Abstract:
OBJECTIVE:The objective of this study was to elucidate the mechanism of hepatic parenchyma-specific contrast of Sonazoid (microbubble contrast agent) using microscopic techniques. MATERIALS AND METHODS:Sonazoid was intravenously injected into rats to investigate the microbubble dynamics and distribution within hepatic microcirculation in exteriorized liver using intravital microscopy and to observe dose dependency of ultrasound hepatic contrast effect. In vitro and in vivo uptake of microbubbles by Kupffer cells was examined using confocal laser scanning microscopy. RESULTS:Intravital observation demonstrated freely flowing microbubbles in the sinusoid and some microbubbles co-localized with Kupffer cells. The microbubbles internalized in Kupffer cells were identified with reflected light by confocal laser scanning microscopy. The percentage of Kupffer cells taking up microbubbles was about 1% at clinical dose at which the homogeneous hepatic contrast was observed. CONCLUSIONS:The hepatic parenchyma-specific contrast by Sonazoid is due to distribution of the microbubbles in Kupffer cells.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Watanabe R,Matsumura M,Munemasa T,Fujimaki M,Suematsu Mdoi
10.1097/RLI.0b013e31805f2682subject
Has Abstractpub_date
2007-09-01 00:00:00pages
643-51issue
9eissn
0020-9996issn
1536-0210pii
00004424-200709000-00006journal_volume
42pub_type
杂志文章abstract::The microangiographic anatomy of the cat's eye is presented. The characteristic vascular pattern of each of the three distinct circulations, retinal choroidal, and ciliary is described and illustrated. ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197501000-00007
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVES:The purpose of our study was to assess the potential for radiation dose reduction in digital postinterventional digital mammograms after marker placement. MATERIALS AND METHODS:One hundred consecutive cases of marker placement (hook-wire localization or postbiopsy clip marker placement), with 200 full-field...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000163743.63063.9f
更新日期:2005-06-01 00:00:00
abstract::The effect of intravenous urography (IVU) on the excretion rate and precipitation of Tamm-Horsfall glycoprotein (THG) has been evaluated in 19 patients. Urine samples were collected immediately before the administration of contrast medium (U1) and then during the period of the excretion urogram (U2). The urinary THG: ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198501000-00014
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVE:To assess prospectively, in healthy subjects and in patients with dilated cardiomyopathy (DCM) and hypertrophic obstructive cardiomyopathy (HOCM), the 3-dimensional (3D) shape, size, and motion of the mitral annulus (MA) using computed tomography (CT). MATERIALS AND METHODS:Twenty patients with no cardiac ab...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181994a73
更新日期:2009-04-01 00:00:00
abstract::Patients with intracranial arteriovenous malformations (AVM) can expect significant mortality (15% to 20%) and morbidity (20% to 30%) over a 15-year to 20-year period. Recent advances in interventional neuroradiology, neurosurgery, neuroanesthesia, and stereotactic radiotherapy provide the opportunity to obliterate ma...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/00004424-199008000-00014
更新日期:1990-08-01 00:00:00
abstract::Due to the small size of the bronchial arteries, the bronchial circulation is difficult to study and remains poorly understood. We have utilized single photon emission computed tomography (SPECT) as a noninvasive means of studying the bronchial circulation. Imaging studies were performed in sheep before and after the ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199001000-00014
更新日期:1990-01-01 00:00:00
abstract::Prior to the formation of an intravenous digital subtraction angiography (IV-DSA) image, contrast medium passes through the lesser circulation and is diluted by the blood volume of the heart and lungs. If the contrast medium alone influences central blood volume or cardiac output, the shape of the resultant time-conce...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198603000-00009
更新日期:1986-03-01 00:00:00
abstract:MATERIALS AND METHODS:Stenotic kidney (STK) and contralateral kidney magnetization transfer ratios (MTRs; Mt/M0) were measured at 3.0-T magnetic resonance imaging, at offset frequencies of 600 and 1000 Hz, before and 1 month post-PTRA in 7 RVD pigs. Stenotic kidney MTR was correlated to renal perfusion, renal blood flo...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000711
