Binary nature and radiographic identifiability of craniosynostosis.

Abstract:

RATIONALE AND OBJECTIVES:Two independent gold standards and diagnoses from three-dimensional computed tomography (CT) images were used to examine the possibility that craniosynostosis is a binary abnormality that potentially may be diagnosed without error. METHODS:Surgical reports, histology of excised sutures, and three-dimensional CT images were compared for 25 children undergoing surgical management of craniosynostosis. Surgical reports identified sutures as normal or abnormal. Histology reported suture closure on a 5-point scale. Four radiologists used three-dimensional CT images to diagnose sutures on a 6-point rated response scale. RESULTS:Sutures with histology 0, 1, or 2 were normal on surgical reports, and those with histology 3 or 4 were abnormal. Most readers achieved nearly perfect sensitivity and specificity. Reader confidence was unrelated to degree of pathology. CONCLUSION:Craniosynostosis appears to be binary in our sample. Surgical reports, pathology results, and three-dimensional CT images read by experienced viewers achieved nearly perfect agreement.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Pilgram TK,Vannier MW,Marsh JL,Kraemer BB,Rayne SC,Gado MH,Moran CJ,McAlister WH,Shackelford GD,Hardesty RA

doi

10.1097/00004424-199410000-00005

subject

Has Abstract

pub_date

1994-10-01 00:00:00

pages

890-6

issue

10

eissn

0020-9996

issn

1536-0210

journal_volume

29

pub_type

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