Right-Angled Traction Bronchiectasis in Differentiating Idiopathic Pulmonary Fibrosis Without Honeycombing From Idiopathic Nonspecific Interstitial Pneumonia.


OBJECTIVES:The aim of this study was to conduct a radiopathologic evaluation of right-angled traction bronchiectasis to differentiate idiopathic pulmonary fibrosis (IPF) without honeycombing from idiopathic nonspecific interstitial pneumonia (NSIP). MATERIALS AND METHODS:The derivation cohort included 78 consecutive patients with idiopathic NSIP (n = 39) or IPF (n = 39) without honeycombing who underwent preoperative thin-section computed tomography scans at a single tertiary hospital. The validation cohort comprised 22 patients (14 IPF and 8 NSIP) from another institution. We assessed conventional computed tomography findings, right-angled traction bronchiectasis on minimum intensity projection (MinIP) images, and pathologic features associated with right-angled bronchiectasis. Right-angled traction bronchiectasis was defined as abrupt kinking of a single bronchus by over 90 degrees or an abrupt angle close to 180 degrees of branching bronchi in the background of fibrosis. In the validation cohort, we evaluated the proportion of correct IPF diagnoses and interobserver agreement of 4 radiologists before and after reviewing MinIP images. RESULTS:A probable usual interstitial pneumonia (UIP) pattern (odds ratio [OR], 6.948; 95% confidence interval [CI], 1.525-31.654; P = 0.012) and right-angled traction bronchiectasis (OR, 6.004; 95% CI, 1.980-18.209; P = 0.002) were independently associated with IPF. Patients with right-angled traction bronchiectasis were more likely to have extensive reticular opacity (OR, 1.149; 95% CI, 1.077-1.225; P < 0.001) and pathologically were more likely to have a broad extent of subpleural fibrosis (OR, 4.000; 95% CI, 1.457-10.987; P = 0.007) and relatively thick fibrosis (OR, 7.750; 95% CI, 2.504-23.991; P < 0.001). After reviewing MinIP images, the proportion of correct diagnoses increased from 40.9% to 54.5% to 50.0% to 77.3%. The mean kappa value for right-angled traction bronchiectasis was 0.489 ± 0.192. CONCLUSIONS:Right-angled traction bronchiectasis pathologically reflected a subpleural predominance of fibrosis and partly supported the radiologic differentiation of IPF without honeycombing from idiopathic NSIP.


Invest Radiol


Investigative radiology


Kim H,Yoon SH,Lee HJ,Song SG,Koh J,Jeon YK,Chae KJ,Jin GY,Jin KN,Lee KY,Goo JM




Has Abstract


2020-06-01 00:00:00












  • Interleaved Mapping of Temperature and Longitudinal Relaxation Rate to Monitor Drug Delivery During Magnetic Resonance-Guided High-Intensity Focused Ultrasound-Induced Hyperthermia.

    abstract:OBJECTIVES:Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) is a method to heat lesions noninvasively to a stable, elevated temperature and a well-suited method to induce local hyperthermia (41°C-43°C) in deep-seated tissues. Magnetic Resonance (MR) imaging provides therapy planning on anatomical i...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Kneepkens E,Heijman E,Keupp J,Weiss S,Nicolay K,Grüll H

    更新日期:2017-10-01 00:00:00

  • Pulmonary microangiography. A comparison of in vitro versus in vivo perfusion techniques in dogs.

    abstract::Because of a need to correlate pulmonary microvascular changes with physiologic data during lung injury, in vitro and in vivo pulmonary capillary microangiography was performed on normal dogs and those subjected to oleic acid injury and glass bead microembolization. During these studies, no significant differences wer...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Clark RL,Friedman M,Kwock L,Zaremba J

    更新日期:1983-01-01 00:00:00

  • Sequential change of MR signal intensity of the brain after manganese administration in rabbits. Correlation with manganese concentration and histopathologic findings.

