS:Our institutional review board approved this retrospective study. Sixty...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3181d2eeb1

    authors: Ryoo I,Lee JM,Chung YE,Park HS,Kim SH,Han JK,Choi BI

    更新日期:2010-04-01 00:00:00

  • Magnetization Transfer Imaging Predicts Porcine Kidney Recovery After Revascularization of Renal Artery Stenosis.

    abstract:MATERIALS AND METHODS:Stenotic kidney (STK) and contralateral kidney magnetization transfer ratios (MTRs; Mt/M0) were measured at 3.0-T magnetic resonance imaging, at offset frequencies of 600 and 1000 Hz, before and 1 month post-PTRA in 7 RVD pigs. Stenotic kidney MTR was correlated to renal perfusion, renal blood flo...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000711

    authors: Afarideh M,Jiang K,Ferguson CM,Woollard JR,Glockner JF,Lerman LO

    更新日期:2021-02-01 00:00:00

  • Pharmacologic treatment of intimal hyperplasia after metallic stent placement in the peripheral arteries. An experimental study.

    abstract:RATIONALE AND OBJECTIVES:To evaluate the efficacy of oral administration of cilostazol, an antithrombotic agent, for the prevention of thrombotic occlusion and intimal hyperplasia after stenting. METHODS:Single-bodied Z-stents were placed in the iliac arteries of 23 dogs. Before stenting, an embolizing coil was introd...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199509000-00004

    authors: Kubota Y,Kichikawa K,Uchida H,Maeda M,Nishimine K,Makutani S,Sakaguchi S,Yoshioka T,Ohishi H,Kimura Y

    更新日期:1995-09-01 00:00:00

  • Ultrasound Time-Harmonic Elastography of the Pancreas: Reference Values and Clinical Feasibility.

    abstract:OBJECTIVES:Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumor with a very low 5-year survival rate of 8%. The aims of this study are to determine reference values and physiologic confounders in healthy pancreas and to assess the diagnostic accuracy of ultrasound time-harmonic elastography (THE) in the d...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000638

    authors: Burkhardt C,Tzschätzsch H,Schmuck R,Bahra M,Jürgensen C,Pelzer U,Hamm B,Braun J,Sack I,Marticorena Garcia SR

    更新日期:2020-05-01 00:00:00

  • An experimental evaluation of central vs. peripheral injection for intravenous digital subtraction angiography (IV-DSA).

    abstract::At a given radiation dosage and field of view, five variables are under meaningful control for intravenous digital subtraction angiography (IV-DSA): concentration and quantity of contrast media injected, volume of injectate, rate of injection, and site of injection. Some controversy exists regarding the selection of a...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198401000-00007

    authors: Rubin DL,Burbank FH,Bradley BR,Brody WR

    更新日期:1984-01-01 00:00:00

  • Magnetic resonance imaging-guided percutaneous biopsy of mediastinal masses: diagnostic performance and safety.

    abstract:OBJECTIVE:The objective of this study was to evaluate the diagnostic performance and safety of magnetic resonance (MR) imaging-guided percutaneous mediastinal biopsy procedures using a 0.23-T open MR system with optical tracking navigation. MATERIALS AND METHODS:A retrospective analysis of 59 participants (38 males an...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章

    doi:10.1097/RLI.0b013e31827a4a17

    authors: Lü Y,Fritz J,Li C,Liu M,Lee P,Wu L,Carrino JA

    更新日期:2013-06-01 00:00:00

  • A revised estimate of the risk of carcinogenesis from x-rays to scoliosis patients.

    abstract::A considerable amount of concern has been felt recently for the risk of carcinogenesis from x-rays to scoliosis patients. This paper re-evaluates risk in quantitative terms by using some data measured by us and other data recently published in the literature. The risks are considerably smaller than had been estimated ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198401000-00014

    authors: Rao PS,Gregg EC

    更新日期:1984-01-01 00:00:00

  • Consistency of rotator-cuff calcifications. Observations on plain radiography, sonography, computed tomography, and at needle treatment.

