Abstract:
OBJECTIVE:To investigate the correlation between intravoxel incoherent motion (IVIM) model-derived parameters and histologically determined microvascularity in pancreatic ductal adenocarcinomas (PDACs) and pancreatic neuroendocrine tumors (PNETs). MATERIALS AND METHODS:From April 2013 to May 2014, 42 patients with malignant pancreatic tumors were prospectively examined with diffusion-weighted imaging (DWI) magnetic resonance imaging using a breath-hold variant with 9 b values (0-800 seconds/mm). Intravoxel incoherent motion parameters were extracted from 2 types of volumes of interest (VOIs), one VOI encompassing the total tumor volume (TTV) and another VOI corresponding to the histological regional tumor location (RTV). In 36 PDACs and 6 PNETs, microvessel analysis was performed based on representative tissue sections from the resected tumor tissue, and microvessel density (MVD) as well as microvessel area were calculated. We performed a Pearson-correlation test to study the relationship between IVIM-derived and histology-derived parameters. RESULTS:The DWI-IVIM-derived flowing blood volume fraction f was significantly lower in PDACs compared to PNETs (9.9% ± 5.4% vs 15.5% ± 5.2%; P < 0.0001), the diffusion coefficient D was significantly higher (1.2 ± 0.18 × 10 vs 1.03 ± 0.15 × 10 mm/s; P = 0.001). There was no significant difference in the pseudodiffusion coefficient D* (44.9 ± 52.9 ×10 vs 53.8 ± 51.2 × 10 mm/s). Microvessel density was significantly lower in PDACs (36.8 ± 25.9/mm vs 80.0 ± 26.1/mm; P = 0.0005) compared to PNETs. When derived from the RTV, the flowing blood volume fraction f and MVD of PDACs and PNETs showed excellent correlation (r = 0.85). The correlation using the TTV was moderate (0.64). f (RTV and TTV) and microvessel area showed moderate correlation (r = 0.54/0.47). CONCLUSIONS:Intravoxel incoherent motion-derived flowing blood volume fraction f and MVD demonstrate an excellent correlation with histological tumor features in PDAC and PNET. Consequently, IVIM DWI may serve as noninvasive marker of tumor vascularity in different types of pancreatic neoplasms.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Klau M,Mayer P,Bergmann F,Maier-Hein K,Hase J,Hackert T,Kauczor HU,Grenacher L,Stieltjes Bdoi
10.1097/RLI.0000000000000187subject
Has Abstractpub_date
2015-11-01 00:00:00pages
792-7issue
11eissn
0020-9996issn
1536-0210journal_volume
50pub_type
杂志文章abstract:OBJECTIVE:To investigate the feasibility of an 80-kVp protocol using a moderate concentration contrast material (MC-CM) for cerebral computed tomography angiography by comparison with a conventional 120-kVp protocol using a high concentration contrast material (HC-CM). MATERIALS AND METHODS:Attenuation values and sign...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31823076a4
更新日期:2012-02-01 00:00:00
abstract::Simultaneous inflation of two balloons may be necessary for balloon dilation valvuloplasty in patients with a large annulus. We examined the cardiovascular effects of dilating the pulmonary annulus with two balloons in 18 normal dogs using pulsed Doppler ultrasound and gross and microscopic examination. When the ratio...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198808000-00005
更新日期:1988-08-01 00:00:00
abstract::Biplane angiocardiography has emerged as a standard method for calculating left ventricular volume measurements. Validation of such measurements has separately been made for several projections of silicone casts of the left ventricle. This study was undertaken to establish and compare the regression lines for left ven...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198011000-00002
更新日期:1980-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Optimal dose schedules and total dose of ionizing radiation for human central nervous system malignancy are not known. An animal model has been developed for the investigation of rat central nervous system response to proton irradiation using magnetic resonance imaging (MRI). A clinical MRI dev...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199504000-00003
更新日期:1995-04-01 00:00:00
abstract::An allergic, immunologic mechanism for certain adverse reactions to radiocontrast agents has been postulated on the basis of clinical and theoretical considerations. One obstacle to the acceptance of this allergic theory has been the inability to demonstrate significant antibodies with specificity for these agents. In...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197609000-00002
更新日期:1976-09-01 00:00:00
abstract:OBJECTIVES:The safety of nonionic contrast agents with that of ionic iodinated contrast agents in children is compared. METHODS:A comprehensive literature search was conducted to identify all publications on the safety profile of nonionic contrast agents administered intravenously to children. This information was com...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/00004424-199311001-00027
更新日期:1993-11-01 00:00:00