    abstract:RATIONALE AND OBJECTIVES:High signal intensity in the basal ganglia on T1-weighted MR imaging has been reported in chronic manganese (Mn) poisoning. However, the exact meaning of the high signal intensity remains unclear: does it result from Mn itself, secondary pathologic changes of the brain tissue, or both? The goal...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Kim SH,Chang KH,Chi JG,Cheong HK,Kim JY,Kim YM,Han MH

    更新日期:1999-06-01 00:00:00

  • Evaluation of normal prostate tissue, chronic prostatitis, and prostate cancer by quantitative perfusion analysis using a dynamic contrast-enhanced inversion-prepared dual-contrast gradient echo sequence.

    abstract:OBJECTIVE:To quantify independent pharmacokinetic parameters for differentiation of prostate pathology. MATERIAL AND METHODS:Twenty-seven patients with biopsy-proven prostate cancer (PSA: 1.4-16.1 ng/mL) underwent magnetic resonance imaging with a new dynamic contrast-enhanced, inversion-prepared dual-contrast gradien...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Franiel T,Lüdemann L,Rudolph B,Rehbein H,Staack A,Taupitz M,Prochnow D,Beyersdorff D

    更新日期:2008-07-01 00:00:00

  • High-resolution magnetic resonance imaging at 2 Tesla: potential for atherosclerotic lesions exploration in the apolipoprotein E knockout mouse.

    abstract:INTRODUCTION:The aim of the present study was to evaluate the potential of high-resolution MRI at 2 Tesla (T) for direct noninvasive imaging of the aortic wall in a mouse model of atherosclerosis. MATERIAL AND METHODS:A specific mouse antenna was developed and sequence parameters were adjusted. T(1)- and T2-weighted i...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Chaabane L,Soulas EC,Contard F,Salah A,Guerrier D,Briguet A,Douek P

    更新日期:2003-08-01 00:00:00

  • Towards computer analysis of pulmonary infiltration.

    abstract::A feasibility study is described to provide quantitative texture measures to distinguish between normal lung, alveolar infiltrates and interstitial infiltrates. Advanced computer imaging technology and decision making processes were applied to distinguish between these textural patterns. The results, based on computer...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Tully RJ,Conners RW,Harlow CA,Lodwick GS

    更新日期:1978-07-01 00:00:00

  • A large animal model (swine) to study the diagnosis and treatment of cholelithiasis.

    abstract::Human gallstones were surgically placed into the gallbladders of 200 swine. Eight of these swine were used as a prospective series to verify that the placement and presence of human gallstones in their gallbladders caused no significant pathologic changes in the gallbladder and that the gallstones were not spontaneous...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Griffith SL,Burney BT,Fry FJ,Franklin TD Jr

    更新日期:1989-02-01 00:00:00

  • Application of a Novel Iterative Denoising and Image Enhancement Technique in T1-Weighted Precontrast and Postcontrast Gradient Echo Imaging of the Abdomen: Improvement of Image Quality and Diagnostic Confidence.

    abstract:OBJECTIVES:The aim of this study was to investigate the impact of a novel iterative denoising and image enhancement technique in T1-weighted precontrast and postcontrast volume-interpolated breath-hold examination (VIBE) of the abdomen on image quality, noise levels, and diagnostic confidence without change of acquisit...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Gassenmaier S,Afat S,Nickel D,Kannengiesser S,Herrmann J,Hoffmann R,Othman AE

    更新日期:2020-11-18 00:00:00

  • A silicone gel phantom suitable for multimodality imaging.

    abstract::A silicone gel phantom material is described. It can be molded into any shape and it can contain internal cavities. The material is selfsealing allowing the cavities to be filled with liquids. A simple geometric phantom consisting of a rectangular solid with a single internal spherical cavity was fabricated and imaged...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Goldstein DC,Kundel HL,Daube-Witherspoon ME,Thibault LE,Goldstein EJ

