Assessment of osteosarcoma response to preoperative chemotherapy using dynamic FLASH gadolinium-DTPA-enhanced magnetic resonance mapping.

Abstract:

RATIONALE AND OBJECTIVES:To improve the accuracy of magnetic resonance imaging (MRI) in evaluating the response of osteosarcomas to preoperative chemotherapy, the authors developed a technique of mapping tumor necrosis and viability by quantitating slope values of gadolinium-DTPA (Gd-DTPA) uptake on dynamic fast low-angle shot (FLASH) images. METHODS:Dynamic contrast-enhanced FLASH imaging of a single representative plane was performed on six osteosarcomas. Tumors were mapped by dividing resultant images into contiguous regions of interest and deriving slopes representing percentage increase in signal intensity (SI) per minute over the baseline for each region. The results were compared with estimations of viable tumor volume on subtracted Gd-DTPA-enhanced T1-weighted images and histologic maps of necrotic and viable tumor. RESULTS:Dynamic FLASH estimations of percent tumor necrosis using a critical slope value of 45% per minute correctly predicted histologic response to chemotherapy in all six patients. Comparison of dynamic FLASH and histologic maps showed a high degree of correlation. Static enhanced T1-weighted images overestimated the amount of residual viable tumor. CONCLUSIONS:Dynamic FLASH Gd-DTPA-enhanced mapping is a potentially useful noninvasive method of quantitating tumor response to chemotherapy.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Hanna SL,Parham DM,Fairclough DL,Meyer WH,Le AH,Fletcher BD

doi

10.1097/00004424-199205000-00010

keywords:

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

367-73

issue

5

eissn

0020-9996

issn

1536-0210

journal_volume

27

pub_type

杂志文章
  • Comparative cranial CT enhancement in the normal primate.

    abstract::The application of intravenous, intrathecal, and inhalation enhancement techniques to the CT evaluation of the nonhuman primate (Papio cynocephalus/anubis) is described. The falx cerebri cortical vasculature, vein of Galen, straight sinus and tentorium cerebelli were defined with intravenous enhancement. Intrathecal C...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197901000-00014

    authors: Drayer BP,Wolfson SK Jr,Rosenbaum AE,Dujovny M,Boehnke M,Cook EE

    更新日期:1979-01-01 00:00:00

  • Intravascular ultrasound imaging of vascular responsiveness in isolated perfused canine arteries.

    abstract::We investigated the feasibility of using intravascular ultrasound imaging to analyze vascular physiology in various arterial beds. Canine superficial femoral, external iliac, and common carotid arteries were harvested and suspended and perfused in a bath of oxygenated, heated, physiologic salt solution. A 6-Fr, 20-MHz...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199103000-00010

    authors: Wilson MW,Webb RC,Marx MV,Meyer CR,Gallagher MA,Haarer SL,Buda AJ,Williams DM

    更新日期:1991-03-01 00:00:00

  • Contrast media-induced chromosomal damage in human lymphocyte cultures.

    abstract::Ionic (diatrizoate, ioxaglate) and nonionic (iohexol, iosimide, iopromide, and iotrolan) contrast media (CM) were evaluated for their cytogenetic effects in lymphocytes. Heparinized blood was mixed with culture medium RPMI-1640 supplemented with phytohemagglutinin, fetal calf serum, and antibiotics. Plastic tubes cont...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198611000-00006

    authors: Parvez Z,Kormano M,Moncada R,Eklund R

    更新日期:1986-11-01 00:00:00

  • Hepatic kinetics and magnetic resonance imaging of gadolinium-EOB-DTPA in dogs.

    abstract:RATIONALE AND OBJECTIVES:To measure the hepatic uptake and biliary elimination kinetics of gadolinium (Gd)-EOB-DTPA in dogs. METHOD:Two groups of four beagles each were anesthetized and given an intravenous bolus of 25 mumol/kg or 250 mumol/kg of Gd-EOB-DTPA. Blood, hepatic bile, and urine were collected over 140 minu...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199604000-00005

    authors: Benness G,Khangure M,Morris I,Warwick A,Burrows P,Vogler H,Weinmann HJ

    更新日期:1996-04-01 00:00:00

  • Osteosarcoma of the nude rat. A model for experimental magnetic resonance imaging studies of bone tumors.

    abstract::A 144cerium-induced osteosarcoma was transplanted to athymic nude rats (Han:rnu/rnu). Nineteen of the tumor-bearing animals were used to demonstrate the characteristics of the osteosarcoma on magnetic resonance imaging (MRI) in comparison with a group of nine animals that had not received any tumor transplant. The tum...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:

    authors: Witzel JG,Bohndorf K,Prescher A,Adam G

    更新日期:1992-03-01 00:00:00

  • Collateral arterial formation. Lymph draining ischemic kidneys contains a neovascular stimulating agent of high molecular weight.

