Abstract:
OBJECTIVES:To determine the impact of slice thickness on semiautomatic lymph node analysis. MATERIALS AND METHODS:Thoracic multislice computed tomography (MSCT) of 46 patients with NSCLC were reconstructed at 1.0-, 3.0-, and 5.0-mm slice thickness. Two radiologists independently determined long and short axis diameter and volume of 299 thoracic lymph nodes by semiautomatic segmentation software. Necessity of manual correction (= relative difference between uncorrected and corrected segmented lymph node volume) and relative interobserver differences were determined. The precision of segmentation was expressed by relative measurement deviations (RMD) from the reference standard (mean of 1.0 mm datasets). Statistical analysis encompassed t test and Bland-Altman plots. RESULTS:Necessity of manual correction was significantly higher for 5.0 mm than for 3.0 (P = 0.042) or 1.0 mm (P = 0.0012). The RMD for long and short axis diameter were found to be independent of slice thickness, whereas the RMD for lymph node volume significantly (P = 0.021) increased from 4.0% at 1.0 mm (95% CI: 1.0%-3.5%) to 35% at 5.0 mm (95% CI: 10.5%-60.5%). The relative interobserver differences was consistently low for metric and volumetric parameters (eg, volume 2.3%, 95% CI: -7.4%-10.8% at 5.0 mm) with no difference in any of the slice thicknesses (P > 0.064). CONCLUSIONS:Significant deviations in lymph node volume together with excessive manual corrections suggest reconstruction of the data for semiautomatic lymph node assessment at a slice thickness of 1.0 mm but not exceeding 3.0 mm.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Buerke B,Puesken M,Beyer F,Gerss J,Weckesser M,Seifarth H,Heindel W,Wessling Jdoi
10.1097/RLI.0b013e3181c443e1subject
Has Abstractpub_date
2010-02-01 00:00:00pages
82-8issue
2eissn
0020-9996issn
1536-0210journal_volume
45pub_type
杂志文章abstract:OBJECTIVE:There is little published information regarding the efficacy of paclitaxel-coated balloon catheters except for the iopromide-containing formulation, and less is known about the kind of toxicity at overdose. The aim of our study was to assess 2 different paclitaxel matrix formulations on angioplasty balloon ca...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31820577df
更新日期:2011-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Magnetic resonance imaging (MRI) techniques seem to be very promising for 3D dosimetry studies, but long imaging acquisition time limits their use. A new fast T1 mapping protocol, easy to implement on a conventional MR imager, has been used to determine dose distributions on Fricke gels. METHO...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199903000-00014
更新日期:1999-03-01 00:00:00
abstract::Percutaneous injection of absolute ethanol into adenocarcinomas implanted in the hind leg of rats was evaluated as a potential cancer treatment. Intramuscular alcohol injections up to 10 mL/kg produced a local dose-dependent coagulation necrosis followed by granulation tissue formation and subsequent fibrosis but no a...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198706000-00005
更新日期:1987-06-01 00:00:00
abstract::A new technique for the noninvasive measurement of an index of renal blood flow is described. The method utilizes ultrasound determined renal volume and radionuclide assessment of the mean transit time of a pertechnetate bolus through the kidneys. From this information a value for flow is calculated according to compa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198307000-00009
更新日期:1983-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To compare technical aspects and neointima formation of a new Nitinol stent and a Wallstent. METHODS:A Nitinol sten and a Wallstent were placed into the iliac arteries of 14 sheep (total of 28 stents) and followed angiographically. Seven sheep were killed after 1 month and 7 after 4.5 months. ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199507000-00004
更新日期:1995-07-01 00:00:00
abstract:OBJECTIVES:Over the recent years, there have been increasing concerns that exposure to gadolinium-based contrast agents (GBCAs) may be associated with retention of Gd within the skin, bones, and solid organs in patients with normal renal function, although the clinical implications of this deposition remain to be estab...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000657
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:The safety of nonionic contrast agents with that of ionic iodinated contrast agents in children is compared. METHODS:A comprehensive literature search was conducted to identify all publications on the safety profile of nonionic contrast agents administered intravenously to children. This information was com...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/00004424-199311001-00027
更新日期:1993-11-01 00:00:00