    更新日期:1987-02-01 00:00:00

  • Importance of parametric mapping and deconvolution in analyzing magnetic resonance myocardial perfusion images.

    abstract:AIM:: We sought to improve the clinical interpretation of first-pass myocardial magnetic resonance perfusion. Parametric analyses of the myocardial distribution of the contrast agent have been proposed. The objective of the present study was to compare the effectiveness of visual analysis and of a parametric approach i...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Carme S,Maï W,Mazzadi A,Janier M,Revel D,Magnin I,Wiart M,Neyran B,Canet-Soulas E

    更新日期:2006-04-01 00:00:00

  • Estimating digital information throughput rates for radiology networks. A model.

    abstract::The design and implementation of a digital radiology image management system requires the definition, evaluation, and comparison of appropriate measures of system performance. The mean throughput rate is an important measure of the actual performance of a finished system. The mean throughput rate identifies the transm...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Cox GG,Templeton AW,Anderson WH,Cook LT,Hensley KS,Dwyer SJ 3rd

    更新日期:1986-02-01 00:00:00

  • Lactate accumulation in ischemic- and anoxic-isolated rat hearts assessed by H-1 spectroscopy.

    abstract::Proton magnetic resonance (MR) spectroscopy with homonuclear editing was used to assess lactate accumulation in ischemic and anoxic hearts perfused according to the Langendorff method. An increase in the lactate signal was observed after 5 minutes of ischemia and after 10 to 20 minutes of anoxia. This study demonstrat...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Richards TL,Terrier F,Sievers RE,Lipton MJ,Moseley ME,Higgins CB

    更新日期:1987-08-01 00:00:00

  • Consistency of rotator-cuff calcifications. Observations on plain radiography, sonography, computed tomography, and at needle treatment.

    abstract:RATIONALE AND OBJECTIVES:The author analyzes findings of consistency of rotator-cuff calcifications found at ultrasound (US)-guided needle treatment compared with findings of plain radiography, US, and computed tomography (CT). METHODS:Twenty patients had rotator-cuff calcifications (mean diameter, 1.5 cm; range, 1.1-...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Farin PU

    更新日期:1996-05-01 00:00:00

  • Characteristics of magnetic resonance sequences used for imaging silicone gel, saline, and gel-saline implants at low field strengths.

    abstract:RATIONALE AND OBJECTIVES:Low-field magnetic resonance imaging (MRI) evaluation of breast implants is described, with emphasis on the capabilities provided by different imaging sequences. METHODS:Open architecture MR images using a .064-T permanent magnet and three-dimensional Fourier transform and inversion recovery s...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Frankel S,Occhipinti K,Kaufman L,Kramer D,Carlson J,Mineyev M,Friedenthal R

    更新日期:1994-08-01 00:00:00

  • Quantification of Aortic Stiffness by Ultrasound Time-Harmonic Elastography: The Effect of Intravascular Pressure on Elasticity Measures in a Porcine Model.

    abstract:OBJECTIVES:The aim of this study was to investigate blood pressure dependency of ultrasound time-harmonic elastography (THE) for quantification of aortic stiffness. MATERIALS AND METHODS:Thoracoabdominal aortas were surgically removed from 9 healthy domestic pigs and prepared for elastographic experiments. All vessels...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Schaafs LA,Tzschätzsch H,Steffen IG,Braun J,Hamm B,Sack I,Elgeti T

    更新日期:2020-03-01 00:00:00

  • Effect of transcatheter hepatic arterial embolization on angiogenesis in an animal model.

    abstract:OBJECTIVES:Transcatheter arterial embolization (TAE) is used for the treatment of patients with malignant liver tumors. However, the proangiogenesis effect of TAE-associated hypoxia has not been adequately studied. The goal of this study was to determine angiogenic activity in tumors subjected to TAE by evaluating the ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Gupta S,Kobayashi S,Phongkitkarun S,Broemeling LD,Kan Z