    abstract::An agent has been identified in lymph from rat kidneys rendered ischemic by partial renal artery occlusion that induces a striking neovascular response in a hamster cheek-pouch assay system. The factor has a high molecular weight, cannot be identified in lymph from normal kidneys, and is associated with a marked incre...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198501000-00015

    authors: Hollenberg NK,Paskins-Hurlburt AJ,Abrams HL

    更新日期:1985-01-01 00:00:00

  • Efficacy of gadoteridol for magnetic resonance imaging of the brain and spine.

    abstract:RATIONALE AND OBJECTIVES:The efficacy of gadoteridol for contrast enhancement of central nervous system pathology was assessed in a multicenter clinical trial involving 411 patients suspected of having intracranial or spinal pathology. METHODS:Magnetic resonance imaging was performed before and after intravenous admin...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Runge VM,Bronen RA,Davis KR

    更新日期:1992-08-01 00:00:00

  • The radiation dosimetry and normal value study of 99mTc-HMPAO-labeled leukocytes.

    abstract:RATIONALE AND OBJECTIVES:Indium-111 (111In)-labeled leukocyte scanning has been used frequently in patients suspected of having infections. Recently, technetium-99m hexamethylpropylene amine oxime (99mTc-HMPAO) has been used to label leukocytes. This study was undertaken to determine the distribution and dosimetry of 9...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199404000-00010

    authors: Brown ML,Hung JC,Vetter RJ,O'Connor MK,Chowdhury S,Forstrom LA

    更新日期:1994-04-01 00:00:00

  • Pulmonary microangiography. A comparison of in vitro versus in vivo perfusion techniques in dogs.

    abstract::Because of a need to correlate pulmonary microvascular changes with physiologic data during lung injury, in vitro and in vivo pulmonary capillary microangiography was performed on normal dogs and those subjected to oleic acid injury and glass bead microembolization. During these studies, no significant differences wer...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:

    authors: Clark RL,Friedman M,Kwock L,Zaremba J

    更新日期:1983-01-01 00:00:00

  • Educational objectives for diagnostic radiology residency training.

    abstract::A method of teaching radiology residents by identification of general and specific objectives to be accomplished during each time segment of the four-year training program has been developed. The objectives are incorporated into an educational contract that is signed by the resident and rotation director at the beginn...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198612000-00009

    authors: Howland WJ,Marler D,Bosshart D

    更新日期:1986-12-01 00:00:00

  • Targeted Biopsy Validation of Peripheral Zone Prostate Cancer Characterization With Magnetic Resonance Fingerprinting and Diffusion Mapping.

    abstract:OBJECTIVE:This study aims for targeted biopsy validation of magnetic resonance fingerprinting (MRF) and diffusion mapping for characterizing peripheral zone (PZ) prostate cancer and noncancers. MATERIALS AND METHODS:One hundred four PZ lesions in 85 patients who underwent magnetic resonance imaging were retrospectivel...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000569

    authors: Panda A,OʼConnor G,Lo WC,Jiang Y,Margevicius S,Schluchter M,Ponsky LE,Gulani V

    更新日期:2019-08-01 00:00:00

  • Granulocyte accumulation in the transplanted liver does not correlate with clinical and histologic evidence of dysfunction.

    abstract:RATIONALE AND OBJECTIVES:To evaluate the role of granulocytes in reperfusion injury after liver transplantation. The authors injected radiolabeled granulocytes to determine if human liver graft outcome could be correlated with granulocyte accumulation. MATERIALS AND METHODS:Pure granulocyte suspension was prepared fro...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199603000-00003

    authors: Ziser A,Forstrom LA,Plevak DJ,Sanchez-Urdazpal L,Gores GJ,Wiesner RH,Batts KP,Krom RA

    更新日期:1996-03-01 00:00:00

  • Comparison of the Relaxivities of Macrocyclic Gadolinium-Based Contrast Agents in Human Plasma at 1.5, 3, and 7 T, and Blood at 3 T.

    abstract:PURPOSE:The relaxivities of 3 macrocyclic gadolinium-based contrast agents (GBCAs) were determined in human plasma and blood under standardized and clinically relevant laboratory conditions. METHODS:The T1 relaxivity, r1, was determined in human plasma at 1.5, 3, and 7 T, and in human blood at 3 T at 37°C in phantoms ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000577

    authors: Szomolanyi P,Rohrer M,Frenzel T,Noebauer-Huhmann IM,Jost G,Endrikat J,Trattnig S,Pietsch H

    更新日期:2019-09-01 00:00:00

  • Mechanical and biochemical cardiac disturbances induced by bolus administration of iodinated contrast media and noniodinated solutions.

