Abstract:
RATIONALE AND OBJECTIVES:The capability of an indirect computed tomographic lymphography (CT-LG) using a nonionic monometric contrast medium iopamidol for visualizing breast lymphatic pathways was preliminarily tested. MATERIALS AND METHODS:In 10 female dogs, a total of 0.5 and 1 mL of undiluted iopamidol was injected subcutaneously into the skin areas overlying the both caudal mammary glands. Contiguous 2-mm-thick multidetector raw helical CT images were obtained through the upper thorax and axilla before and during 60 minutes after gentle massage at the injection sites, with reconstruction into three-dimensional (3D) postcontrast CT images. The first lymph node (1st LN) directly draining from the injection sites was marked under CT guidance, followed by pre- and postmortem examinations. This CT-LG with 2-mL iopamidol was also attempted in five human female volunteers. RESULTS:Even with 0.5-mL iopamidol, the CT-LG clearly visualized the direct connection of the 1st LN and lymphatic vessels draining from the injection sites throughout the examination time in all the animals, with the maximum CT attenuation of 269 Hounsfield units (HU) +/- 137 in the 1st LN on the first postcontrast images. The topographic 3D images provided comprehensive anatomic outlines of these lymphatic pathways. Of the total of 20 opacified 1st LN and 110 distant nodes, all the 1st LN (100%) and 92 (83.6%) distant nodes could be resected at pre- or postmortem, with a good correlation with the CT images. The CT-LG also effectively localized the 1st LN with the maximum attenuation of 223 HU +/- 63 in the human volunteers, without any significant late adverse effects. CONCLUSION:Indirect CT-LG with iopamidol may have excellent potential for visualizing breast lymphatic drainage and for preoperative localization of breast sentinel lymph nodes.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Suga K,Ogasawara N,Yuan Y,Okada M,Matsunaga N,Tangoku Adoi
10.1097/00004424-200302000-00002keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
73-84issue
2eissn
0020-9996issn
1536-0210journal_volume
38pub_type
杂志文章abstract::We examined the acute systemic and renal hemodynamic effects of intravenous meglumine/sodium diatrizoate-76% and iopamidol in euvolemic and dehydrated dogs. The physiologic responses were compared with acute changes in the level of an endogenous heparin-like material (EHM). One of eight dehydrated dogs receiving diatr...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198610000-00005
更新日期:1986-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors evaluate the use of a new device for interventional creation of atrial septal defects (ASD) working with high-frequency alternating current in an in vitro study with porcine atria. METHODS:The device consists of a symmetrical cage of six superelastic monofile wires, including a mic...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199702000-00003
更新日期:1997-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Two independent gold standards and diagnoses from three-dimensional computed tomography (CT) images were used to examine the possibility that craniosynostosis is a binary abnormality that potentially may be diagnosed without error. METHODS:Surgical reports, histology of excised sutures, and th...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199410000-00005
更新日期:1994-10-01 00:00:00
abstract::Proton magnetic resonance (MR) spectroscopy with homonuclear editing was used to assess lactate accumulation in ischemic and anoxic hearts perfused according to the Langendorff method. An increase in the lactate signal was observed after 5 minutes of ischemia and after 10 to 20 minutes of anoxia. This study demonstrat...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198708000-00004
更新日期:1987-08-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess the effects of gadolinium (Gd3+), provided as gadolinium chloride, on fibroblast function. MATERIALS AND METHODS:Human dermal fibroblasts in monolayer culture and intact skin in organ culture were exposed to the lanthanide metal (1-20 μM). RESULTS:Increased proliferat...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181e943d2
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVES:X-ray computed tomography (CT) using phase contrast can provide images with greatly enhanced soft-tissue contrast in comparison to conventional attenuation-based CT. We report on the first scan of a human specimen recorded with a phase-contrast CT system based on an x-ray grating interferometer and a convent...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181e21866
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVES:Magnetic resonance imaging guidance has been sporadically reported for renal tumor cryoablation (CA); therefore, clinical experience with this modality is still limited.The aim of this study is to retrospectively analyze our 10-year experience with renal tumor CA performed on a 1.5 T magnetic resonance imagi...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000719