abstract::The authors compared the renal toxicity of the low osmolality radiocontrast agents, iohexol and ioxaglate, and the ionic agent, iothalamate, at equivalent iodine dose, using experimental models in vitro and in vivo. In isolated perfused rat kidneys, all agents induced comparable biphasic hemodynamic changes, associate...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199104000-00008
更新日期:1991-04-01 00:00:00
abstract:PURPOSE:To evaluate the technical feasibility of high spatial resolution contrast-enhanced magnetic resonance angiography (CE-MRA) with highly accelerated parallel acquisition at 3.0 T using a 32-channel phased array coil, and a high relaxivity contrast agent. MATERIALS AND METHODS:Ten adult healthy volunteers (5 men,...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000261937.77365.6a
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVES:Demonstrate the usability of a new polyetheretherketone (PEEK)-based MR-compatible guidewire for renal artery catheterization, angioplasty, and stenting under MR-guidance using MR-visible markers, in vitro and in vivo. MATERIAL AND METHODS:The new 0.035'' guidewire with fiber-reinforced PEEK core, a soft ti...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31819b00f1
更新日期:2009-04-01 00:00:00
abstract::Using cardiac-gated fast acquisition with multiple excitation (FAME), time curves of the cerebral aqueduct signals were derived in 19 healthy volunteers and 14 patients. A mean curve of the normal subjects was determined during systole. A relatively stable point of time was found at 270 msec after the R-wave supposed ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198911000-00004
更新日期:1989-11-01 00:00:00
abstract:OBJECTIVE:Dynamic ventilation (3)He-MRI is a new method to assess pulmonary gas inflow. As differing airway diameters throughout the ventilatory cycle can influence gas inflow this study intends to investigate the influence of volume and timing of a He gas bolus with respect to the beginning of the tidal volume on insp...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181690111
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the feasibility of kidney stone composition analysis using spectral detector computed tomography scanner (SDCT) with normal- and low-dose imaging protocols. METHODS:A total of 154 stones harvested from nephrolithotripsy or nephrolithotomy with a known monocrystalline...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000468
更新日期:2018-08-01 00:00:00
abstract::Early detection of pancreatic ductal adenocarcinoma (PDAC) represents the most significant step toward the treatment of this aggressive lethal disease. Previously, we engineered a preclinical Thy1-targeted microbubble (MBThy1) contrast agent that specifically recognizes Thy1 antigen overexpressed in the vasculature of...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000697
更新日期:2020-11-01 00:00:00
abstract::The magnitude and timing of the effects of postural change on pulmonary blood flow distribution were studied in dogs by means of computed tomography (CT) and radioactive microspheres. A change in the mean attenuation values was demonstrated by CT in the anterior and posterior lung zones after change from the supine to...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198211000-00007
更新日期:1982-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors studied the long-term distribution of gadolinium (Gd) in mice and rats after the administration of four commercially available magnetic resonance imaging contrast media. The goals were to determine any possible product dissociation in vivo and to evaluate the effects that product ex...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199506000-00008
更新日期:1995-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate the short-term effects of a new nitinol stent on canine arteries. METHODS:Eighteen nitinol mesh stents were placed in abdominal aortas, common iliac arteries, and renal arteries of six dogs. Angiography was performed to evaluate the patency rates and structural changes of arteries ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199905000-00007
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to elucidate the mechanism of hepatic parenchyma-specific contrast of Sonazoid (microbubble contrast agent) using microscopic techniques. MATERIALS AND METHODS:Sonazoid was intravenously injected into rats to investigate the microbubble dynamics and distribution within hepatic...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31805f2682
更新日期:2007-09-01 00:00:00
abstract::Using real-time ultrasound, the motions of the tongue, hyoid bone, and larynx were monitored and timed during swallowing in ten normal subjects. A well-defined propulsive wave of the tongue was observed during swallowing a 5-cc water bolus. The body of the hyoid bone was identified on the ultrasound scan as a high ech...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198403000-00003