    abstract:RATIONALE AND OBJECTIVES:The author analyzes findings of consistency of rotator-cuff calcifications found at ultrasound (US)-guided needle treatment compared with findings of plain radiography, US, and computed tomography (CT). METHODS:Twenty patients had rotator-cuff calcifications (mean diameter, 1.5 cm; range, 1.1-...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199605000-00010

    authors: Farin PU

    更新日期:1996-05-01 00:00:00

  • Ventral sacroiliac ligament. Anatomic and pathologic considerations.

    abstract:RATIONALE AND OBJECTIVES:The ventral sacroiliac ligament (VSL), which bridges the sacroiliac (SI) joint anteriorly, has been described as an important stabilizing structure of the joint, but no data exist regarding its assessment with routine and advanced imaging methods. The authors determine the imaging appearance of...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199608000-00009

    authors: Jaovisidha S,Ryu KN,De Maeseneer M,Haghighi P,Goodwin D,Sartoris DJ,Resnick D

    更新日期:1996-08-01 00:00:00

  • Impact of Impaired Renal Function on Gadolinium Retention After Administration of Gadolinium-Based Contrast Agents in a Mouse Model.

    abstract:OBJECTIVES:The aim of this study was to investigate the impact of impaired renal function on gadolinium (Gd) retention in various organs after Gd-based contrast agent injection. MATERIALS AND METHODS:After local animal care and review committee approval, 23 normal mice and 26 with renal failure were divided into 4 tre...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000295

    authors: Kartamihardja AA,Nakajima T,Kameo S,Koyama H,Tsushima Y

    更新日期:2016-10-01 00:00:00

  • Phase I clinical evaluation of citrate-coated monocrystalline very small superparamagnetic iron oxide particles as a new contrast medium for magnetic resonance imaging.

    abstract:RATIONALE AND OBJECTIVES:To evaluate the safety and pharmacokinetics of a newly developed MR contrast medium consisting of very small superparamagnetic iron oxide particles (VSOP) coated with citrate (VSOP-C184) in a clinical phase I trial. METHODS:A total of 18 healthy subjects received either VSOP-C184 (core diamete...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.rli.0000129472.45832.b0

    authors: Taupitz M,Wagner S,Schnorr J,Kravec I,Pilgrimm H,Bergmann-Fritsch H,Hamm B

    更新日期:2004-07-01 00:00:00

  • Brain tumor enhancement in magnetic resonance imaging: dependency on the level of protein binding of applied contrast agents.

    abstract:PURPOSE:To evaluate the dependency of tumor contrast enhancement (CE) in regard to protein-binding properties of contrast agents, using 4 different agents with a wide range of protein-binding capacities in a standardized rat brain glioma model. MATERIAL AND METHODS:Sixteen rats with implanted brain gliomas were evalua...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e318191a334

    authors: Wintersperger BJ,Runge VM,Tweedle MF,Jackson CB,Reiser MF

    更新日期:2009-02-01 00:00:00

  • Characterization of radial forces in Z stents.

    abstract:RATIONAL AND OBJECTIVES:The purpose of this study was to evaluate the effects of variation in design parameters on the resultant radial force. We evaluated the influence of wire gauge, leg length, and number of bends on the radial force produced by z stents and compared these with radial forces produced by commercial s...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200109000-00004

    authors: Snowhill PB,Nosher JL,Siegel RL,Silver FH

    更新日期:2001-09-01 00:00:00

  • Detection of emphysema with computed tomography. Correlation with pulmonary function tests and chest radiography.

    abstract::We studied 60 male patients who had concurrent chest films (CXR), computed tomography scans (CT) and pulmonary function tests (PFT) to assess the sensitivity of CT and conventional films in detecting emphysema compared with PFT. We also sought to determine whether emphysema could be diagnosed by CT in patients with no...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198804000-00004

    authors: Sanders C,Nath PH,Bailey WC

    更新日期:1988-04-01 00:00:00

  • Initial evaluation of non-contrast-enhanced magnetic resonance angiography in patients with peripheral arterial occlusive disease at 7 T.