更新日期:2020-09-04 00:00:00
abstract::The authors compared the renal toxicity of the low osmolality radiocontrast agents, iohexol and ioxaglate, and the ionic agent, iothalamate, at equivalent iodine dose, using experimental models in vitro and in vivo. In isolated perfused rat kidneys, all agents induced comparable biphasic hemodynamic changes, associate...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199104000-00008
更新日期:1991-04-01 00:00:00
abstract:OBJECTIVE:To investigate three-echo T2*-corrected Dixon magnetic resonance imaging (MRI) for noninvasively estimating hepatic fat content (HFC) compared with biopsy. MATERIALS AND METHODS:One hundred patients (50 men, 50 women; mean age, 57.7±14.2 years) underwent clinically indicated liver core biopsy (102 valid tiss...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31822b124c
更新日期:2011-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:A new hepatobiliary gadolinium chelate, gadolinium (Gd) 2,5-BPA-DO3A, was compared in two animal species with Gd HP-DO3A (gadoteridol), a clinically approved extracellular contrast agent, and Gd Cy2-DOTA, a second hepatobiliary chelate in preclinical development. The ligand in Gd 2,5-BPA-DO3A i...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199601000-00003
更新日期:1996-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To compare the visibility and localization of extratemporal cortical lesions in extratemporal epilepsy by using curved reconstruction (CR) and three-dimensional surface rendering (3D SR) of 3D-acquired MR images and to study the degree of confidence with which localizations are made, particular...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200104000-00005
更新日期:2001-04-01 00:00:00
abstract:PURPOSE:We sought to evaluate the potential of dynamic contrast enhancement after the intravenous administration of an iodine-based contrast medium in full-field digital mammography. MATERIAL AND METHODS:A protocol for image acquisition was established for contrast-enhanced mammography and the mammography unit (Senogr...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000167421.83203.4e
更新日期:2005-07-01 00:00:00
abstract:UNLABELLED:Szapiro D, Ghaye B, Willems V, et al. Evaluation of CT time-density curves of lower-limb veins. Invest Radiol 2001;36:164-169. RATIONALE AND OBJECTIVES:To evaluate time-density curves of the lower-limb veins for optimization of CT venography. METHODS:Fifty patients referred for chest CT were randomized int...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004424-200103000-00005
更新日期:2001-03-01 00:00:00
abstract::A high-speed computed tomography (CT) scanner was used for measuring flow in a phantom and in the common carotid arteries of six dogs. The general ability of the scanner to assess flow using contrast media boluses was tested with the phantom. The validated simple concept was then used in the animals. The carotid blood...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198712000-00008
更新日期:1987-12-01 00:00:00
abstract::The large intestines of eight boxer dogs with canine histiocytic ulcerative colitis (CHUC) and 10 normal dogs were studied by in vivo angiography and postmortem microangiography. The vascular abnormalities were correlated with the gross and histologic pathology found at necropsy. The angiographic abnormalities were ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197505000-00005
更新日期:1975-05-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/magnetic resonance (MR) (with and without diffusion-weighted imaging [DWI]) to F-FDG PET/computed tomography (CT), with regard to the assessment of nodal and extranodal involvement, in patients with Hodgkin lym...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000218
更新日期:2016-03-01 00:00:00
abstract::Groups of 5 fasting male and female patients aged 32-83 years were each given 3 gm of the cholecystographic contrast medium iosumetic acid in micronized form (particle size less than 20 mum); Group I with 150 ml tea (standard administration); Group II with 500 ml tea; Group III with 150 ml tea plus 10 mg metocloprami...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197607000-00009
更新日期:1976-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare changes in the signal intensity (SI) ratio of the dentate nucleus (DN) to the pons, DN to cerebrospinal fluid (CSF), and globus pallidus (GP) to thalamus on unenhanced T1-weighted magnetic resonance imaging (MRI) scans after serial injections of the macrocyclic gadolinium-...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000227
更新日期:2015-12-01 00:00:00
