Abstract:
RATIONALE AND OBJECTIVES:To develop a new animal model for the evaluation of the renal tolerance of contrast agent and its application to diatrizoate and iotrolan injections in comparison to saline and mannitol solution. MATERIALS AND METHODS:The nephrotoxic potential of intravenously injected contrast agents in Beagle dogs was determined from the effects on the pharmacokinetics of creatinine injected immediately after these agents in comparison with the kinetics of creatinine injected alone. The kinetic parameters evaluated included plasma half-life, volume of distribution, and clearance. In a series of studies, the experimental conditions were optimized in terms of creatinine dose and the effects of diatrizoate, iotrolan, saline, and mannitol solution on the pharmacokinetic parameters of creatinine were determined. RESULTS:Bolus injection of creatinine into dogs followed a dose-linear pharmacokinetic behavior with a terminal half-life of 90 minutes (10 mg/kg) and 108 minutes (20 mg/kg), respectively, and a clearance of 5 mL/min/kg. Injection of diatrizoate decreased the clearance and the half-life of creatinine significantly. A mannitol solution with the same osmolality as diatrizoate showed the same effect whereas physiological saline did not affect pharmacokinetic parameters of creatinine. The isotonic iotrolan was intermediate between saline and diatrizoate in its effects on creatinine clearance. CONCLUSION:The effect of contrast agents on pharmacokinetic parameters of creatinine injected immediately after the administration of the agents in dogs might be a useful model for the evaluation of renal tolerance. In a cross-over study, iotrolan was not statistically separable from diatrizoate.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Krause W,Gilles Tdoi
10.1097/01.rli.0000087096.61127.13keywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
704-11issue
11eissn
0020-9996issn
1536-0210journal_volume
38pub_type
杂志文章abstract::Radiation dose in computed tomography (CT) has become a hot topic due to an upward trend in the number of CT procedures worldwide and the relatively high doses associated with these procedures. The main aim of this review article is to provide an overview of the most frequently used metrics for CT radiation dose chara...
journal_title:Investigative radiology
pub_type: 杂志文章
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journal_title:Investigative radiology
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journal_title:Investigative radiology
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journal_title:Investigative radiology
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doi:10.1097/00004424-198501000-00015
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journal_title:Investigative radiology
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doi:10.1097/00004424-199210000-00001
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199202000-00016
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doi:10.1097/00004424-199110000-00009
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journal_title:Investigative radiology
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更新日期:2010-04-01 00:00:00
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更新日期:2019-08-01 00:00:00
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journal_title:Investigative radiology
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doi:10.1097/00004424-200007000-00001
更新日期:2000-07-01 00:00:00
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doi:
更新日期:1984-05-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198807000-00007
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