Abstract:
RATIONALE AND OBJECTIVES:The efficacy of gadoteridol for contrast enhancement of central nervous system pathology was assessed in a multicenter clinical trial involving 411 patients suspected of having intracranial or spinal pathology. METHODS:Magnetic resonance imaging was performed before and after intravenous administration of 0.10 mmol/kg gadoteridol. Two groups of images were interpreted by one of two neuroradiologists blinded to patient history. The results were analyzed separately. RESULTS:Patients with radiologic evidence of disease demonstrated enhancement of intracranial pathologic lesions in 44 of 63 (70%) and in 91 of 111 (82%) cases, respectively, whereas enhancement of spinal lesions was observed in 36 of 58 (62%) and in 65 of 78 (83%) cases, respectively. Subjectively, postcontrast scans provided more information than precontrast images in 37 of 63 (59%) and 84 of 111 (76%) intracranial cases, respectively, and in 25 of 58 (43%) and 55 of 78 (71%) spinal cases, respectively. Additional information included the subjective sense that there was improved visualization of pathology and definition of lesion borders. CONCLUSIONS:Subjective assessment of magnetic resonance scans suggest gadoteridol is an effective intravenous contrast agent for magnetic resonance imaging.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Runge VM,Bronen RA,Davis KRkeywords:
subject
Has Abstractpub_date
1992-08-01 00:00:00pages
S22-32eissn
0020-9996issn
1536-0210journal_volume
27 Suppl 1pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract:RATIONALE AND OBJECTIVES:Dynamic contrast enhanced (DCE) MR mammography (MRM) uses tumor capillary density differences for prognosis. The heterogeneous response of permeability-surface area products (PS = Kp<-->t) was examined in mammary tumors, as a function of contrast agent size, to determine what effect ROI size mi...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200204000-00003
更新日期:2002-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To assess whether differences in cerebral atrophy and white matter lesions or in the presence of lactate and lipid signals can explain the observed differences in brain choline, creatine, and N-acetylaspartate levels between healthy elderly women and men. METHODS:In addition to standard magnet...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200110000-00005
更新日期:2001-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors developed a two-dimensional breathhold magnetic resonance (MR) technique for the direct imaging of pulmonary emboli. METHODS:In vitro MR imaging was performed to demonstrate the potential generation of clot-blood contrast by in vivo pulmonary embolism (PE). A two-dimensional magnet...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199708000-00001
更新日期:1997-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The objective of the present study was to compare the data regarding the ability of real-time myocardial contrast echocardiography (MCE) to assess altered myocardial blood flow produced by graded coronary stenoses between open- and closed-chest canine models. MATERIALS AND METHODS:Three grades...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200301000-00006
更新日期:2003-01-01 00:00:00
abstract::Recent experimental data underlies the role of hypoxic tubular injury in the pathophysiology of radiocontrast nephropathy. Although systemic transient hypoxemia, increased blood viscosity, and a leftward shift of the oxygen-hemoglobin dissociation curve may all contribute to intrarenal hypoxia, imbalance between oxyge...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/00004424-199911000-00004
更新日期:1999-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Measurements of segmental contraction of the left ventricle by standard magnetic resonance imaging (MRI) and two-dimensional echocardiography involve the comparison of diastolic and systolic time frames acquired from the same imaging plane in space. As the cone-shaped left ventricle shortens al...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199209000-00004
更新日期:1992-09-01 00:00:00
abstract:OBJECTIVE:This study aims for targeted biopsy validation of magnetic resonance fingerprinting (MRF) and diffusion mapping for characterizing peripheral zone (PZ) prostate cancer and noncancers. MATERIALS AND METHODS:One hundred four PZ lesions in 85 patients who underwent magnetic resonance imaging were retrospectivel...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000569
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:To test the technique and feasibility of translating tumor suspicious region maps in the prostate, obtained by multimodality, anatomic, and functional 3T magnetic resonance imaging (MRI) data to 32-channel coil, T2-weighted (T2-w), 3T MR images, for directing MR-guided biopsies. Furthermore, to evaluate the ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31817d0506
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:We sought to evaluate the influence of tube voltage on the visualization of acute myocardial infarction (MI) in cardiac multislice spiral computed tomography (MSCT). MATERIALS AND METHODS:Acute MI was induced in 12 domestic pigs by a 45-minute balloon occlusion of the left anterior descending artery. Delayed...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000251577.68223.84
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVES:X-ray computed tomography (CT) using phase contrast can provide images with greatly enhanced soft-tissue contrast in comparison to conventional attenuation-based CT. We report on the first scan of a human specimen recorded with a phase-contrast CT system based on an x-ray grating interferometer and a convent...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181e21866
更新日期:2010-07-01 00:00:00
abstract::Experimental pulmonary arteritis was produced in rabbits by intravenous injection of alveolar macrophages from donor rabbits. These animals, along with matched controls, were studied with pulmonary angiography to test the hypothesis that angiography could detect the vasculitic process in life. The animals were then sa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198007000-00005
更新日期:1980-07-01 00:00:00
abstract::Three facets of dual-energy quantitative computed tomography are studied: (1) the algorithm for postprocessing data (the methods of Cann, Laval-Jeantet et al, Goodsitt et al [two methods], and Nickoloff et al); (2) the influence of choice of tissue-equivalent materials for calibration; and (3) the difference between c...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199008000-00003
更新日期:1990-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Very small dextran-coated magnetite particles were developed. These particles can be used either as immunospecific contrast agents for MRI by coupling to antibodies or as an interstitial contrast agent. METHODS:The particles were synthesized from iron chloride/dextran solutions. Size was evalu...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200009000-00006