    abstract:OBJECTIVES:The aim of this study was to achieve initial experience with non-contrast-enhanced (ne) magnetic resonance angiography (MRA) of the lower leg arteries in patients with peripheral arterial occlusive disease (PAOD) at 7 T. MATERIALS AND METHODS:Seven patients with PAOD were examined on a 7-T whole-body magnet...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000044

    authors: Fischer A,Maderwald S,Johst S,Orzada S,Ladd ME,Umutlu L,Lauenstein TC,Kniemeyer HW,Nassenstein K

    更新日期:2014-05-01 00:00:00

  • Searching for lung nodules. A comparison of human performance with random and systematic scanning models.

    abstract::The contrast sensitivity of the retina is greatest in the center and decreases rapidly toward the periphery. Therefore, the detection of low-contrast lung nodules depends upon the manner in which the image is sampled by retinal receptors as eye fixations jump across the image during scanning. The scanning performance ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198705000-00010

    authors: Kundel HL,Nodine CF,Thickman D,Toto L

    更新日期:1987-05-01 00:00:00

  • Ultrasonic echoes registered from erythrocytes.

    abstract::Erythrocytes at various concentrations were examined with a sensitive A-mode ultrasonic scanner; simultaneous measurements were made under light microscopic control. Individual erythrocytes caused weak (about 1 dB) echoes while erythrocyte aggregates (ten to 100 cells) produced stronger echoes (up to 15 dB), grossly p...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198508000-00014

    authors: Alanen A,Kormano M

    更新日期:1985-08-01 00:00:00

  • Can Ferumoxytol be Used as a Contrast Agent to Differentiate Between Acute and Chronic Inflammatory Kidney Disease?: Feasibility Study in a Rat Model.

    abstract:OBJECTIVES:Ferumoxytol, an intravenous iron supplement, can be used in off-label mode as a contrast agent in magnetic resonance imaging. The aim of this study was to assess whether ferumoxytol can be used as a marker of inflammation in animal models of acute and chronic inflammatory kidney diseases. MATERIAL AND METHO...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000209

    authors: Budjan J,Neudecker S,Schock-Kusch D,Kraenzlin B,Schoenberg SO,Michaely HJ,Attenberger UI

    更新日期:2016-02-01 00:00:00

  • The pediatric tracheostomy: III). An appraisal of xerography.

    abstract::Comparatively new in the roentgen evaluation of infants and children, xerography would appear to be ideal for portraying the pediatric airway. Since the radiation dose of xerography is higher than conventional radiography, its image quality is the subject of careful scrutiny in a pediatric setting here described in 23...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197807000-00002

    authors: Scott JR,Kramer SS,Griscom NT

    更新日期:1978-07-01 00:00:00

  • Necrotic areas in VX2 carcinoma of rabbits. Correlation of magnetic resonance imaging and pathologic appearance.

    abstract:RATIONALE AND OBJECTIVES:To assess the potential of magnetic resonance imaging (MRI) for evaluating the evolution of tumor necrosis, the authors evaluated 28 VX2 carcinomas inoculated in the thigh muscles of rabbits. METHODS:MRI of VX2 carcinomas at 2.0 T was done with spin-echo technique 1 week (14 tumors) and 3 week...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199301000-00010

    authors: Choi BI,Lee DH,Han MC

    更新日期:1993-01-01 00:00:00

  • Potential of dose reduction after marker placement with full-field digital mammography.

    abstract:OBJECTIVES:The purpose of our study was to assess the potential for radiation dose reduction in digital postinterventional digital mammograms after marker placement. MATERIALS AND METHODS:One hundred consecutive cases of marker placement (hook-wire localization or postbiopsy clip marker placement), with 200 full-field...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000163743.63063.9f

    authors: Riedl CC,Jaromi S,Floery D,Pfarl G,Fuchsjaeger MH,Helbich TH

    更新日期:2005-06-01 00:00:00

  • Effect of transcatheter hepatic arterial embolization on angiogenesis in an animal model.

    abstract:OBJECTIVES:Transcatheter arterial embolization (TAE) is used for the treatment of patients with malignant liver tumors. However, the proangiogenesis effect of TAE-associated hypoxia has not been adequately studied. The goal of this study was to determine angiogenic activity in tumors subjected to TAE by evaluating the ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000209663.00629.8a

    authors: Gupta S,Kobayashi S,Phongkitkarun S,Broemeling LD,Kan Z

    更新日期:2006-06-01 00:00:00

  • Alteration of human tumor cell adhesion by high-strength static magnetic fields.