    更新日期:2006-06-01 00:00:00

  • Comparison of open- and closed-chest canine model for quantification of coronary stenosis severity by myocardial contrast echocardiography.

    abstract:RATIONALE AND OBJECTIVES:The objective of the present study was to compare the data regarding the ability of real-time myocardial contrast echocardiography (MCE) to assess altered myocardial blood flow produced by graded coronary stenoses between open- and closed-chest canine models. MATERIALS AND METHODS:Three grades...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Masugata H,Peters B,Lafitte S,Yao B,Strachan M,Ling Kwan O,Ohmori K,Mizushige K,Kohno M

    更新日期:2003-01-01 00:00:00

  • Applications of voxel shifting in magnetic resonance imaging.

    abstract::Due to the nature of three-dimensional Fourier transform (3-DFT) data acquisition in magnetic resonance imaging (MRI), the spatial relation between a resolved volume element (a voxel) and the object can be manipulated easily. Those manipulations have practical consequences in terms of registering slice positions with ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Kramer D,Li A,Simovsky I,Hawryszko C,Hale J,Kaufman L

    更新日期:1990-12-01 00:00:00

  • The blood-brain barrier: effects of nonionic contrast media with and without addition of Ca2+ and Mg2+.

    abstract::Trypan blue and 197HgCl2 were used as markers of the increased leakage through the blood-brain barrier which developed after selective injection of different contrast media formulations into the internal carotid arteries of rabbits. Interest was focused on a new, experimental, nonionic medium (C-29) and possible effec...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Golman K

    更新日期:1979-07-01 00:00:00

  • Observer variation in detecting the radiologic features associated with bronchiolitis.

    abstract::Chest radiographs are commonly obtained to assess children for bronchiolitis, both to corroborate the diagnosis and to exclude other diagnostic possibilities. Their utility in this setting has not previously been examined. Using a blinded, randomized study design, we examined the interobserver and intraobserver variat...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Coblentz CL,Babcook CJ,Alton D,Riley BJ,Norman G

    更新日期:1991-02-01 00:00:00

  • Effect of inspiratory and expiratory breathhold on pulmonary perfusion: assessment by pulmonary perfusion magnetic resonance imaging.

    abstract:RATIONALE AND OBJECTIVES:The effect of breathholding on pulmonary perfusion remains largely unknown. The aim of this study was to assess the effect of inspiratory and expiratory breathhold on pulmonary perfusion using quantitative pulmonary perfusion magnetic resonance imaging (MRI). METHODS AND RESULTS:Nine healthy v...

    journal_title:Investigative radiology

    pub_type: 杂志文章


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    更新日期:2005-02-01 00:00:00

  • Effect of additional cations on the twitching reaction to intracarotid, nonionic contrast media in rabbits.

    abstract::Previous investigations in this laboratory have confirmed the observation of facial muscle twitching during intracarotid injections of nonionic contrast media (CM) in rabbits. The reaction appears to be a locally mediated effect. To further investigate this reaction, cortical electroencephalogram (EEG) and facial elec...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Whisson CC,Evill CA,Sage MR,Wilson AJ

    更新日期:1990-09-01 00:00:00

  • Contrast gradient and the detection of lung nodules.

    abstract::The effects of edge gradient and blur on the detection pulmonary nodules were studied, using a test series of 175 artificial nodules on 30 chest films. The nodules were of homogeneous texture, about 1 cm in diameter and had a mean contrast of .12. Six observers viewed the film set, scoring both location and confidence...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Kundel HL,Revesz G,Toto L

    更新日期:1979-01-01 00:00:00

  • Contrast-enhanced magnetic resonance angiography of the renal arteries. Original investigation.

