Contrast media-induced renal tubular vacuolization. A light and electron microscopic study on rat kidneys.

Abstract:

:The morphologic changes in healthy rat kidneys (n = 102) were studied 2 or 48 hours after intravenous injection of 1 or 3 g iodine (I)/kg of high-osmolality diatrizoate, low-osmolality iopromide and iohexol, or iso-osmolality iotrolan, as well as after 0.2 or 0.6 g/kg of the high-osmolality magnetic resonance contrast medium gadolinium DTPA. Physiologic saline was injected in controls. The kidneys were fixed by perfusion and the specimens were analyzed semiquantitatively by two independent observers blinded to the treatment. A statistically significant (P less than .01) cytoplasmic vacuolization was noticed in the proximal convoluted tubule cells 2 hours after injection of 3 g I/kg of diatrizoate or iopromide. Iohexol and iotrolan induced an even more significant (P less than .01) and longer-lasting vacuolization, but gadolinium DTPA did not produce lysosomal alterations. Although the vital cell organelles remained intact, reversible lysosomal alterations may represent the first structural signs of a threatening cellular injury.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Tervahartiala P,Kivisaari L,Kivisaari R,Virtanen I,Standertskjöld-Nordenstam CG

doi

10.1097/00004424-199110000-00009

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

882-7

issue

10

eissn

0020-9996

issn

1536-0210

journal_volume

26

pub_type

杂志文章
  • Low-osmolality contrast media-induced ventricular fibrillation.

    abstract::We evaluated the incidence of ventricular fibrillation with low-osmolality contrast media by right coronary arteriography in eleven adult mongrel dogs. Following insertion of the catheter into the right coronary artery, a test solution was infused for 25 seconds (total 11 mL) or until fibrillation occurred. The test s...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198904000-00008

    authors: Hayakawa K,Yamashita K

    更新日期:1989-04-01 00:00:00

  • Experimental renal papillary necrosis in rats: microangiographic and tubular micropuncture injection studies.

    abstract::Proposed causes of renal papillary necrosis (RPN) include tubular toxicity due to hyperconcentration of toxins in the renal medulla and vasoconstriction of medullary vessels with ischemic necrosis. The authors studied these mechanisms in bromoethylamine hydrobromide-induced RPN in rats by microvascular and tubular mic...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198103000-00006

    authors: Cuttino JT Jr,Goss FU,Clark RL,Marr MC

    更新日期:1981-03-01 00:00:00

  • CTA contrast enhancement of the aorta and pulmonary artery: the effect of saline chase injected at two different rates in a canine experimental model.

    abstract:OBJECTIVE:To investigate the effect of saline chase injected at 2 different rates on computed tomography (CT) angiography. MATERIALS AND METHODS:This study was approved by our institutional animal study committee. Three injection protocols were used; contrast injection (24 mL, 0.8 mL/s) without saline chase (protocol ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e318032a9fe

    authors: Lee CH,Goo JM,Bae KT,Lee HJ,Kim KG,Chun EJ,Park CM,Im JG

    更新日期:2007-07-01 00:00:00

  • Photographic unsharp masking in chest radiography.

    abstract::A photographic unsharp masking technique for improving the latitude of chest radiographs without sacrificing image contrast or detail is described. An unsharp mask film, prepared from a scout film of the patient's chest, is placed between the film and the front (entrance) screen in the cassette. A second radiograph th...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198107000-00007

    authors: Sorenson JA,Niklason LT,Nelson JA

    更新日期:1981-07-01 00:00:00

  • Molecular magnetic resonance imaging allows the detection of activated platelets in a new mouse model of coronary artery thrombosis.

    abstract:OBJECTIVE:: The final event leading to myocardial infarction is adhesion and activation of platelets after rupture of an atherosclerotic plaque, ending in thrombotic occlusion of the coronary artery. Imaging of imminent vessel occlusion may improve patient care. The feasibility of molecular magnetic resonance imaging (...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e31821e62fb

    authors: Duerschmied D,Meißner M,Peter K,Neudorfer I,Roming F,Zirlik A,Bode C,von Elverfeldt D,von Zur Muhlen C

    更新日期:2011-10-01 00:00:00

  • Application of direct cannulation and injection lymphangiography to the study of the canine cardiac and pulmonary efferent mediastinal lymphatics.

    abstract::Lymphangiograms of canine cardiac and pulmonary efferent mediastinal lymphatics were made by cannulation and injection of Ethiodol. Injections were made singly and serially. The mediastinal lymphatics and lymph nodes, which constitute the pathways of drainage of the heart and lungs, were delineated from the point of c...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197901000-00012

    authors: Leeds SE,Uhley HN,Meister RB

    更新日期:1979-01-01 00:00:00

  • Magnetization Transfer Imaging Predicts Porcine Kidney Recovery After Revascularization of Renal Artery Stenosis.