abstract::Three methods are presented which provide statistically acceptable estimates of mean transit time of opacified blood during angiography. While the methods vary in precision, the selection of the method appropriate for any particular experimental model depends on the degree of precision required to demonstrate the effe...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197707000-00004
更新日期:1977-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate different vein graft-coated stent systems in the endovascular treatment of experimental arteriovenous fistulae (AVF) in a canine model. METHODS:Bilateral carotid-to-external jugular vein AVF were created. Two balloon-expandable tantalum stents (Strecker stent), two self-expanding n...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199901000-00004
更新日期:1999-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors investigated whether the ability of human malignant melanoma cells to increase in cell number or their ability to remain viable was compromised by high-field strength static magnetic fields. Normal human fibroblasts also were studied to determine if any magnetic field-related altera...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199210000-00014
更新日期:1992-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The efficacy of gadoteridol for contrast enhancement of central nervous system pathology was assessed in a multicenter clinical trial involving 411 patients suspected of having intracranial or spinal pathology. METHODS:Magnetic resonance imaging was performed before and after intravenous admin...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1992-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The reflux of ethanol into the peritoneal cavity during percutaneous ethanol injection therapy (PEIT) of liver neoplasms may cause pain and other side effects. This article studies the optimal injection technique to minimize the reflux of ethanol. METHODS:A technique using normal postmortem pi...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199211000-00008
更新日期:1992-11-01 00:00:00
abstract::The ideal contrast agent in patients suspected of having gastrointestinal perforation is an iso-osmolar, or nearly iso-osmolar substance, that causes no peritoneal reaction. Iopamidol is a nonionic water-soluble contrast medium that may be considered in such situations. Intraperitoneal injections of ionic and nonionic...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199002000-00008
更新日期:1990-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors used gadolinium (Gd) chelate as a T1, T2, and T2* enhancing agent in reperfused myocardial infarction to compare the appearance of reperfused myocardial infarction on spin echo and gradient echo magnetic resonance (MR) sequences. METHODS:Rats (n = 28) were subjected to reperfused m...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199807000-00002
更新日期:1998-07-01 00:00:00
abstract::Radiation dose in computed tomography (CT) has become a hot topic due to an upward trend in the number of CT procedures worldwide and the relatively high doses associated with these procedures. The main aim of this review article is to provide an overview of the most frequently used metrics for CT radiation dose chara...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000727
更新日期:2021-01-01 00:00:00
abstract::We have examined the effect of dose on contrast medium-induced reductions in glomerular filtration in anesthetized rabbits. The fraction of renal plasma flow that is filtered, the filtration fraction, was directly measured by the renal arteriovenous difference method using technetium-99m (99mTc) (Sn) DTPA as the trace...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198309000-00007
更新日期:1983-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To compare trabecular bone structure measures obtained in magnetic resonance images of the distal radius and the calcaneus as well as computed tomographic images of the spine versus bone mineral density (BMD) of the spine and the calcaneus in the prediction of osteoporotic spine fracture status...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000129154.50654.4e
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of nephrogenic systemic fibrosis (NSF) in patients with chronic kidney disease (CKD) who have received gadopentetate dimeglumine. MATERIALS AND METHODS:We retrospectively studied all patients who underwent contrast-enhanced magnetic resonance imagings (CE-MRIs) between January 1, ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31819343ba
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the effect of structured reports (SRs) in comparison to nonstructured, free-text (FT) rectal magnetic resonance imaging (MRI) reports in patients with histologically proven rectal cancer and potential effects of both types of reporting on referring surgeons' satisfaction...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000336
更新日期:2017-04-01 00:00:00