Saturation kinetics of iopanoate in dogs with an intact enterohepatic circulation. Before and after phenobarbital induction.

Abstract:

:Capacity-limited elimination of sodium iopanoate and a reproducible apparent transport maximum (Tm) were demonstrated in nonoperated dogs having an intact enterohepatic circulation and normal endogenous bile salt pool. Using a multiple infusion technique, estimation of apparent Tm of iopanoate in the liver was possible without sampling either bile or urine. Values obtained for apparent Tm of iopanoate in dogs with normal bile salt pool were similar to those obtained in studies of dogs with chronic bile fistulas. Use of this technique in 4 dogs demonstrated that pretreatment with phenobarbital significantly increases apparent Tm of iopanoate.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Herzog RJ,Nelson JA,Staubus AE

doi

10.1097/00004424-197601000-00007

keywords:

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

32-8

issue

1

eissn

0020-9996

issn

1536-0210

journal_volume

11

pub_type

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