    abstract:MATERIALS AND METHODS:Stenotic kidney (STK) and contralateral kidney magnetization transfer ratios (MTRs; Mt/M0) were measured at 3.0-T magnetic resonance imaging, at offset frequencies of 600 and 1000 Hz, before and 1 month post-PTRA in 7 RVD pigs. Stenotic kidney MTR was correlated to renal perfusion, renal blood flo...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000711

    authors: Afarideh M,Jiang K,Ferguson CM,Woollard JR,Glockner JF,Lerman LO

    更新日期:2021-02-01 00:00:00

  • Pediatric angiocardiography with iohexol.

    abstract::A nonionic contrast medium (iohexol) was evaluated for safety and efficacy in pediatric angiocardiography in this study of 15 patients, age 6 to 82 months. Patients carried a preliminary diagnosis of congenital heart disease. Subjects were injected with iohexol, 350 mg iodine/ml of solution with an average volume of 2...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:

    authors: Carlsson EC,Rudolph A,Stanger P,Teitel D,Weber W,Yoshida H

    更新日期:1985-01-01 00:00:00

  • Comparing kidney perfusion using noncontrast arterial spin labeling MRI and microsphere methods in an interventional swine model.

    abstract:OBJECTIVE:The purpose of this study was to assess the ability of a flow-sensitive alternating inversion recovery-arterial spin labeling (FAIR-ASL) technique to track renal perfusion changes during pharmacologic and physiologic alterations in renal blood flow using microspheres as a gold standard. MATERIALS AND METHODS...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3181f5e101

    authors: Artz NS,Wentland AL,Sadowski EA,Djamali A,Grist TM,Seo S,Fain SB

    更新日期:2011-02-01 00:00:00

  • Multislice CT angiography of the iliac arteries in the presence of various stents: in vitro evaluation of artifacts and lumen visibility.

    abstract:RATIONALE AND OBJECTIVES:To evaluate the imaging characteristics of various iliac artery stents and stent-grafts in a multislice, computed tomography angiography (MSCTA) phantom study. METHODS:Twelve types of stents and three stent-grafts made of different materials (steel, nitinol, tantalum, cobalt-based alloy) were ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200112000-00004

    authors: Maintz D,Fischbach R,Juergens KU,Allkemper T,Wessling J,Heindel W

    更新日期:2001-12-01 00:00:00

  • Magnetic resonance imaging and histologic findings of experimental cerebral fat embolism.

    abstract:RATIONALE AND OBJECTIVES:The purpose of this study was to determine whether cerebral fat embolism demonstrated reversible or irreversible findings in magnetic resonance (MR) imaging over time and to compare the features in MR images with histologic findings in a cat model. MATERIALS AND METHODS:MR images were obtained...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000077055.48406.e2

    authors: Kim HJ,Lee CH,Lee SH,Moon TY

    更新日期:2003-10-01 00:00:00

  • Preclinical profile of the monodisperse iodinated macromolecular blood pool agent P743.

    abstract:RATIONALE AND OBJECTIVES:To summarize the chemical synthesis, physicochemical characterization, pharmacokinetic behavior, and biological evaluation of P743, a new macromolecular iodinated contrast medium. METHODS:The synthesis and molecular modeling of the iodinated macromolecule P743 are described. The pharmacokineti...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200101000-00006

    authors: Idée JM,Port M,Robert P,Raynal I,Prigent P,Dencausse A,Le Greneur S,Tichkowsky I,Le Lem G,Bourrinet P,Mugel T,Benderbous S,Devoldere L,Bourbouze R,Meyer D,Bonnemain B,Corot C

    更新日期:2001-01-01 00:00:00

  • Design of an isolated pig heart preparation for positron emission tomography and magnetic resonance imaging.

    abstract:RATIONALE AND OBJECTIVES:Validation of new positron emission tomography (PET) tracers or magnetic (MR) imaging contrast agents is based on isolated rodent heart preparations. The use of larger animals could provide a more direct validation using the devices used for humans. METHODS:An isolated pig heart preparation ha...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199711000-00010

    authors: Casali C,Obadia JF,Canet E,Bendjelid K,André-Fouët X,Revel D,Janier MF

    更新日期:1997-11-01 00:00:00

  • The etiology and implications of dense cavitary "photopenia" on myocardial perfusion scintigraphy.

    abstract::Dense cavitary "photopenia" was observed on 21 of 200 consecutive stress perfusion scintigrams. A prominent finding in many cases, it sometimes occupied only a portion of the region overlying the ventricular cavity, was often seen in some projections and not others, and was frequently adjacent to myocardial perfusion ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198507000-00009

    authors: Dae M,Canhasi B,Botvinick E,Olvera S,Schechtmann N,Engelstad B,Hattner R,Schiller N,O'Connell W,Faulkner D