更新日期:2021-02-01 00:00:00
abstract::Twenty-six patients who had received 43 grafts were studied before and after coronary artery vein bypass surgery. Cine ventriculograms taken in the right anterior oblique projection were analyzed and regional ejection fractions calculated. Single and multiple grafts were considered separately as were thrombosed and pa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197705000-00001
更新日期:1977-05-01 00:00:00
abstract::A series of 5-hydroxyacylamino-2,4,6-triiodo-N,N'-hydroxy-alkyl-isophtalamides was prepared in order to study the structural requirements for high water solubility and low toxicity. Among the amides substituted by 2-hydroxyethyl; 2,3-dihydroxypropyl; 1,3-dihydroxypropyl-; and 1,1-dihydroxy-methyl-2-oxyethyl- groups, t...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198011001-00065
更新日期:1980-11-01 00:00:00
abstract::We examined the acute systemic and renal hemodynamic effects of intravenous meglumine/sodium diatrizoate-76% and iopamidol in euvolemic and dehydrated dogs. The physiologic responses were compared with acute changes in the level of an endogenous heparin-like material (EHM). One of eight dehydrated dogs receiving diatr...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198610000-00005
更新日期:1986-10-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the effect of structured reports (SRs) in comparison to nonstructured, free-text (FT) rectal magnetic resonance imaging (MRI) reports in patients with histologically proven rectal cancer and potential effects of both types of reporting on referring surgeons' satisfaction...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000336
更新日期:2017-04-01 00:00:00
abstract::An ultrasound phantom was constructed simulating fetal femurs in amniotic fluid. Bones of 26, 36, 50, 58, and 70 mm, representative of gestational ages ranging from 17 to 36 weeks, were scanned with mechanical sector, phased sector, and linear array systems (ATL, Diasonics, Acuson, and GE). Measurements were made with...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198505000-00016
更新日期:1985-05-01 00:00:00
abstract:OBJECTIVES:Imaging of the kidney using blood oxygen level dependent MR presents a major opportunity to examine differences in tissue oxygenation within the cortex and medulla applicable to human disease. We sought to define the differences between regions within kidneys and to optimize selection of regions of interest ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181b4c1e8
更新日期:2009-09-01 00:00:00
abstract::Post-angioplasty restenosis (PARS) in atherosclerotic lesions of medium and small arteries occurs in about one-third of cases in the first year following percutaneous transluminal angioplasty (PTA) (early PARS). PARS includes acute spasm, dissection with reclosure, elastic recoil, fibrocellular proliferative response,...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/00004424-198811000-00002
更新日期:1988-11-01 00:00:00
abstract::There are a number of sonographic findings seen in fibroadenoma of the breast. In a retrospective study, we examined the biopsy results of 59 masses given the sonographic diagnosis of fibroadenoma. We also reviewed the sonograms of an additional 26 biopsy-proven fibroadenomas that were not diagnosed as such with ultra...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198601000-00006
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVES:Contrast-enhanced ultrasound imaging is increasingly being used in the clinic for assessment of tissue vascularity. The purpose of our study was to evaluate the effect of different contrast administration parameters on the in vivo ultrasound imaging signal in tumor-bearing mice using a maximum intensity pers...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181f9202d
更新日期:2011-03-01 00:00:00
abstract::In vivo and in vitro studies have shown that areas of myocardial infarctions can be delineated on CT scans after intravenous administration of iodinated contrast material to dogs with experimental myocardial infarctions. Within the first minute after intravenous administration of contrast material (initial myocardial ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198011001-00039
更新日期:1980-11-01 00:00:00
abstract:OBJECTIVES:: To evaluate the performance of a gadolinium-based contrast compound (P846) as well as an ultra-small particle of iron oxide agent (P904) in contrast-enhanced magnetic resonance angiography (MRA) in rabbits and to compare those agents with gadoterate meglumine (Gd-DOTA) for first pass and steady state imagi...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31821ae21f