    abstract:RATIONALE AND OBJECTIVES:Bolus injection of iodinated contrast media has been observed to alter myocardial mechanical function, but the consequences on cellular metabolism are poorly documented. Modifications of metabolic parameters (intracellular pH as well as adenosine triphosphate [ATP], phosphocreatine, and inorgan...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199501000-00001

    authors: Goossens A,Vander Elst L,Van Haverbeke Y,Muller RN

    更新日期:1995-01-01 00:00:00

  • Delayed Gadolinium Leakage in Ocular Structures: A Potential Marker for Age- and Vascular Risk Factor-Related Small Vessel Disease?

    abstract:BACKGROUND:Gadolinium leakage in ocular structures (GLOS) was recently observed in fluid-attenuated inversion recovery (FLAIR) images obtained the day after an initial gadolinium injection in stroke patients. The specificity of GLOS to stroke and its mechanisms remain unclear. OBJECTIVE:We investigated the factors ass...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000757

    authors: Galmiche C,Moal B,Marnat G,Sagnier S,Schweitzer C,Dousset V,Sibon I,Tourdias T

    更新日期:2021-01-19 00:00:00

  • Pyrroxamide, a nonionic nitroxyl spin label contrast agent for magnetic resonance imaging. Mutagenesis and cell survival.

    abstract::Pyrroxamide [N-(1-hydroxymethyl-2,3-dihydroxypropyl)-2,2,5,5-tetramethyl pyrrolidine-1-oxyl-3-carboxyamide] is a newly tested nonionic monomeric nitroxyl compound with demonstrated effectiveness for MRI contrast enhancement at doses as low as 10(-3) M. Pyrroxamide and its hydroxylamine metabolic derivative were tested...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198808000-00013

    authors: Gordon DG,Brasch RC,Ogan MD,Deen D

    更新日期:1988-08-01 00:00:00

  • The current status of total joint replacement.

    abstract::The last two decades have witnessed tremendous strides in the evolution of acceptable and successful methods of prosthetic replacement for the arthritic joint. By and large, these techniques are predictable and durable, though not always to the complete satisfaction of the patient and surgeon. Despite the recent empha...

    journal_title:Investigative radiology

    pub_type: 杂志文章,评审

    doi:10.1097/00004424-199001000-00022

    authors: Volz RG,Benjamin JB

    更新日期:1990-01-01 00:00:00

  • Experimental pulmonary arteritis.

    abstract::Experimental pulmonary arteritis was produced in rabbits by intravenous injection of alveolar macrophages from donor rabbits. These animals, along with matched controls, were studied with pulmonary angiography to test the hypothesis that angiography could detect the vasculitic process in life. The animals were then sa...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198007000-00005

    authors: Hicken P,Hogg JC,Pare PD

    更新日期:1980-07-01 00:00:00

  • Selective catheterization for magnification angiography of internal spermatic and proper hepatic arteries in rabbits.

    abstract::A method is presented for selective catheterization and filming of the small internal spermatic and proper hepatic arteries in rabbits. The angiograms thus obtained afford clear delineation of the vessels and their branches and can enhance radiographic investigation of a variety of experimental disease models. ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197705000-00009

    authors: Young S,Hollenberg NK

    更新日期:1977-05-01 00:00:00

  • A Single-Arm, Multicenter Validation Study of Prostate Cancer Localization and Aggressiveness With a Quantitative Multiparametric Magnetic Resonance Imaging Approach.

    abstract:OBJECTIVES:The aims of this study were to assess the discriminative performance of quantitative multiparametric magnetic resonance imaging (mpMRI) between prostate cancer and noncancer tissues and between tumor grade groups (GGs) in a multicenter, single-vendor study, and to investigate to what extent site-specific dif...

    journal_title:Investigative radiology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/RLI.0000000000000558

    authors: Maas MC,Litjens GJS,Wright AJ,Attenberger UI,Haider MA,Helbich TH,Kiefer B,Macura KJ,Margolis DJA,Padhani AR,Selnæs KM,Villeirs GM,Fütterer JJ,Scheenen TWJ

    更新日期:2019-07-01 00:00:00

  • Phlebography. Survey and present state.

    abstract::Milestones in the history of phlebography are shortly reviewed. The present state of phlebography with emphasis upon the role of new nonionic contrast media is presented. ...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Enge I

    更新日期:1985-01-01 00:00:00

  • Ultrasound Time-Harmonic Elastography of the Pancreas: Reference Values and Clinical Feasibility.