abstract::Even though we have made much progress over the last decade, much still needs to be done. I am personally very pleased with the excellent management and authority of my coauthor, Joe Frank, in assuming the Acting Directorship of our DRRP. You will be hearing more from him in the immediate future about this research pr...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199304001-00014
更新日期:1993-04-01 00:00:00
abstract::We evaluated the incidence of ventricular fibrillation with low-osmolality contrast media by right coronary arteriography in eleven adult mongrel dogs. Following insertion of the catheter into the right coronary artery, a test solution was infused for 25 seconds (total 11 mL) or until fibrillation occurred. The test s...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198904000-00008
更新日期:1989-04-01 00:00:00
abstract::Capacity-limited elimination of sodium iopanoate and a reproducible apparent transport maximum (Tm) were demonstrated in nonoperated dogs having an intact enterohepatic circulation and normal endogenous bile salt pool. Using a multiple infusion technique, estimation of apparent Tm of iopanoate in the liver was possibl...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197601000-00007
更新日期:1976-01-01 00:00:00
abstract:PURPOSE:Magnetic Resonance Imaging (MRI) has become the method of choice in the evaluation of patients with suspected cervical artery dissection (CAD). However, reliable identification of acute CAD might be impaired by the limited spatial resolution of standard 1.5 T MRI. In this preliminary study, we implemented a mul...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000195836.57778.1f
更新日期:2006-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Ultrasound can cause destruction of microbubble contrast agents used to enhance medical ultrasound imaging. This study sought to characterize the dynamics of this interaction by direct visual observation of microbubbles during insonification in vitro by a medical ultrasound imaging system. MET...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199812000-00004
更新日期:1998-12-01 00:00:00
abstract::Polylysine covalently linked to moieties of gadopentetate (Gd-DTPA), for use as a macromolecular blood pool marker for contrast material-enhanced magnetic resonance imaging (MRI), was characterized by means of physicochemical measurements and pharmacokinetics in rats and rabbits and compared with Gd-DTPA. Gd-DTPA-poly...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199111000-00008
更新日期:1991-11-01 00:00:00
abstract::An ultrasound phantom was constructed simulating fetal femurs in amniotic fluid. Bones of 26, 36, 50, 58, and 70 mm, representative of gestational ages ranging from 17 to 36 weeks, were scanned with mechanical sector, phased sector, and linear array systems (ATL, Diasonics, Acuson, and GE). Measurements were made with...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198505000-00016
更新日期:1985-05-01 00:00:00
abstract::Over the past 120 years, continuous developments in medical imaging has improved diagnosis and treatment for many diseases and has thereby improved treatment outcome and quality of life of many patients. The number of computed tomography (CT) examinations is today increasing by 4% per year worldwide, for a total of ap...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000696
更新日期:2020-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To assess the potential of magnetic resonance imaging (MRI) for evaluating the evolution of tumor necrosis, the authors evaluated 28 VX2 carcinomas inoculated in the thigh muscles of rabbits. METHODS:MRI of VX2 carcinomas at 2.0 T was done with spin-echo technique 1 week (14 tumors) and 3 week...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199301000-00010
更新日期:1993-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The vasoconstriction of the renal arteries is frequently considered as a crucial factor for radiocontrast-induced nephropathy. A direct effect of iodinated radiographic contrast medium (RCM) on vascular smooth muscle is supposed to be one component of the vascular response. We studied the effec...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200208000-00005
更新日期:2002-08-01 00:00:00
abstract::The feasibility of control of traumatic hepatic hemorrhage by angiographic transcatheter embolization was investigated. Bleeding sites were created in the livers of each of twelve dogs, and the hepatic artery was occluded with Gelfoam. Successful control of bleeding was demonstrated by postembolization angiography in ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197801000-00014
更新日期:1978-01-01 00:00:00
abstract::The magnitude and timing of the effects of postural change on pulmonary blood flow distribution were studied in dogs by means of computed tomography (CT) and radioactive microspheres. A change in the mean attenuation values was demonstrated by CT in the anterior and posterior lung zones after change from the supine to...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198211000-00007