    abstract:RATIONALE AND OBJECTIVES:The authors determine the value of contrast-enhanced, three-dimensional (3D) magnetic resonance angiography (MRA) in the assessment of the renal arteries in comparison with conventional arteriography (CA). METHODS:One hundred three patients (71 m, 32 f) were evaluated with both CA and 3D MRA. ...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Hany TF,Leung DA,Pfammatter T,Debatin JF

    更新日期:1998-09-01 00:00:00

  • Evaluation and validation of ureteric jet index by glomerular filtration rate.

    abstract:RATIONALE AND OBJECTIVES:Ureteric jet index (UJI), a newly developed technique derived from color Doppler ultrasonography, may hold promise in evaluating renal function because of its ability to evaluate individual renal function and the use of nonionizing radiation. To assess the usefulness of UJI, the authors in this...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Chiu NT,Wu CC,Yao WJ,Tu DG,Lee BF,Tong YC,Pan CC

    更新日期:1999-08-01 00:00:00

  • 3 T contrast-enhanced magnetic resonance angiography for evaluation of the intracranial arteries: comparison with time-of-flight magnetic resonance angiography and multislice computed tomography angiography.

    abstract:PURPOSE:We sought to prospectively evaluate the image quality and visualization of the intracranial arteries using high spatial resolution contrast-enhanced magnetic resonance angiography (CE-MRA) at 3 T and to perform intraindividual comparison with time-of-flight (TOF) MRA and multislice CT angiography (CTA). MATERI...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章


    authors: Villablanca JP,Nael K,Habibi R,Nael A,Laub G,Finn JP

    更新日期:2006-11-01 00:00:00

  • Effect of multiple intravenous injections of diatrizoate on iodine concentrations and osmolality. An experimental study in rabbits.

    abstract::Multiple intravenous injections of contrast media are used in radiology, but information regarding corresponding changes in the serum iodine concentrations and osmolality is lacking. We measured the changes in serum iodine concentration and serum osmolality in rabbits after a series of intravenous injections of contra...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Rubin DI,Kido DK,Morris TW,Fischer HW

    更新日期:1987-03-01 00:00:00

  • Biliary tract depiction in living potential liver donors at 3.0-T magnetic resonance cholangiography.

    abstract:OBJECTIVES:To prospectively evaluate accuracy of biliary anatomy depiction and quality of biliary tract visualization of magnetic resonance cholangiography (MRC) at 3.0 T in living potential liver donors (LPLDs). MATERIALS AND METHODS:Our institutional review board approved this study and did not require patient's inf...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Kim SY,Byun JH,Hong HS,Choi EK,Lee SS,Park SH,Lee MG

    更新日期:2008-08-01 00:00:00

  • Trabecular bone structure of the distal radius, the calcaneus, and the spine: which site predicts fracture status of the spine best?

    abstract:RATIONALE AND OBJECTIVES:To compare trabecular bone structure measures obtained in magnetic resonance images of the distal radius and the calcaneus as well as computed tomographic images of the spine versus bone mineral density (BMD) of the spine and the calcaneus in the prediction of osteoporotic spine fracture status...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Link TM,Bauer J,Kollstedt A,Stumpf I,Hudelmaier M,Settles M,Majumdar S,Lochmüller EM,Eckstein F

    更新日期:2004-08-01 00:00:00

  • Influence of soft tissue (fat and fat-free mass) on ultrasound bone velocity: an in vivo study.

    abstract:RATIONALE AND OBJECTIVES:The authors determine the relative effect of soft-tissue compartments, body fat (percent [%Bfat] and weight [Bfat kg]) and fat-free mass (FFM kg), on measurements of ultrasound bone velocity (UBV m/second). METHODS:The authors measured UBV in proximal phalanxes and body fat and fat-free mass b...

    journal_title:Investigative radiology

    pub_type: 杂志文章


    authors: Gómez M,Aguado F,Manuel J,Menéndez JM,Revilla M,Villa LF,Cortés J,Rico H

    更新日期:1997-10-01 00:00:00