更新日期:1984-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To compare the diagnostic efficacy of a standard dose of MRI contrast agent in the evaluation of primary brain tumors and metastases using a high-field 3 tesla MR unit versus a 1.5 tesla MR unit. METHODS:Sixteen patients with brain tumors were examined at both field strengths using identical a...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200203000-00003
更新日期:2002-03-01 00:00:00
abstract::The ideal contrast agent in patients suspected of having gastrointestinal perforation is an iso-osmolar, or nearly iso-osmolar substance, that causes no peritoneal reaction. Iopamidol is a nonionic water-soluble contrast medium that may be considered in such situations. Intraperitoneal injections of ionic and nonionic...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199002000-00008
更新日期:1990-02-01 00:00:00
abstract:OBJECTIVE:Hydration is widely accepted as an effective measure to prevent contrast media (CM)-induced acute kidney injury (AKI). Whether bicarbonate (NaHCO₃) infusion has a greater effect than saline is disputed. Effective prevention of CM-induced AKI by NaHCO₃ has been found by several clinical trials. However, others...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31822311a9
更新日期:2011-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors differentiate acute tubular necrosis from transplant rejection in patients with delayed kidney graft function using gadolinium (Gd)-DTPA enhanced magnetic resonance (MR) imaging. METHODS:Twenty-four patients after renal transplantation (10 with normal graft function, 14 with delaye...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/00004424-199606000-00009
更新日期:1996-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:It is widely believed that down-sizing catheters, and possibly needles, will decrease damage to the entry vessel in the performance of angiography. The purposes of this in vitro experiment are to determine if smaller needles produce less arterial wall damage than larger needles and to assess th...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199210000-00001
更新日期:1992-10-01 00:00:00
abstract:PURPOSE:The aim of this study was to develop a method to delineate the lethally frozen-tissue region (temperature less than -40°C) arising from interventional cryoablation procedures using a short tau inversion-recovery ultrashort echo-time (STIR-UTE) magnetic resonance (MR) imaging sequence. This method could serve as...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000642
更新日期:2020-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Target-specific magnetic resonance (MR) contrast agents are being developed to improve the accuracy of MR imaging. The purpose of this study was to determine the mechanism of cell uptake, and modes of intracellular trafficking of a prototypical iron oxide label (RMA) used in the synthesis of so...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199510000-00006
更新日期:1995-10-01 00:00:00
abstract::Observation of the relaxivity of MRI contrast media over a wide range of magnetic fields is not only necessary for predicting their efficiency at any field but also compulsory for understanding and improving their mechanisms of action. The best experimental approach to this problem is the field cycling method, which a...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198809001-00047
更新日期:1988-09-01 00:00:00
abstract::Gastrografin and Amipaque with identical iodine content and flavoring were orally administered in 100 ml doses to 10 healthy volunteers in a double-blind crossover study. The nonionic Amipaque has only about one third of the osmolality of Gastrografin, and draws less fluid into the bowel lumen. Consequently there is l...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/00004424-197811000-00008
更新日期:1978-11-01 00:00:00
abstract::Blood samples from previous contrast reactors and nonreactor controls were incubated with diatrizoate and several contrast analogues. Total complement levels were assayed. All the agents caused complement activation generally proportional to their concentration. Reactors' sera responded to lower concentrations of cont...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198307000-00018
更新日期:1983-07-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/magnetic resonance (MR) (with and without diffusion-weighted imaging [DWI]) to F-FDG PET/computed tomography (CT), with regard to the assessment of nodal and extranodal involvement, in patients with Hodgkin lym...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000218
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:Cardiac magnetic resonance imaging (MRI) at 3.0 T has recently become available and potentially provides a significant improvement of tissue contrast in T1-weighted imaging techniques relying on Gd-based contrast enhancement. Imaging at high-field strength may be especially advantageous for methods relying on...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/01.rli.0000233321.82194.09
更新日期:2006-09-01 00:00:00