Magnetic resonance imaging-controlled laser-induced interstitial thermotherapy.

Abstract:

RATIONALE AND OBJECTIVES:Laser-induced interstitial thermotherapy (LITT) may become an attractive modality for minimally invasive tumor therapy. Magnetic resonance imaging (MRI) could be used to assist this procedure. METHODS:A T1-weighted turbo fast low-angle shot (FLASH) sequence for on-line monitoring of the laser-influenced region (liver, muscle) was investigated. Sequence parameters were optimized for maximal image contrast. Magnetic resonance imaging-controlled LITT was performed in vitro, in vivo (rabbits), and in 8 human investigations (6 patients). Special laser applicators were used to establish a uniform laser light distribution. RESULTS:With the MRI sequence used, the LITT region is visualized as a bright area outlined by a dark border. This dark border corresponds to an isotherm of 45 +/- 2 degrees C depending on the sequence parameters used. CONCLUSION:With the T1-weighted turbo-FLASH sequence, MRI can be used for on-line monitoring of interstitial laser-induced thermotherapy in moving organs.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Gewiese B,Beuthan J,Fobbe F,Stiller D,Müller G,Böse-Landgraf J,Wolf KJ,Deimling M

doi

10.1097/00004424-199403000-00015

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

345-51

issue

3

eissn

0020-9996

issn

1536-0210

journal_volume

29

pub_type

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