更新日期:2011-08-01 00:00:00
abstract::Receiver operating characteristic (ROC) analysis has been used in a broad variety of medical imaging studies during the past 15 years, and its advantages over more traditional measures of diagnostic performance are now clearly established. But despite the essential simplicity of the approach, workers in the field ofte...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198903000-00012
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVES:To test the feasibility of a single MR-based examination allowing for the comprehensive assessment of renal anatomy, function, and vascular status in candidates for kidney transplantation. MATERIALS AND METHODS:Twelve healthy potential kidney donors (mean age: 47 +/- 14 [standard deviation] years, 3 men and...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/RLI.0b013e3181b35a70
更新日期:2009-11-01 00:00:00
abstract::The importance of evaluating medical student performance has been widely addressed in the medical education literature. Multiple-choice examinations are the preferred method of testing because they are easy to administer and score. Development of parallel or equivalent pre- and post-examinations provides objective inf...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:1986-09-01 00:00:00
abstract::The large intestines of eight boxer dogs with canine histiocytic ulcerative colitis (CHUC) and 10 normal dogs were studied by in vivo angiography and postmortem microangiography. The vascular abnormalities were correlated with the gross and histologic pathology found at necropsy. The angiographic abnormalities were ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197505000-00005
更新日期:1975-05-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the diagnostic performance of virtual noncalcium (VNCa) dual-energy computed tomography (DECT) reconstructions enabling visualization of bone marrow edema for characterization of incidental thoracolumbar compression fractures in routine thoracoabdominal staging computed tom...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000458
更新日期:2018-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:We investigated whether it is possible to investigate degenerative changes in human tissue on a sub-100-microm resolution scale not only on special high-field small-bore MR-microscopy systems but also on a 3T whole-body MR-scanner. METHODS:Spin-spin relaxation, proton density, and diffusion mi...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.RLI.0000068620.17569.83
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVES:To determine the impact of slice thickness on semiautomatic lymph node analysis. MATERIALS AND METHODS:Thoracic multislice computed tomography (MSCT) of 46 patients with NSCLC were reconstructed at 1.0-, 3.0-, and 5.0-mm slice thickness. Two radiologists independently determined long and short axis diameter...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181c443e1
更新日期:2010-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors detect activation in the auditory cortex during cochlear electrical stimulation in deaf patients using functional magnetic resonance (MR) imaging. METHODS:Stimulating electrode was inserted gently under local anesthesia close to the round window membrane of the cochlea in seven coc...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199705000-00007
更新日期:1997-05-01 00:00:00
abstract::The cerebrovascular toxicity of three water-soluble contrast agents with a low hypertonicity (metrizamide, ioxaglate, iopamidol) was tested. Blood-brain barrier damage after carotid injection was assessed using 32P autoradiography and fluorescent microscopy after Evans blue staining. The damage to carotid endothelium ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198011001-00058
更新日期:1980-11-01 00:00:00
abstract::The extent to which various concentrations of the paramagnetic metal ions [gadolinium (III), manganese (II), chromium (III), iron (III), nickel (II), copper (II), and cobalt (II)] affect proton magnetic relaxation times of distilled water, 4% human serum albumin (HSA), and dog plasma was studied in vitro. The pH of wa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198602000-00009
更新日期:1986-02-01 00:00:00
abstract::The effects of edge gradient and blur on the detection pulmonary nodules were studied, using a test series of 175 artificial nodules on 30 chest films. The nodules were of homogeneous texture, about 1 cm in diameter and had a mean contrast of .12. Six observers viewed the film set, scoring both location and confidence...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197901000-00004
更新日期:1979-01-01 00:00:00