    更新日期:1985-07-01 00:00:00

  • The blood-brain barrier: effects of nonionic contrast media with and without addition of Ca2+ and Mg2+.

    abstract::Trypan blue and 197HgCl2 were used as markers of the increased leakage through the blood-brain barrier which developed after selective injection of different contrast media formulations into the internal carotid arteries of rabbits. Interest was focused on a new, experimental, nonionic medium (C-29) and possible effec...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197907000-00007

    authors: Golman K

    更新日期:1979-07-01 00:00:00

  • Magnetic resonance imaging-guided percutaneous biopsy of mediastinal masses: diagnostic performance and safety.

    abstract:OBJECTIVE:The objective of this study was to evaluate the diagnostic performance and safety of magnetic resonance (MR) imaging-guided percutaneous mediastinal biopsy procedures using a 0.23-T open MR system with optical tracking navigation. MATERIALS AND METHODS:A retrospective analysis of 59 participants (38 males an...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章

    doi:10.1097/RLI.0b013e31827a4a17

    authors: Lü Y,Fritz J,Li C,Liu M,Lee P,Wu L,Carrino JA

    更新日期:2013-06-01 00:00:00

  • Postmortem metabolic and morphologic alterations of the dog brain thalamus with use of in vivo 1H magnetic resonance spectroscopy and electron microscopy.

    abstract:RATIONALE AND OBJECTIVES:To investigate postmortem metabolic and morphologic alterations in the dog brain thalamus and to contribute diagnostic aids in medicolegal science. METHODS:A homogeneous group of 17 dogs was used for in vivo 1H magnetic resonance (MR) spectroscopy and electron microscopic studies, which were p...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199505000-00001

    authors: Choe BY,Gil HJ,Suh TS,Shinn KS

    更新日期:1995-05-01 00:00:00

  • Digital radiography versus conventional radiography for the detection of a skull fracture under varying exposure parameters.

    abstract:RATIONALE AND OBJECTIVES:The effect of varying exposure parameters on the detectability of a fracture with digital and conventional radiography were examined. METHODS:A macerated fractured skull was imaged by film-screen radiography (FSR) and digital storage phosphor radiography (DR) with various exposure values. Five...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199303000-00010

    authors: Langen HJ,Klein HM,Wein B,Schiwy-Bochat KH,Stargardt A,Günther RW

    更新日期:1993-03-01 00:00:00

  • Time course of satisfaction of search.

    abstract::"Satisfaction of search" (SOS) refers to the effect in which a second lesion remains undetected after detection of another lesion on the same radiograph. The objective of this study was to clarify our understanding of SOS by relating it to total time of inspection and time intervals before, between, and after discover...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199107000-00003

    authors: Berbaum KS,Franken EA Jr,Dorfman DD,Rooholamini SA,Coffman CE,Cornell SH,Cragg AH,Galvin JR,Honda H,Kao SC

    更新日期:1991-07-01 00:00:00

  • T2-Weighted 4D Magnetic Resonance Imaging for Application in Magnetic Resonance-Guided Radiotherapy Treatment Planning.

    abstract:OBJECTIVES:The aim of this study was to develop and verify a method to obtain good temporal resolution T2-weighted 4-dimensional (4D-T2w) magnetic resonance imaging (MRI) by using motion information from T1-weighted 4D (4D-T1w) MRI, to support treatment planning in MR-guided radiotherapy. MATERIALS AND METHODS:Ten pat...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000381

    authors: Freedman JN,Collins DJ,Bainbridge H,Rank CM,Nill S,Kachelrieß M,Oelfke U,Leach MO,Wetscherek A

    更新日期:2017-10-01 00:00:00

  • Magnetic resonance imaging assays for dimethyl sulfoxide effect on cancer vasculature.

    abstract:OBJECTIVES:To evaluate the potential of quantitative assays of vascular characteristics based on dynamic contrast-enhanced magnetic resonance imaging (MRI) using a macromolecular contrast medium (MMCM) to search for and measure effects of dimethyl sulfoxide (DMSO) on cancer vasculature with microscopic correlations. M...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e318164b71d

    authors: Cyran CC,Sennino B,Chaopathomkul B,Fu Y,Rogut V,Shames DM,Wendland MF,McDonald DM,Brasch RC

    更新日期:2008-05-01 00:00:00

  • Assessment of cerebral blood flow in man by video dilution technique: a preliminary report.

    abstract::Video dilution technique (VDT) is currently performed in conjunction with routine cerebral angiography to determine carotid blood flow in humans. Preliminary results indicate that the blood flows (as a percentage of cardial output) of the common, internal, and external carotid arteries are 8.5%, 5.5%, and 3.0%, respec...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198105000-00004

    authors: Lantz BM,Dublin AB,McGahan JP,Link DP

    更新日期:1981-05-01 00:00:00

  • A preliminary study of MRI quantification of simulated calcified pulmonary nodules.