    abstract:RATIONALE AND OBJECTIVES:The authors investigated whether the ability of human malignant melanoma cells to increase in cell number or their ability to remain viable was compromised by high-field strength static magnetic fields. Normal human fibroblasts also were studied to determine if any magnetic field-related altera...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199210000-00014

    authors: Short WO,Goodwill L,Taylor CW,Job C,Arthur ME,Cress AE

    更新日期:1992-10-01 00:00:00

  • A new animal model for testing renal tolerance of contrast agents.

    abstract:RATIONALE AND OBJECTIVES:To develop a new animal model for the evaluation of the renal tolerance of contrast agent and its application to diatrizoate and iotrolan injections in comparison to saline and mannitol solution. MATERIALS AND METHODS:The nephrotoxic potential of intravenously injected contrast agents in Beagl...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000087096.61127.13

    authors: Krause W,Gilles T

    更新日期:2003-11-01 00:00:00

  • Response of tumors to therapy studied by 31P magnetic resonance spectroscopy.

    abstract::Magnetic resonance (MR) methods have been used to study the metabolic and vascular response of model tumors to tumor necrosis factor (TNF). Magnetic resonance measurements demonstrated acute reductions in tumor blood flow, measured from tumor uptake of D2O, and in tumor adenosine triphosphate (ATP), measured by 31P ma...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198912000-00022

    authors: Karczmar GS,Meyerhoff DJ,Speder A,Valone F,Wilkinson M,Shine N,Boska MD,Weiner MW

    更新日期:1989-12-01 00:00:00

  • Collateral arterial formation. Lymph draining ischemic kidneys contains a neovascular stimulating agent of high molecular weight.

    abstract::An agent has been identified in lymph from rat kidneys rendered ischemic by partial renal artery occlusion that induces a striking neovascular response in a hamster cheek-pouch assay system. The factor has a high molecular weight, cannot be identified in lymph from normal kidneys, and is associated with a marked incre...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198501000-00015

    authors: Hollenberg NK,Paskins-Hurlburt AJ,Abrams HL

    更新日期:1985-01-01 00:00:00

  • Assessment of large bowel motility by cine magnetic resonance imaging using two different prokinetic agents: a feasibility study.

    abstract:OBJECTIVES:We sought to assess large bowel motility, induced by 2 prokinetic agents, senna tea and erythromycin, using functional cine magnetic resonance imaging (MRI). MATERIALS AND METHODS:Twelve volunteers underwent functional cine MRI before and after the administration of senna tea or erythromycin. The protocol c...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000183054.43131.a8

    authors: Buhmann S,Kirchhoff C,Wielage C,Mussack T,Reiser MF,Lienemann A

    更新日期:2005-11-01 00:00:00

  • 3 T contrast-enhanced magnetic resonance angiography for evaluation of the intracranial arteries: comparison with time-of-flight magnetic resonance angiography and multislice computed tomography angiography.

    abstract:PURPOSE:We sought to prospectively evaluate the image quality and visualization of the intracranial arteries using high spatial resolution contrast-enhanced magnetic resonance angiography (CE-MRA) at 3 T and to perform intraindividual comparison with time-of-flight (TOF) MRA and multislice CT angiography (CTA). MATERI...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.rli.0000242835.00032.f5

    authors: Villablanca JP,Nael K,Habibi R,Nael A,Laub G,Finn JP

    更新日期:2006-11-01 00:00:00

  • Diffusivity- and T2 imaging at 3 Tesla for the detection of degenerative changes in human-excised tissue with high resolution: atherosclerotic arteries.

    abstract:RATIONALE AND OBJECTIVES:We investigated whether it is possible to investigate degenerative changes in human tissue on a sub-100-microm resolution scale not only on special high-field small-bore MR-microscopy systems but also on a 3T whole-body MR-scanner. METHODS:Spin-spin relaxation, proton density, and diffusion mi...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.RLI.0000068620.17569.83

    authors: Berg A,Sailer J,Rand T,Moser E

    更新日期:2003-07-01 00:00:00