更新日期:1982-11-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to assess the value of in vivo T2 measurements to noninvasively quantify myocardial fibrosis in diabetic mice at 11.75 T. Diabetic cardiomyopathy is characterized by extracellular matrix alteration and microcirculation impairment. These conditions might provide electrical heterogeneit...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e318243e062
更新日期:2012-05-01 00:00:00
abstract::The effects of an intravenously administered nitroxyl spin label (PCA) on the magnetic resonance imaging (MRI) appearance and relaxation times of acute canine myocardial infarctions were studied. Twenty-four hours after ligation of the left anterior descending coronary artery (LAD), animals were either sacrificed imme...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:1985-09-01 00:00:00
abstract:RATIONAL AND OBJECTIVES:The purpose of this study was to evaluate the effects of variation in design parameters on the resultant radial force. We evaluated the influence of wire gauge, leg length, and number of bends on the radial force produced by z stents and compared these with radial forces produced by commercial s...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200109000-00004
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVES:Contrast-enhanced ultrasound imaging is increasingly being used in the clinic for assessment of tissue vascularity. The purpose of our study was to evaluate the effect of different contrast administration parameters on the in vivo ultrasound imaging signal in tumor-bearing mice using a maximum intensity pers...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181f9202d
更新日期:2011-03-01 00:00:00
abstract::Diagnostic radiology is expanding, playing an increasingly central role in patient care, which heightens the importance of radiology teaching in undergraduate medical education. This study examined the impact of increased structure and systematic evaluation on student performance in a radiology elective. The evaluatio...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198505000-00003
更新日期:1985-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:A computerized system that applies the case-based approach to training radiologists to diagnose brain tumors was designed. The authors attempted to provide residents a tool that supports their visual memory and inducts case-based reasoning. METHODS:A relational database with a digital image li...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199404000-00020
更新日期:1994-04-01 00:00:00
abstract::Using a 1.5 T magnetic resonance imaging (MRI) system, cine phase-contrast and magnitude images were obtained in three phantoms that simulated different anatomic configurations of aortic dissection. The dissection phantoms were made of compliant materials, and pulsatile flow was used in all experiments. Phantoms diffe...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199112000-00007
更新日期:1991-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Hepatocellular carcinomas (HCCs) usually consist of components of different histologic grade. Using surgically resected specimens, the authors obtained high-resolution magnetic resonance (MR) images and studied the relationship between histologic grade of HCCs and MR signal intensity. METHOD:I...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199308000-00007
更新日期:1993-08-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to prospectively compare diagnostic performance and time efficiency of a double-reading paradigm in which a first-reader computer-aided detection (CAD) is followed by a fast 2-dimensional review (DR FR-CAD) with those of a double reading with second-reader CAD (SR CAD). MATER...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000009
更新日期:2014-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:We investigated whether it is possible to investigate degenerative changes in human tissue on a sub-100-microm resolution scale not only on special high-field small-bore MR-microscopy systems but also on a 3T whole-body MR-scanner. METHODS:Spin-spin relaxation, proton density, and diffusion mi...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.RLI.0000068620.17569.83
更新日期:2003-07-01 00:00:00
abstract::Attenuation correction (AC) is an essential step in the positron emission tomography (PET) data reconstruction process to provide accurate and quantitative PET images. The introduction of PET/magnetic resonance (MR) hybrid systems has raised new challenges but also possibilities regarding PET AC. While in PET/computed...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
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更新日期:2016-10-01 00:00:00