    abstract:OBJECTIVES:Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumor with a very low 5-year survival rate of 8%. The aims of this study are to determine reference values and physiologic confounders in healthy pancreas and to assess the diagnostic accuracy of ultrasound time-harmonic elastography (THE) in the d...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000638

    authors: Burkhardt C,Tzschätzsch H,Schmuck R,Bahra M,Jürgensen C,Pelzer U,Hamm B,Braun J,Sack I,Marticorena Garcia SR

    更新日期:2020-05-01 00:00:00

  • Expert learning system network for diagnosis of breast calcifications.

    abstract::Breast calcification diagnosis was studied by using clinical findings and computerized image processing of a mammogram in a network of trained expert learning systems (Outcome Advisor [OA]). The system was tested with records not used for training and performance was compared with radiologist. The network was 72% accu...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199106000-00004

    authors: Patrick EA,Moskowitz M,Mansukhani VT,Gruenstein EI

    更新日期:1991-06-01 00:00:00

  • Evaluation of diffusion-weighted MR imaging at inclusion in an active surveillance protocol for low-risk prostate cancer.

    abstract:PURPOSE:We aimed to determine whether diffusion-weighted magnetic resonance imaging, by means of the apparent diffusion coefficient (ADC), is able to guide magnetic resonance-guided biopsy in patients fit for active surveillance (AS) and identify patients harboring high-grade Gleason components not suitable for AS. MA...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e31827b711e

    authors: Somford DM,Hoeks CM,Hulsbergen-van de Kaa CA,Hambrock T,Fütterer JJ,Witjes JA,Bangma CH,Vergunst H,Smits GA,Oddens JR,van Oort IM,Barentsz JO,MR-PRIAS Collaboration Group.

    更新日期:2013-03-01 00:00:00

  • Contrast gradient and the detection of lung nodules.

    abstract::The effects of edge gradient and blur on the detection pulmonary nodules were studied, using a test series of 175 artificial nodules on 30 chest films. The nodules were of homogeneous texture, about 1 cm in diameter and had a mean contrast of .12. Six observers viewed the film set, scoring both location and confidence...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197901000-00004

    authors: Kundel HL,Revesz G,Toto L

    更新日期:1979-01-01 00:00:00

  • Sclerotherapy of the gallbladder in pigs. Development of a balloon catheter for a single-step procedure.

    abstract::Gallbladder sclerotherapy after permanent cystic duct occlusion, to prevent gallstone recurrence in nonsurgical gallstone therapy, is at least a two-stage procedure. A balloon catheter was developed to perform gallbladder sclerotherapy with only temporary occlusion of the cystic duct, and the efficacy and safety of th...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199109000-00005

    authors: Brakel K,Laméris JS,Vergunst H,Ten Kate FJ,Nijs HG,Terpstra OT

    更新日期:1991-09-01 00:00:00

  • A method for evaluating the bronchial circulation. Preliminary observations.

    abstract::Due to the small size of the bronchial arteries, the bronchial circulation is difficult to study and remains poorly understood. We have utilized single photon emission computed tomography (SPECT) as a noninvasive means of studying the bronchial circulation. Imaging studies were performed in sheep before and after the ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199001000-00014

    authors: Chiles C,Newman GE,Blinder RA

    更新日期:1990-01-01 00:00:00

  • Comparison of left ventricular ejection fraction and regional contractility fraction pre and post coronary angiography.

    abstract::Thirty patients [four normals, eight with mild and 18 with severe coronary artery disease (CAD)] were studied to evaluate left ventricular function type and post coronary angiography. The end diastolic volume (EDV), end systolic volume (ESV), ejection fraction (EF) and the regional contractility fractions (RCF) of eig...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197603000-00009

    authors: Sos TA,Baltaxe HA

    更新日期:1976-03-01 00:00:00

  • 18F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance in Lymphoma: Comparison With 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and With the Addition of Magnetic Resonance Diffusion-Weighted Imaging.

    abstract:OBJECTIVES:The aim of this study was to compare F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/magnetic resonance (MR) (with and without diffusion-weighted imaging [DWI]) to F-FDG PET/computed tomography (CT), with regard to the assessment of nodal and extranodal involvement, in patients with Hodgkin lym...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000218

    authors: Giraudo C,Raderer M,Karanikas G,Weber M,Kiesewetter B,Dolak W,Simonitsch-Klupp I,Mayerhoefer ME

    更新日期:2016-03-01 00:00:00

  • Diminished cerebrospinal fluid beta-endorphin concentration in monkeys with arachnoiditis.

    abstract::Altered concentrations of brain beta endorphin and spinal cord encephalin have been reported in mice with iatrogenic arachnoiditis. We measured beta-endorphin concentration in cerebrospinal fluid (CSF) in normal monkeys and in monkeys with various degrees of arachnoiditis resulting from myelography and spinal surgery ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198803000-00006

    authors: Lipman BT,Haughton VM

    更新日期:1988-03-01 00:00:00