    abstract::The potential of magnetic resonance imaging (MRI) quantification of calcium for the evaluation of pulmonary nodules was investigated in simulated nodules. Calcium salts do not contain mobile protons and thus have no signal on MR proton images. To determine whether the absence of signal from partially calcified nodules...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198711000-00001

    authors: Gamsu G,de Geer G,Cann C,Müller N,Brito A

    更新日期:1987-11-01 00:00:00

  • Acquired cystic disease of the kidneys. Computed tomography and ultrasonography appraisal in patients on peritoneal and hemodialysis.

    abstract::Screening chronic hemodialysis patients (CHD) for acquired cystic disease of the kidneys (ACDK) and its complications (hemorrhage and neoplasm) has become accepted management. We evaluated patients on CHD as well as patients on chronic peritoneal dialysis (CPD) for ACDK. The kidneys of 80 chronic dialysis patients wer...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:

    authors: Jabour BA,Ralls PW,Tang WW,Boswell WD Jr,Colletti PM,Feinstein EI,Massry SG

    更新日期:1987-09-01 00:00:00

  • Mechanism of hepatic parenchyma-specific contrast of microbubble-based contrast agent for ultrasonography: microscopic studies in rat liver.

    abstract:OBJECTIVE:The objective of this study was to elucidate the mechanism of hepatic parenchyma-specific contrast of Sonazoid (microbubble contrast agent) using microscopic techniques. MATERIALS AND METHODS:Sonazoid was intravenously injected into rats to investigate the microbubble dynamics and distribution within hepatic...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e31805f2682

    authors: Watanabe R,Matsumura M,Munemasa T,Fujimaki M,Suematsu M

    更新日期:2007-09-01 00:00:00

  • The effects of ioxaglate 320, iohexol 350, and iopamidol 370 on erythrocyte aggregation.

    abstract::The authors report a randomized, double-blind prospective trial comparing the effects of nonionic with ionic low-osmolar contrast media on erythrocyte aggregation. The study group comprised 40 consecutive patients with pathology necessitating selective angiography. Patients were examined using either ioxaglate 320, io...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004424-199108000-00009

    authors: Hayes R,Mahon T,Masterson J,Owens A

    更新日期:1991-08-01 00:00:00

  • Contrast media for CT. An analysis of the early pharmacokinetics.

    abstract::Iohexol and meglumine-sodium diatrizoate were injected intravenously into 18 pigs as either a 99:1 or 1:99 mixture. Blood samples were taken for 30 minutes and the concentration of each of the two contrast media was measured by means of a double labeling technique with 125I and 131I. Relative concentrations of iohexol...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198511000-00016

    authors: Jensen LI,Dean PB,Nyman U,Golman K

    更新日期:1985-11-01 00:00:00

  • Impact of Impaired Renal Function on Gadolinium Retention After Administration of Gadolinium-Based Contrast Agents in a Mouse Model.

    abstract:OBJECTIVES:The aim of this study was to investigate the impact of impaired renal function on gadolinium (Gd) retention in various organs after Gd-based contrast agent injection. MATERIALS AND METHODS:After local animal care and review committee approval, 23 normal mice and 26 with renal failure were divided into 4 tre...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000295

    authors: Kartamihardja AA,Nakajima T,Kameo S,Koyama H,Tsushima Y

    更新日期:2016-10-01 00:00:00

  • Evaluation of the integrity of the blood-brain barrier after meningeal trauma.

    abstract:RATIONALE AND OBJECTIVES:The authors used magnetic resonance imaging (MRI) techniques to examine the effect of meningeal trauma produced by cisterna magna puncture on the integrity of the blood-cerebrospinal fluid barrier (BCB) in a rat model. METHODS:Intravenous gadolinium-DTPA (Gd-DTPA), a relaxation rate modifier w...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199204000-00008

    authors: Walker JD,Martin MA,Potts DG,Lemaire C,Templeton DM

    更新日期:1992-04-01 00:00:00

  • 18F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance in Lymphoma: Comparison With 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and With the Addition of Magnetic Resonance Diffusion-Weighted Imaging.

    abstract:OBJECTIVES:The aim of this study was to compare F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/magnetic resonance (MR) (with and without diffusion-weighted imaging [DWI]) to F-FDG PET/computed tomography (CT), with regard to the assessment of nodal and extranodal involvement, in patients with Hodgkin lym...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000218

    authors: Giraudo C,Raderer M,Karanikas G,Weber M,Kiesewetter B,Dolak W,Simonitsch-Klupp I,Mayerhoefer ME

    更新日期:2016-03-01 00:00:00