Hepatocellular carcinoma: correlation between vascular endothelial growth factor level and degree of enhancement by multiphase contrast-enhanced computed tomography.

Abstract:

RATIONALE AND OBJECTIVES:To determine whether vascular endothelial growth factor (VEGF) is a histopathological factor influencing contrast enhancement of hepatocellular carcinoma (HCC) on computed tomography (CT). METHODS:Twenty-two nodular HCCs underwent multiphase helical CT and surgery. Tumor size, histological grading of differentiation, and type of hepatitis were evaluated. Tumor attenuation was graded as hyperattenuated, isoattenuated, and hypoattenuated. Immunohistochemical staining with anti-VEGF antibody was performed and scored as weak, intermediate, or strong. Spearman's rank correlation test was used. RESULTS:Tumors ranged from 1.0 to 12.0 cm (mean 5.1 cm). The degree of enhancement during the hepatic arterial phase was significantly correlated with VEGF expression. Size was negatively correlated with VEGF expression and the degree of enhancement, but histological grade and type of hepatitis were not correlated with VEGF expression, tumor size, or degree of enhancement. CONCLUSIONS:In HCC, VEGF expression is correlated with the degree of contrast enhancement during arterial-phase CT.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Kwak BK,Shim HJ,Park ES,Kim SA,Choi D,Lim HK,Park CK,Chung JW,Park JH

doi

10.1097/00004424-200108000-00008

keywords:

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

487-92

issue

8

eissn

0020-9996

issn

1536-0210

journal_volume

36

pub_type

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