更新日期:2000-09-01 00:00:00
abstract::An ultrasound phantom was constructed simulating fetal femurs in amniotic fluid. Bones of 26, 36, 50, 58, and 70 mm, representative of gestational ages ranging from 17 to 36 weeks, were scanned with mechanical sector, phased sector, and linear array systems (ATL, Diasonics, Acuson, and GE). Measurements were made with...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198505000-00016
更新日期:1985-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Laser-induced interstitial thermotherapy (LITT) may become an attractive modality for minimally invasive tumor therapy. Magnetic resonance imaging (MRI) could be used to assist this procedure. METHODS:A T1-weighted turbo fast low-angle shot (FLASH) sequence for on-line monitoring of the laser-...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199403000-00015
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVES:Thermal dose in tumor tissue is a key factor for regional hyperthermia (HT) combined with chemotherapy and for drug delivery using thermosensitive liposomes (TSL). It influences therapy outcome, affects the accumulation of liposomes, and triggers the content release from TSL in the target tissue. For the dev...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31818768cd
更新日期:2008-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Hepatocellular carcinomas (HCCs) usually consist of components of different histologic grade. Using surgically resected specimens, the authors obtained high-resolution magnetic resonance (MR) images and studied the relationship between histologic grade of HCCs and MR signal intensity. METHOD:I...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199308000-00007
更新日期:1993-08-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the feasibility of a computed tomography (CT) protocol enabling the visualization of the prostatic artery (PA) before prostatic artery embolization (PAE) in benign prostatic hyperplasia, which provides quantitative perfusion information of the prostate gland. MATERIALS ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000582
更新日期:2019-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To compare technical aspects and neointima formation of a new Nitinol stent and a Wallstent. METHODS:A Nitinol sten and a Wallstent were placed into the iliac arteries of 14 sheep (total of 28 stents) and followed angiographically. Seven sheep were killed after 1 month and 7 after 4.5 months. ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199507000-00004
更新日期:1995-07-01 00:00:00
abstract::Lymphangiograms of canine cardiac and pulmonary efferent mediastinal lymphatics were made by cannulation and injection of Ethiodol. Injections were made singly and serially. The mediastinal lymphatics and lymph nodes, which constitute the pathways of drainage of the heart and lungs, were delineated from the point of c...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197901000-00012
更新日期:1979-01-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31827b711e
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the feasibility of kidney stone composition analysis using spectral detector computed tomography scanner (SDCT) with normal- and low-dose imaging protocols. METHODS:A total of 154 stones harvested from nephrolithotripsy or nephrolithotomy with a known monocrystalline...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000468
更新日期:2018-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To compare electron beam tomography (EBT) with MR imaging (MRI) for detection of restenosis after coronary angioplasty (PTCA). METHODS:One hundred eighteen patients after PTCA were investigated. By EBT, 50 axial images were acquired (3-mm slice thickness, 120-160 mL radiographic contrast agent...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200207000-00005
更新日期:2002-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:The authors performed a retrospective study in ultrasound to investigate new aspects in the sonomorphology of lymph node metastases of the neck. In this study, it could be demonstrated the first time that the histologic characteristics of the metastases determine the sonographic appearance. In a...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199609000-00001
更新日期:1996-09-01 00:00:00
abstract:PURPOSE:Magnetic Resonance Imaging (MRI) has become the method of choice in the evaluation of patients with suspected cervical artery dissection (CAD). However, reliable identification of acute CAD might be impaired by the limited spatial resolution of standard 1.5 T MRI. In this preliminary study, we implemented a mul...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000195836.57778.1f
更新日期:2006-02-01 00:00:00
abstract:PURPOSE:To evaluate the feasibility of ex vivo ablation implementing a cryo-based internally cooled bipolar radiofrequency (RF) applicator and to determine the influence of power and gas pressure on the size and shape of the resulting ablation zones. MATERIALS AND METHODS:Two hundred twenty-five ablations were perform...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181b66d11
更新日期:2009-12-01 00:00:00
abstract::The last two decades have witnessed tremendous strides in the evolution of acceptable and successful methods of prosthetic replacement for the arthritic joint. By and large, these techniques are predictable and durable, though not always to the complete satisfaction of the patient and surgeon. Despite the recent empha...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/00004424-199001000-00022
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to assess whether the recently developed method of grating-based x-ray dark-field radiography can improve the diagnosis of pulmonary emphysema in vivo. MATERIALS AND METHODS:Pulmonary emphysema was induced in female C57BL/6N mice using endotracheal instillation of porcine pancr...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000067
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to assess whether fluorochrome-coupled bacterial magnetic nanoparticles can be used as bimodal contrast agent for both magnetic resonance imaging (MRI) and near-infrared fluorescence optical (NIRF) imaging of cultured macrophages. MATERIALS AND METHODS:Bacterial magnetic nanopa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000255832.44443.e7
更新日期:2007-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Studies describing the effects of radiographic contrast media (RCM) in leukocyte chemotaxis have been contradictory. No studies have been performed after in-vivo exposure. The authors assess the effect of RCM on leukocytes following in-vivo exposure. METHODS:Seventeen patients were studied aft...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199401000-00012
更新日期:1994-01-01 00:00:00